Genetic linkage map of human chromosome 7 with 63 DNA markers.

Proc Natl Acad Sci U S A

Authors	Barker P Green R Knowlton J Schumm E Lander A Oliphant H Willard G Akots V Brown T Gravius
Keywords	Humans Genetic Markers Chromosome Mapping Polymorphism, Genetic Genetic Linkage Chromosomes, Human, Pair 7 Polymorphism, Restriction Fragment Length DNA, Recombinant
Abstract	High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have constructed a genetic map of chromosome 7 with 63 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed multilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.
Year of Publication	1987
Journal	Proc Natl Acad Sci U S A
Volume	84
Issue	22
Pages	8006-10
Date Published	1987 Nov
ISSN	0027-8424
PubMed ID	2891136
PubMed Central ID	PMC299465
Links	PubMed Google Scholar
Grant list	AM37656-01 / AM / NIADDK NIH HHS / United States