The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders.

Cell genomics
Authors
Keywords
Abstract

Phenotypic associations have been reported between blood cell traits (BCTs) and a range of neurological and psychiatric disorders (NPDs), but in most cases, it remains unclear whether these associations have a genetic basis and, if so, to what extent genetic correlations reflect causality. Here, we report genetic correlations and Mendelian randomization analyses between 11 NPDs and 29 BCTs, using genome-wide association study summary statistics. We found significant genetic correlations for four BCT-NPD pairs, all of which have prior evidence for a phenotypic correlation. We identified a previously unreported causal effect of increased platelet distribution width on susceptibility to Parkinson's disease. We identified multiple functional genes and regulatory elements for specific BCT-NPD pairs, some of which are targets of known drugs. These results enrich our understanding of the shared genetic landscape underlying BCTs and NPDs and provide a robust foundation for future work to improve prognosis and treatment of common NPDs.

Year of Publication
2023
Journal
Cell genomics
Volume
3
Issue
2
Pages
100249
Date Published
02/2023
ISSN
2666-979X
DOI
10.1016/j.xgen.2022.100249
PubMed ID
36819664
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