A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies.
ACS Infect Dis
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Abstract | Computer-aided screening of antimicrobial peptides (AMPs) is a promising approach for discovering novel therapies against multidrug-resistant bacterial infections. Here, we functionally and structurally characterized an Escherichia coli-derived AMP (EcDBS1R5) previously designed through pattern identification [α-helical set (KK[ILV][AILV])], followed by sequence optimization. EcDBS1R5 inhibited the growth of Gram-negative and Gram-positive, susceptible and resistant bacterial strains at low doses (2-32 μM), with no cytotoxicity observed against non-cancerous and cancerous cell lines in the concentration range analyzed ( |
Year of Publication | 2018
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Journal | ACS Infect Dis
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Volume | 4
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Issue | 12
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Pages | 1727-1736
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Date Published | 2018 Dec 14
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ISSN | 2373-8227
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DOI | 10.1021/acsinfecdis.8b00219
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PubMed ID | 30346140
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