The role of Gdf5 regulatory regions in development of hip morphology.

PLoS One
Authors
Keywords
Abstract

Given GDF5 involvement in hip development, and osteoarthritis (OA) and developmental hip dysplasia (DDH) risk, here we sought to assess the role(s) of GDF5 and its regulatory sequence on the development of hip morphology linked to injury risk. The brachypodism (bp) mouse, which harbors a Gdf5 inactivating mutation, was used to survey how Gdf5 loss of function impacts the development of hip morphology. Two transgenic Gdf5 reporter BAC lines were used to assess the spatiotemporal expression of Gdf5 regulatory sequences. Each BAC line was also used to assess the functional roles of upstream and downstream sequence on hip morphology. bp/bp mice had shorter femora with smaller femoral heads and necks as well as larger alpha angles, smaller anterior offsets, and smaller acetabula, compared to bp/+ mice (p

Year of Publication
2018
Journal
PLoS One
Volume
13
Issue
11
Pages
e0202785
Date Published
2018
ISSN
1932-6203
DOI
10.1371/journal.pone.0202785
PubMed ID
30388100
PubMed Central ID
PMC6214493
Links
Grant list
P30 AR066261 / AR / NIAMS NIH HHS / United States
R01 AR065462 / AR / NIAMS NIH HHS / United States
R01 AR070139 / AR / NIAMS NIH HHS / United States