A genetic linkage map of the human genome.

Cell

Authors	H Donis-Keller P Green C Helms S Cartinhour B Weiffenbach K Stephens T Keith D Bowden D Smith E Lander
Keywords	Humans Genes Chromosome Mapping Polymorphism, Genetic Recombination, Genetic Pedigree Genetic Linkage Sex Characteristics
Abstract	We report the construction of a linkage map of the human genome, based on the pattern of inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three-generation families. By a combination of mathematical linkage analysis and physical localization of selected clones, it was possible to arrange these loci into linkage groups representing 23 human chromosomes. We estimate that the linkage map is detectably linked to at least 95% of the DNA in the human genome.
Year of Publication	1987
Journal	Cell
Volume	51
Issue	2
Pages	319-37
Date Published	1987 Oct 23
ISSN	0092-8674
PubMed ID	3664638
Links	Google Scholar PubMed
Grant list	AM37656-01 / AM / NIADDK NIH HHS / United States