Emerging roles of p53 and other tumour-suppressor genes in immune regulation.

Nat Rev Immunol
Authors
Abstract

Tumour-suppressor genes are indispensable for the maintenance of genomic integrity. Recently, several of these genes, including those encoding p53, PTEN, RB1 and ARF, have been implicated in immune responses and inflammatory diseases. In particular, the p53 tumour- suppressor pathway is involved in crucial aspects of tumour immunology and in homeostatic regulation of immune responses. Other studies have identified roles for p53 in various cellular processes, including metabolism and stem cell maintenance. Here, we discuss the emerging roles of p53 and other tumour-suppressor genes in tumour immunology, as well as in additional immunological settings, such as virus infection. This relatively unexplored area could yield important insights into the homeostatic control of immune cells in health and disease and facilitate the development of more effective immunotherapies. Consequently, tumour-suppressor genes are emerging as potential guardians of immune integrity.

Year of Publication
2016
Journal
Nat Rev Immunol
Volume
16
Issue
12
Pages
741-750
Date Published
2016 12
ISSN
1474-1741
DOI
10.1038/nri.2016.99
PubMed ID
27667712
Links
Grant list
R01 CA195534 / CA / NCI NIH HHS / United States
R01 CA203552 / CA / NCI NIH HHS / United States