Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.
Nat Genet
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Abstract | Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases. |
Year of Publication | 1996
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Journal | Nat Genet
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Volume | 12
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Issue | 1
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Pages | 31-7
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Date Published | 1996 Jan
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ISSN | 1061-4036
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DOI | 10.1038/ng0196-31
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PubMed ID | 8528247
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