Getting Past HSC Security: Cyclosporine H Gives Lentiviruses an Entry Pass.

Cell Stem Cell
Authors
Keywords
Abstract

In this issue of Cell Stem Cell, Petrillo et al. (2018) improve lentiviral transduction of hematopoietic stem cells (HSCs) by using cyclosporine H to relieve viral entry restriction by interferon-induced transmembrane protein 3 (IFITM3). This finding promises to enhance the efficiency of ex vivo therapeutic gene transfer and gene editing of HSCs.

Year of Publication
2018
Journal
Cell Stem Cell
Volume
23
Issue
6
Pages
775-776
Date Published
2018 Dec 06
ISSN
1875-9777
DOI
10.1016/j.stem.2018.11.008
PubMed ID
30526877
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