Murine Norovirus Infection Induces T1 Inflammatory Responses to Dietary Antigens.

Cell Host Microbe
Authors
Keywords
Abstract

Intestinal reovirus infection can trigger T helper 1 (T1) immunity to dietary antigen, raising the question of whether other viruses can have a similar impact. Here we show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces T1 immunity to dietary antigen. This property of CW3 is dependent on its major capsid protein, a virulence determinant. Transcriptional profiling of mesenteric lymph nodes following infection reveals an immunopathological signature that does not segregate with protective immunity but with loss of oral tolerance, in which interferon regulatory factor 1 is critical. These data show that viral capacity to trigger specific inflammatory pathways at sites where T cell responses to dietary antigens take place interferes with the development of tolerance to an oral antigen. Collectively, these data provide a foundation for the development of therapeutic strategies to prevent T1-mediated complex immune disorders triggered by viral infections.

Year of Publication
2018
Journal
Cell Host Microbe
Volume
24
Issue
5
Pages
677-688.e5
Date Published
2018 Nov 14
ISSN
1934-6069
DOI
10.1016/j.chom.2018.10.004
PubMed ID
30392830
PubMed Central ID
PMC6326098
Links
Grant list
R01 AI127518 / AI / NIAID NIH HHS / United States
P30 DK042086 / DK / NIDDK NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
P30 CA014599 / CA / NCI NIH HHS / United States
T32 GM007281 / GM / NIGMS NIH HHS / United States
R25 GM109439 / GM / NIGMS NIH HHS / United States
T32 AI007090 / AI / NIAID NIH HHS / United States
DP2 CA225208 / CA / NCI NIH HHS / United States
T32 GM007183 / GM / NIGMS NIH HHS / United States
R01 DK098435 / DK / NIDDK NIH HHS / United States