Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.

Hum Mol Genet
Authors
Keywords
Abstract

Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Its prevalence and severity vary across ancestral background. Although OSA traits are heritable, few genetic associations have been identified. To identify genetic regions associated with OSA and improve statistical power, we applied admixture mapping on three primary OSA traits [the apnea hypopnea index (AHI), overnight average oxyhemoglobin saturation (SaO2) and percentage time SaO2 

Year of Publication
2019
Journal
Hum Mol Genet
Volume
28
Issue
4
Pages
675-687
Date Published
2019 Feb 15
ISSN
1460-2083
DOI
10.1093/hmg/ddy387
PubMed ID
30403821
PubMed Central ID
PMC6360325
Links
Grant list
HHSN268201100010C / HL / NHLBI NIH HHS / United States
UL1 TR000128 / TR / NCATS NIH HHS / United States
HHSN268201200036C / HL / NHLBI NIH HHS / United States
KL2 RR024990 / RR / NCRR NIH HHS / United States
U01 AG027810 / AG / NIA NIH HHS / United States
U01 DK085501 / DK / NIDDK NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
UL1 RR033176 / RR / NCRR NIH HHS / United States
HHSN268201300005C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201500003C / HL / NHLBI NIH HHS / United States
P50 HL056984 / HL / NHLBI NIH HHS / United States
R01 HG003054 / HG / NHGRI NIH HHS / United States
N01HC95160 / HL / NHLBI NIH HHS / United States
HHSN263201500003I / NH / NIH HHS / United States
R01 HL070848 / HL / NHLBI NIH HHS / United States
R01 HL046380 / HL / NHLBI NIH HHS / United States
R01 HL071194 / HL / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
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UL1 TR001079 / TR / NCATS NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
R01 HL070847 / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
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R01 HL113338 / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
N01 HC085084 / HC / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
N01 HC085085 / HC / NHLBI NIH HHS / United States
R01 HL070842 / HL / NHLBI NIH HHS / United States
HHSN268201300048C / HL / NHLBI NIH HHS / United States
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N01HC65235 / HL / NHLBI NIH HHS / United States
R01 HL087652 / HL / NHLBI NIH HHS / United States
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UL1 TR000124 / TR / NCATS NIH HHS / United States
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HHSN268201100005I / HL / NHLBI NIH HHS / United States
U01 AG042168 / AG / NIA NIH HHS / United States
N01HC95165 / HL / NHLBI NIH HHS / United States
N01HC95159 / HL / NHLBI NIH HHS / United States
R01 HL070841 / HL / NHLBI NIH HHS / United States
N01HC95161 / HL / NHLBI NIH HHS / United States
HHSN268201300047C / HL / NHLBI NIH HHS / United States
UL1 TR001420 / TR / NCATS NIH HHS / United States
U01 AG042140 / AG / NIA NIH HHS / United States
R01 HL070838 / HL / NHLBI NIH HHS / United States
HHSN268201300050C / HL / NHLBI NIH HHS / United States
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RC2 AR058973 / AR / NIAMS NIH HHS / United States
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HHSN268201300046C / HL / NHLBI NIH HHS / United States
N01HC95166 / HL / NHLBI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
N01HC85080 / HL / NHLBI NIH HHS / United States
R01 HL070837 / HL / NHLBI NIH HHS / United States
U54 GM115428 / GM / NIGMS NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
U01 AG042143 / AG / NIA NIH HHS / United States
U01 AG042139 / AG / NIA NIH HHS / United States
P30 DK020595 / DK / NIDDK NIH HHS / United States
N01HC85081 / HL / NHLBI NIH HHS / United States
K01 HL135405 / HL / NHLBI NIH HHS / United States
U01 AR066160 / AR / NIAMS NIH HHS / United States