The plasticity of dendritic cell responses to pathogens and their components.

Science
Authors
Keywords
Abstract

Dendritic cells are involved in the initiation of both innate and adaptive immunity. To systematically explore how dendritic cells modulate the immune system in response to different pathogens, we used oligonucleotide microarrays to measure gene expression profiles of dendritic cells in response to Escherichia coli, Candida albicans, and influenza virus as well as to their molecular components. Both a shared core response and pathogen-specific programs of gene expression were observed upon exposure to each of these pathogens. These results reveal that dendritic cells sense diverse pathogens and elicit tailored pathogen-specific immune responses.

Year of Publication
2001
Journal
Science
Volume
294
Issue
5543
Pages
870-5
Date Published
2001 Oct 26
ISSN
0036-8075
DOI
10.1126/science.294.5543.870
PubMed ID
11679675
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