Epigenetics and Epigenomics: Implications for Diabetes and Obesity.
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Abstract | The American Diabetes Association convened a research symposium, "Epigenetics and Epigenomics: Implications for Diabetes and Obesity" on 17-19 November 2017. International experts in genetics, epigenetics, computational biology, and physiology discussed the current state of understanding of the relationships between genetics, epigenetics, and environment in diabetes and examined existing evidence for the role of epigenetic factors in regulating metabolism and the risk of diabetes and its complications. The authors summarize the presentations, which highlight how the complex interactions between genes and environment may in part be mediated through epigenetic changes and how information about nutritional and other environmental stimuli can be transmitted to the next generation. In addition, the authors present expert consensus on knowledge gaps and research recommendations for the field. |
Year of Publication | 2018
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Journal | Diabetes
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Volume | 67
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Issue | 10
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Pages | 1923-1931
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Date Published | 2018 10
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ISSN | 1939-327X
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DOI | 10.2337/db18-0537
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PubMed ID | 30237160
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PubMed Central ID | PMC6463748
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Grant list | DP3 DK108220 / DK / NIDDK NIH HHS / United States
R01 DK106193 / DK / NIDDK NIH HHS / United States
R01 DK087635 / DK / NIDDK NIH HHS / United States
P30 DK036836 / DK / NIDDK NIH HHS / United States
DP3 DK106917 / DK / NIDDK NIH HHS / United States
R01 DK065073 / DK / NIDDK NIH HHS / United States
R01 HL106089 / HL / NHLBI NIH HHS / United States
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