is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.

Neurology
Authors
Keywords
Abstract

OBJECTIVE: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD.

METHODS: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (, , , , , and ) with intracerebral hemorrhage (ICH) (deep, lobar, all; 1,878 cases, 2,830 controls) and ischemic stroke (IS) (lacunar, cardioembolic, large vessel disease, all; 19,569 cases, 37,853 controls). We applied data quality filters and set statistical significance thresholds accounting for linkage disequilibrium and multiple testing.

RESULTS: A locus in was associated (significance threshold

CONCLUSIONS: These results provide evidence of shared genetic determinants and suggest common pathophysiologic mechanisms of distinct ischemic and hemorrhagic cerebral SVD stroke phenotypes, offering new insights into the causal mechanisms of cerebral SVD.

Year of Publication
2017
Journal
Neurology
Volume
89
Issue
17
Pages
1829-1839
Date Published
2017 Oct 24
ISSN
1526-632X
DOI
10.1212/WNL.0000000000004560
PubMed ID
28954878
PubMed Central ID
PMC5664302
Links
Grant list
U01 AG009740 / AG / NIA NIH HHS / United States
UL1 TR001863 / TR / NCATS NIH HHS / United States
K23 NS100816 / NS / NINDS NIH HHS / United States
KL2 TR001429 / TR / NCATS NIH HHS / United States
R01 HL088521 / HL / NHLBI NIH HHS / United States
U01 NS036695 / NS / NINDS NIH HHS / United States