Getting Past HSC Security: Cyclosporine H Gives Lentiviruses an Entry Pass.
Cell Stem Cell
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Abstract | In this issue of Cell Stem Cell, Petrillo et al. (2018) improve lentiviral transduction of hematopoietic stem cells (HSCs) by using cyclosporine H to relieve viral entry restriction by interferon-induced transmembrane protein 3 (IFITM3). This finding promises to enhance the efficiency of ex vivo therapeutic gene transfer and gene editing of HSCs. |
Year of Publication | 2018
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Journal | Cell Stem Cell
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Volume | 23
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Issue | 6
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Pages | 775-776
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Date Published | 2018 Dec 06
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ISSN | 1875-9777
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DOI | 10.1016/j.stem.2018.11.008
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PubMed ID | 30526877
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