Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.
Nat Neurosci
Authors | |
Abstract | Disruptive, damaging ultra-rare variants in highly constrained genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of education (YOE). This effect was stronger among highly brain-expressed genes and explained more YOE variance than pathogenic copy number variation but less than common variants. Disruptive, damaging ultra-rare variants in highly constrained genes influence the determinants of YOE in the general population. |
Year of Publication | 2016
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Journal | Nat Neurosci
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Volume | 19
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Issue | 12
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Pages | 1563-1565
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Date Published | 2016 Dec
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ISSN | 1546-1726
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DOI | 10.1038/nn.4404
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PubMed ID | 27694993
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PubMed Central ID | PMC5127781
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Links | |
Grant list | P50 HD028138 / HD / NICHD NIH HHS / United States
U54 HG003067 / HG / NHGRI NIH HHS / United States
RC2 MH089905 / MH / NIMH NIH HHS / United States
R01 MH077139 / MH / NIMH NIH HHS / United States
R01 MH094469 / MH / NIMH NIH HHS / United States
U01 MH105666 / MH / NIMH NIH HHS / United States
T32 HL007208 / HL / NHLBI NIH HHS / United States
R01 HG006855 / HG / NHGRI NIH HHS / United States
R01 MH107649 / MH / NIMH NIH HHS / United States
R01 MH101244 / MH / NIMH NIH HHS / United States
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