Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Nat Genet
Authors
Evangelos Evangelou
Helen Warren
David Mosen-Ansorena
Borbala Mifsud
Raha Pazoki
He Gao
Georgios Ntritsos
Niki Dimou
Claudia Cabrera
Ibrahim Karaman
Fu Ng
Marina Evangelou
Katarzyna Witkowska
Evan Tzanis
Jacklyn Hellwege
Ayush Giri
Digna Edwards
Yan Sun
Kelly Cho
J Michael Gaziano
Peter Wilson
Philip Tsao
Csaba Kovesdy
Tõnu Esko
Reedik Mägi
Lili Milani
Peter Almgren
Thibaud Boutin
Stéphanie Debette
Jun Ding
Franco Giulianini
Elizabeth Holliday
Anne Jackson
Ruifang Li-Gao
Wei-Yu Lin
Jian'an Luan
Massimo Mangino
Christopher Oldmeadow
Bram Prins
Yong Qian
Muralidharan Sargurupremraj
Nabi Shah
Praveen Surendran
Sébastien Thériault
Niek Verweij
Sara Willems
Jing-Hua Zhao
Philippe Amouyel
John Connell
Renée de Mutsert
Alex Doney
Martin Farrall
Cristina Menni
Andrew Morris
Raymond Noordam
Guillaume Pare
Neil Poulter
Denis Shields
Alice Stanton
Simon Thom
Goncalo Abecasis
Najaf Amin
Dan Arking
Kristin Ayers
Caterina Barbieri
Chiara Batini
Joshua Bis
Tineka Blake
Murielle Bochud
Michael Boehnke
Eric Boerwinkle
Dorret Boomsma
Erwin Bottinger
Peter Braund
Marco Brumat
Archie Campbell
Harry Campbell
Aravinda Chakravarti
John Chambers
Ganesh Chauhan
Marina Ciullo
Massimiliano Cocca
Francis Collins
Heather Cordell
Gail Davies
Martin de Borst
Eco de Geus
Ian Deary
Joris Deelen
Fabiola M
Cumhur Demirkale
Marcus Dorr
Georg Ehret
Roberto Elosua
Stefan Enroth
A Mesut Erzurumluoglu
Teresa Ferreira
Mattias Frånberg
Oscar Franco
Ilaria Gandin
Paolo Gasparini
Vilmantas Giedraitis
Christian Gieger
Giorgia Girotto
Anuj Goel
Alan Gow
Vilmundur Gudnason
Xiuqing Guo
Ulf Gyllensten
Anders Hamsten
Tamara Harris
Sarah Harris
Catharina Hartman
Aki Havulinna
Andrew Hicks
Edith Hofer
Albert Hofman
Jouke-Jan Hottenga
Jennifer Huffman
Shih-Jen Hwang
Erik Ingelsson
Alan James
Rick Jansen
Marjo-Riitta Jarvelin
Roby Joehanes
Asa Johansson
Andrew Johnson
Peter Joshi
Pekka Jousilahti
J Wouter Jukema
Antti Jula
Mika Kähönen
Sekar Kathiresan
Bernard Keavney
Kay-Tee Khaw
Paul Knekt
Joanne Knight
Ivana Kolcic
Jaspal Kooner
Seppo Koskinen
Kati Kristiansson
Zoltán Kutalik
Maris Laan
Marty Larson
Lenore Launer
Benjamin Lehne
Terho Lehtimäki
David Liewald
Li Lin
Lars Lind
Cecilia Lindgren
Yongmei Liu
Ruth Loos
Lorna Lopez
Yingchang Lu
Leo-Pekka Lyytikäinen
Anubha Mahajan
Chrysovalanto Mamasoula
Jaume Marrugat
Jonathan Marten
Yuri Milaneschi
Anna Morgan
Andrew Morris
Alanna Morrison
Peter Munson
Mike Nalls
Priyanka Nandakumar
Christopher Nelson
Teemu Niiranen
Ilja Nolte
Teresa Nutile
Albertine Oldehinkel
Ben Oostra
Paul O'Reilly
Elin Org
Sandosh Padmanabhan
Walter Palmas
Aarno Palotie
Alison Pattie
Brenda Penninx
Markus Perola
Annette Peters
Ozren Polasek
Peter Pramstaller
Quang Nguyen
Olli Raitakari
Meixia Ren
Rainer Rettig
Kenneth Rice
Paul Ridker
Janina Ried
Harriëtte Riese
Samuli Ripatti
Antonietta Robino
Lynda Rose
Jerome Rotter
Igor Rudan
Daniela Ruggiero
Yasaman Saba
Cinzia Sala
Veikko Salomaa
Nilesh Samani
Antti-Pekka Sarin
Reinhold Schmidt
Helena Schmidt
Nick Shrine
David Siscovick
Albert Smith
Harold Snieder
Siim Sõber
Rossella Sorice
John Starr
David Stott
David Strachan
Rona Strawbridge
Johan Sundstrom
Morris Swertz
Kent Taylor
Alexander Teumer
Martin Tobin
Maciej Tomaszewski
Daniela Toniolo
Michela Traglia
Stella Trompet
Jaakko Tuomilehto
Christophe Tzourio
André Uitterlinden
Ahmad Vaez
Peter van der Most
Cornelia van Duijn
Anne-Claire Vergnaud
Germaine Verwoert
Veronique Vitart
Uwe Volker
Peter Vollenweider
Dragana Vuckovic
Hugh Watkins
Sarah Wild
Gonneke Willemsen
James Wilson
Alan Wright
Jie Yao
Tatijana Zemunik
Weihua Zhang
John Attia
Adam Butterworth
Daniel Chasman
David Conen
Francesco Cucca
John Danesh
Caroline Hayward
Joanna Howson
Markku Laakso
Edward Lakatta
Claudia Langenberg
Olle Melander
Dennis Mook-Kanamori
Colin Palmer
Lorenz Risch
Robert Scott
Rodney Scott
Peter Sever
Tim Spector
Pim van der Harst
Nicholas Wareham
Eleftheria Zeggini
Daniel Levy
Patricia Munroe
Christopher Newton-Cheh
Morris Brown
Andres Metspalu
Adriana Hung
Christopher O'Donnell
Todd Edwards
Bruce Psaty
Ioanna Tzoulaki
Michael Barnes
Louise Wain
Paul Elliott
Mark Caulfield
Million Veteran Program
Keywords
Female
Humans
Male
Adult
Aged
Genetic Predisposition to Disease
Middle Aged
Risk Factors
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Cells, Cultured
Genetic Loci
Genetics, Population
Genetic Testing
Aged, 80 and over
Blood Pressure
Hypertension
Cardiovascular Diseases
Human Umbilical Vein Endothelial Cells
Life Style
Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Year of Publication
2018
Journal
Nat Genet
Volume
50
Issue
10
Pages
1412-1425
Date Published
2018 10
ISSN
1546-1718
DOI
10.1038/s41588-018-0205-x
PubMed ID
30224653
PubMed Central ID
PMC6284793
Links
Grant list
MR/L003120/1 / MRC_ / Medical Research Council / United Kingdom
RG/13/13/30194 / BHF_ / British Heart Foundation / United Kingdom
U01 HL130114 / HL / NHLBI NIH HHS / United States
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK110113 / DK / NIDDK NIH HHS / United States
MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom
MR/K007017/1 / MRC_ / Medical Research Council / United Kingdom
R21 HL121429 / HL / NHLBI NIH HHS / United States
M01 RR000070 / RR / NCRR NIH HHS / United States
U01 DK102163 / DK / NIDDK NIH HHS / United States
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
FS/12/82/29736 / BHF_ / British Heart Foundation / United Kingdom
U01 HG007417 / HG / NHGRI NIH HHS / United States
SP/13/2/30111 / BHF_ / British Heart Foundation / United Kingdom
R01 HL120393 / HL / NHLBI NIH HHS / United States
U01 HL120393 / HL / NHLBI NIH HHS / United States
T32 CA160056 / CA / NCI NIH HHS / United States
MR/N01104X/2 / MRC_ / Medical Research Council / United Kingdom
G1001799 / MRC_ / Medical Research Council / United Kingdom
MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom
MC_PC_13040 / MRC_ / Medical Research Council / United Kingdom
R01 DK107786 / DK / NIDDK NIH HHS / United States
MR/S003061/1 / MRC_ / Medical Research Council / United Kingdom
MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK075787 / DK / NIDDK NIH HHS / United States
MR/M004422/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK062370 / DK / NIDDK NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
MR/N01104X/1 / MRC_ / Medical Research Council / United Kingdom
MR/N015746/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK101855 / DK / NIDDK NIH HHS / United States
MR/S003746/1 / MRC_ / Medical Research Council / United Kingdom
G0401527 / MRC_ / Medical Research Council / United Kingdom
RG/15/12/31616 / BHF_ / British Heart Foundation / United Kingdom
G1000143 / MRC_ / Medical Research Council / United Kingdom
MR/L01632X/1 / MRC_ / Medical Research Council / United Kingdom
S10 OD023680 / OD / NIH HHS / United States
I01 CX000982 / CX / CSRD VA / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
U01 DK062370 / DK / NIDDK NIH HHS / United States
K12 HD043483 / HD / NICHD NIH HHS / United States
G0601966 / MRC_ / Medical Research Council / United Kingdom
14136 / CRUK_ / Cancer Research UK / United Kingdom
I01 BX003360 / BX / BLRD VA / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
WT_ / Wellcome Trust / United Kingdom

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