The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders.
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Abstract | Phenotypic associations have been reported between blood cell traits (BCTs) and a range of neurological and psychiatric disorders (NPDs), but in most cases, it remains unclear whether these associations have a genetic basis and, if so, to what extent genetic correlations reflect causality. Here, we report genetic correlations and Mendelian randomization analyses between 11 NPDs and 29 BCTs, using genome-wide association study summary statistics. We found significant genetic correlations for four BCT-NPD pairs, all of which have prior evidence for a phenotypic correlation. We identified a previously unreported causal effect of increased platelet distribution width on susceptibility to Parkinson's disease. We identified multiple functional genes and regulatory elements for specific BCT-NPD pairs, some of which are targets of known drugs. These results enrich our understanding of the shared genetic landscape underlying BCTs and NPDs and provide a robust foundation for future work to improve prognosis and treatment of common NPDs. |
Year of Publication | 2023
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Journal | Cell genomics
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Volume | 3
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Issue | 2
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Pages | 100249
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Date Published | 02/2023
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ISSN | 2666-979X
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DOI | 10.1016/j.xgen.2022.100249
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PubMed ID | 36819664
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