You are here

Curr Opin Microbiol DOI:10.1016/j.mib.2017.09.002

Antibiotic efficacy-context matters.

Publication TypeJournal Article
Year of Publication2017
AuthorsYang, JH, Bening, SC, Collins, JJ
JournalCurr Opin Microbiol
Volume39
Pages73-80
Date Published2017 Oct 16
ISSN1879-0364
Abstract

Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each contribute to antibiotic-induced cell death. Moreover, environmental factors such as oxygen availability, extracellular metabolites, population heterogeneity and multidrug contexts alter antibiotic efficacy by impacting bacterial metabolism and stress responses. Here we review recent studies on antibiotic efficacy and highlight insights gained on the involvement of cellular respiration, redox stress and altered metabolism in antibiotic lethality. We discuss the complexity found in natural environments and highlight knowledge gaps in antibiotic lethality that may be addressed using systems approaches.

DOI10.1016/j.mib.2017.09.002
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/29049930?dopt=Abstract

Alternate JournalCurr. Opin. Microbiol.
PubMed ID29049930