Discovery of common and rare genetic risk variants for colorectal cancer.

Nat Genet
Authors
Keywords
Abstract

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P 

Year of Publication
2019
Journal
Nat Genet
Volume
51
Issue
1
Pages
76-87
Date Published
2019 Jan
ISSN
1546-1718
DOI
10.1038/s41588-018-0286-6
PubMed ID
30510241
PubMed Central ID
PMC6358437
Links
Grant list
P30 CA015704 / CA / NCI NIH HHS / United States
K01 DK110267 / DK / NIDDK NIH HHS / United States
P30 DK058404 / DK / NIDDK NIH HHS / United States
U01 CA164930 / CA / NCI NIH HHS / United States
U01 CA074794 / CA / NCI NIH HHS / United States
R01 CA207371 / CA / NCI NIH HHS / United States
P30 CA016058 / CA / NCI NIH HHS / United States
K05 CA152715 / CA / NCI NIH HHS / United States
S10 OD020069 / OD / NIH HHS / United States
MR/L01629X/1 / MRC_ / Medical Research Council / United Kingdom
P01 CA196569 / CA / NCI NIH HHS / United States
10119 / CRUK_ / Cancer Research UK / United Kingdom
U19 CA148107 / CA / NCI NIH HHS / United States
10589 / CRUK_ / Cancer Research UK / United Kingdom
R01 CA059045 / CA / NCI NIH HHS / United States
R01 CA197350 / CA / NCI NIH HHS / United States
10124 / CRUK_ / Cancer Research UK / United Kingdom
R35 CA197735 / CA / NCI NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
R01 CA204279 / CA / NCI NIH HHS / United States
U10 CA037429 / CA / NCI NIH HHS / United States
U01 CA182883 / CA / NCI NIH HHS / United States
R01 CA160356 / CA / NCI NIH HHS / United States
UG1 CA189974 / CA / NCI NIH HHS / United States
R01 CA189184 / CA / NCI NIH HHS / United States
U01 CA137088 / CA / NCI NIH HHS / United States
K23 DK103119 / DK / NIDDK NIH HHS / United States
U24 CA074794 / CA / NCI NIH HHS / United States
R21 CA191312 / CA / NCI NIH HHS / United States
U01 CA206110 / CA / NCI NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
10822 / CRUK_ / Cancer Research UK / United Kingdom
U01 CA167551 / CA / NCI NIH HHS / United States
U01 CA185094 / CA / NCI NIH HHS / United States
P30 CA014089 / CA / NCI NIH HHS / United States
R01 CA081488 / CA / NCI NIH HHS / United States
R01 CA143237 / CA / NCI NIH HHS / United States
R01 CA201407 / CA / NCI NIH HHS / United States
UM1 CA182883 / CA / NCI NIH HHS / United States
HHSN268201200008I / HL / NHLBI NIH HHS / United States
U01 CA152756 / CA / NCI NIH HHS / United States
R01 CA193677 / CA / NCI NIH HHS / United States