Dietary Fat Intake after Colon Cancer Diagnosis in Relation to Cancer Recurrence and Survival: CALGB 89803 (Alliance).

Cancer Epidemiol Biomarkers Prev
Authors
Keywords
Abstract

Higher intake of long-chain ω-3 polyunsaturated fatty acids and nuts, rich plant sources of unsaturated fats, after colon cancer diagnosis are associated with improved survival. It is not known whether the amount or the distribution of other types of fat is associated with survival after colon cancer. We prospectively examined postdiagnostic total, animal, and vegetable fats, as well as the saturated, monounsaturated, polyunsaturated, and fat in relation to disease-free survival among 1,011 patients with stage III colon cancer. Patients were enrolled between 1999 and 2001 at the onset of adjuvant chemotherapy and followed for recurrence or death through 2009. During median follow-up of 7 years, we observed 305 deaths and 81 recurrences (total events: 386). Neither total nor any specific type of dietary fat examined was statistically significantly associated with risk of cancer recurrence or death from any cause (disease-free survival) after stage III colon cancer. The amount and type (animal, vegetable, saturated, monounsaturated, polyunsaturated, and ) of dietary fat consumed after colon cancer does not appear to be substantially associated with risk of recurrence or survival. Neither total nor major types (animal, vegetable, saturated, monounsaturated, polyunsaturated, and ) of dietary fat consumed after colon cancer was associated with cancer recurrence or survival. .

Year of Publication
2018
Journal
Cancer Epidemiol Biomarkers Prev
Volume
27
Issue
10
Pages
1227-1230
Date Published
2018 10
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-18-0487
PubMed ID
30038051
PubMed Central ID
PMC6170705
Links
Grant list
R35 CA197735 / CA / NCI NIH HHS / United States
R01 CA118553 / CA / NCI NIH HHS / United States
R01 CA149222 / CA / NCI NIH HHS / United States
UG1 CA189974 / CA / NCI NIH HHS / United States
U10 CA180821 / CA / NCI NIH HHS / United States
K07 CA197077 / CA / NCI NIH HHS / United States
UG1 CA189858 / CA / NCI NIH HHS / United States
U10 CA180882 / CA / NCI NIH HHS / United States
U10 CA180820 / CA / NCI NIH HHS / United States
U10 CA180867 / CA / NCI NIH HHS / United States
U10 CA138561 / CA / NCI NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
U10 CA180791 / CA / NCI NIH HHS / United States
K99 CA215314 / CA / NCI NIH HHS / United States
R00 CA215314 / CA / NCI NIH HHS / United States
U10 CA180888 / CA / NCI NIH HHS / United States
P50 CA127003 / CA / NCI NIH HHS / United States