An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

Diabetes
Authors
Robert Scott
Laura Scott
Reedik Mägi
Letizia Marullo
Kyle Gaulton
Marika Kaakinen
Natalia Pervjakova
Tune Pers
Andrew Johnson
John Eicher
Anne Jackson
Teresa Ferreira
Yeji Lee
Clement Ma
Valgerdur Steinthorsdottir
Gudmar Thorleifsson
Lu Qi
Natalie van Zuydam
Anubha Mahajan
Han Chen
Peter Almgren
Ben Voight
Harald Grallert
Martina Müller-Nurasyid
Janina Ried
Nigel Rayner
Neil Robertson
Lennart Karssen
Elisabeth van Leeuwen
Sara Willems
Christian Fuchsberger
Phoenix Kwan
Tanya Teslovich
Pritam Chanda
Man Li
Yingchang Lu
Christian Dina
Dorothee Thuillier
Loic Yengo
Longda Jiang
Thomas Sparso
Hans Kestler
Himanshu Chheda
Lewin Eisele
Stefan Gustafsson
Mattias Frånberg
Rona Strawbridge
Rafn Benediktsson
Astradur Hreidarsson
Augustine Kong
Gunnar Sigurðsson
Nicola Kerrison
Jian'an Luan
Liming Liang
Thomas Meitinger
Michael Roden
Barbara Thorand
Tõnu Esko
Evelin Mihailov
Caroline Fox
Ching-Ti Liu
Denis Rybin
Bo Isomaa
Valeriya Lyssenko
Tiinamaija Tuomi
David Couper
James Pankow
Niels Grarup
Christian Have
Marit Jørgensen
Torben Jørgensen
Allan Linneberg
Marilyn Cornelis
Rob van Dam
David Hunter
Peter Kraft
Qi Sun
Sarah Edkins
Katharine Owen
John Perry
Andrew Wood
Eleftheria Zeggini
Juan Tajes-Fernandes
Gonçalo Abecasis
Lori Bonnycastle
Peter Chines
Heather Stringham
Heikki Koistinen
Leena Kinnunen
Bengt Sennblad
Thomas Mühleisen
Markus Nöthen
Sonali Pechlivanis
Damiano Baldassarre
Karl Gertow
Steve Humphries
Elena Tremoli
Norman Klopp
Julia Meyer
Gerald Steinbach
Roman Wennauer
Johan Eriksson
Satu Mӓnnistö
Leena Peltonen
Emmi Tikkanen
Guillaume Charpentier
Elodie Eury
Stéphane Lobbens
Bruna Gigante
Karin Leander
Olga McLeod
Erwin Bottinger
Omri Gottesman
Douglas Ruderfer
Matthias Blüher
Peter Kovacs
Anke Tönjes
Nisa Maruthur
Chiara Scapoli
Raimund Erbel
Karl-Heinz Jöckel
Susanne Moebus
Ulf de Faire
Anders Hamsten
Michael Stumvoll
Panagiotis Deloukas
Peter Donnelly
Timothy Frayling
Andrew Hattersley
Samuli Ripatti
Veikko Salomaa
Nancy Pedersen
Bernhard Boehm
Richard Bergman
Francis Collins
Karen Mohlke
Jaakko Tuomilehto
Torben Hansen
Oluf Pedersen
Inês Barroso
Lars Lannfelt
Erik Ingelsson
Lars Lind
Cecilia Lindgren
Stephane Cauchi
Philippe Froguel
Ruth Loos
Beverley Balkau
Heiner Boeing
Paul Franks
Aurelio Gurrea
Domenico Palli
Yvonne van der Schouw
David Altshuler
Leif Groop
Claudia Langenberg
Nicholas Wareham
Eric Sijbrands
Cornelia van Duijn
Jose Florez
James Meigs
Eric Boerwinkle
Christian Gieger
Konstantin Strauch
Andres Metspalu
Andrew Morris
Colin Palmer
Frank Hu
Unnur Thorsteinsdottir
Kari Stefansson
Josée Dupuis
Andrew Morris
Michael Boehnke
Mark McCarthy
Inga Prokopenko
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Keywords
Humans
Gene Expression Regulation
Genome-Wide Association Study
Genetic Variation
European Continental Ancestry Group
Diabetes Mellitus, Type 2
Abstract

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (

Year of Publication
2017
Journal
Diabetes
Volume
66
Issue
11
Pages
2888-2902
Date Published
2017 11
ISSN
1939-327X
DOI
10.2337/db16-1253
PubMed ID
28566273
PubMed Central ID
PMC5652602
Links
Grant list
R01 DK078616 / DK / NIDDK NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
U01 HG007417 / HG / NHGRI NIH HHS / United States
R01 DK073490 / DK / NIDDK NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
098017 / Wellcome Trust / United Kingdom
R01 DK058845 / DK / NIDDK NIH HHS / United States
RG/08/008/25291 / British Heart Foundation / United Kingdom
N01HG65403 / HG / NHGRI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
U01 DK085545 / DK / NIDDK NIH HHS / United States
R01 DK106236 / DK / NIDDK NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
R01 DK098032 / DK / NIDDK NIH HHS / United States
ZIA HG000024 / HG / NHGRI NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
R01 HG000376 / HG / NHGRI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
S10 OD018522 / OD / NIH HHS / United States
MC_UU_12015/1 / Medical Research Council / United Kingdom
U01 DK105535 / DK / NIDDK NIH HHS / United States
R01 DK101478 / DK / NIDDK NIH HHS / United States
P30 DK046200 / DK / NIDDK NIH HHS / United States
R01 AG028555 / AG / NIA NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
MC_UU_12015/2 / Medical Research Council / United Kingdom
HHSN268201100005I / HL / NHLBI NIH HHS / United States
RC2 DK088389 / DK / NIDDK NIH HHS / United States
K24 DK080140 / DK / NIDDK NIH HHS / United States
UM1 CA186107 / CA / NCI NIH HHS / United States
U01 DK085526 / DK / NIDDK NIH HHS / United States
P30 DK020541 / DK / NIDDK NIH HHS / United States
MR/M501633/2 / Medical Research Council / United Kingdom
U01 DK078616 / DK / NIDDK NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
UM1 CA167552 / CA / NCI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
RG/14/5/30893 / British Heart Foundation / United Kingdom
MR/K007017/1 / Medical Research Council / United Kingdom
Wellcome Trust / United Kingdom
R01 AG033067 / AG / NIA NIH HHS / United States
MC_PC_13040 / Medical Research Council / United Kingdom
R01 HL087641 / HL / NHLBI NIH HHS / United States
G0601261 / Medical Research Council / United Kingdom
R01 AG010175 / AG / NIA NIH HHS / United States
U01 HG004399 / HG / NHGRI NIH HHS / United States
MR/M501633/1 / Medical Research Council / United Kingdom

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