Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.

Nat Genet
Authors
Keywords
Abstract

Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.

Year of Publication
1996
Journal
Nat Genet
Volume
12
Issue
1
Pages
31-7
Date Published
1996 Jan
ISSN
1061-4036
DOI
10.1038/ng0196-31
PubMed ID
8528247
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