Rare coding variants in ten genes confer substantial risk for schizophrenia.

Nature
Authors
Keywords
Abstract

Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate ultra-rare coding variants (URVs) in 10 genes as conferring substantial risk for schizophrenia (odds ratios of 3-50, P 

Year of Publication
2022
Journal
Nature
Volume
604
Issue
7906
Pages
509-516
Date Published
2022 Apr
ISSN
1476-4687
DOI
10.1038/s41586-022-04556-w
PubMed ID
35396579
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