Tolerogenic dendritic cells.

Semin Immunopathol
Authors
Abstract

Deficits in immunological tolerance against self-antigens and antigens provided by the diet and commensal microbiota can result in the development of inflammatory and autoimmune disorders. Dendritic cells (DCs) are pivotal regulators of the immune response, specialized in antigen presentation to drive T cell priming and differentiation. DCs also have a tolerogenic function, participating in the enforcement of central and peripheral tolerance and the resolution of ongoing immune responses. Thus, DCs control effector and regulatory mechanisms relevant to the pathology of autoimmune disorders. In this review, we discuss recent findings regarding the control of the adaptive immune response by tolerogenic DCs. A thorough understanding of the mechanisms that control the tolerogenic DC phenotype will guide the development of novel strategies for the treatment of autoimmunity.

Year of Publication
2017
Journal
Semin Immunopathol
Volume
39
Issue
2
Pages
113-120
Date Published
2017 Feb
ISSN
1863-2300
DOI
10.1007/s00281-016-0587-8
PubMed ID
27646959
PubMed Central ID
PMC5296314
Links
Grant list
R01 AI093903 / AI / NIAID NIH HHS / United States
R01 ES025530 / ES / NIEHS NIH HHS / United States
R21 NS087867 / NS / NINDS NIH HHS / United States
R56 AI093903 / AI / NIAID NIH HHS / United States