A genetic map of the mouse suitable for typing intraspecific crosses.

Genetics

Authors	W Dietrich H Katz S Lincoln H Shin Friedman N Dracopoli E Lander
Keywords	Animals Mice Base Sequence Genetic Markers Genome Polymerase Chain Reaction Molecular Sequence Data Chromosome Mapping Genetic Linkage Repetitive Sequences, Nucleic Acid Polymorphism, Restriction Fragment Length Mice, Inbred Strains
Abstract	We report the construction of a genetic linkage map of the mouse, consisting entirely of genetic markers that can be rapidly typed by polymerase chain reaction and that show a high degree of polymorphism among inbred laboratory strains. Specifically, the map contains 317 simple sequence length polymorphisms at an average spacing of 4.3 cM and is detectably linked to approximately 99% of the mouse genome. In typical crosses between inbred laboratory strains, about 50% of the markers are polymorphic, making it straightforward to follow inheritance in almost any cross.
Year of Publication	1992
Journal	Genetics
Volume	131
Issue	2
Pages	423-47
Date Published	1992 Jun
ISSN	0016-6731
PubMed ID	1353738
PubMed Central ID	PMC1205016
Links	Google Scholar PubMed
Grant list	P50HG00098 / HG / NHGRI NIH HHS / United States R01HG00126 / HG / NHGRI NIH HHS / United States R01HG00316 / HG / NHGRI NIH HHS / United States