Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.

Cell
Authors
Keywords
Abstract

We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice.

Year of Publication
2017
Journal
Cell
Volume
169
Issue
6
Pages
1029-1041.e16
Date Published
2017 Jun 01
ISSN
1097-4172
DOI
10.1016/j.cell.2017.05.024
PubMed ID
28575667
PubMed Central ID
PMC5520675
Links
Grant list
R01 MH100186 / MH / NIMH NIH HHS / United States
R21 NS085491 / NS / NINDS NIH HHS / United States
R01 NS051874 / NS / NINDS NIH HHS / United States
R21 NS082870 / NS / NINDS NIH HHS / United States
R01 NS073601 / NS / NINDS NIH HHS / United States
R01 MH103910 / MH / NIMH NIH HHS / United States
R21 MH099196 / MH / NIMH NIH HHS / United States
R01 HD069776 / HD / NICHD NIH HHS / United States
RF1 AG047661 / AG / NIA NIH HHS / United States
R21 NS103098 / NS / NINDS NIH HHS / United States
DP1 NS087724 / NS / NINDS NIH HHS / United States
UL1 RR025758 / RR / NCRR NIH HHS / United States
Wellcome Trust / United Kingdom
R37 NS051874 / NS / NINDS NIH HHS / United States