Construction of multilocus genetic linkage maps in humans.
Proc Natl Acad Sci U S A
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Abstract | Human genetic linkage maps are most accurately constructed by using information from many loci simultaneously. Traditional methods for such multilocus linkage analysis are computationally prohibitive in general, even with supercomputers. The problem has acquired practical importance because of the current international collaboration aimed at constructing a complete human linkage map of DNA markers through the study of three-generation pedigrees. We describe here several alternative algorithms for constructing human linkage maps given a specified gene order. One method allows maximum-likelihood multilocus linkage maps for dozens of DNA markers in such three-generation pedigrees to be constructed in minutes. |
Year of Publication | 1987
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Journal | Proc Natl Acad Sci U S A
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Volume | 84
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Issue | 8
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Pages | 2363-7
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Date Published | 1987 Apr
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ISSN | 0027-8424
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PubMed ID | 3470801
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PubMed Central ID | PMC304651
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