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Nat Commun DOI:10.1038/s41467-022-28983-5

Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task.

Publication TypeJournal Article
Year of Publication2022
AuthorsBloem, B, Huda, R, Amemori, K-I, Abate, AS, Krishna, G, Wilson, AL, Carter, CW, Sur, M, Graybiel, AM
JournalNat Commun
Volume13
Issue1
Pages1541
Date Published2022 Mar 22
ISSN2041-1723
KeywordsAnimals, Corpus Striatum, Mice, Neurons, Punishment, Reinforcement, Psychology, Reward
Abstract

Learning about positive and negative outcomes of actions is crucial for survival and underpinned by conserved circuits including the striatum. How associations between actions and outcomes are formed is not fully understood, particularly when the outcomes have mixed positive and negative features. We developed a novel foraging ('bandit') task requiring mice to maximize rewards while minimizing punishments. By 2-photon Ca imaging, we monitored activity of visually identified anterodorsal striatal striosomal and matrix neurons. We found that action-outcome associations for reward and punishment were encoded in parallel in partially overlapping populations. Single neurons could, for one action, encode outcomes of opposing valence. Striosome compartments consistently exhibited stronger representations of reinforcement outcomes than matrix, especially for high reward or punishment prediction errors. These findings demonstrate multiplexing of action-outcome contingencies by single identified striatal neurons and suggest that striosomal neurons are particularly important in action-outcome learning.

DOI10.1038/s41467-022-28983-5
Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/35318343?dopt=Abstract

Alternate JournalNat Commun
PubMed ID35318343
Grant ListEF1451125 / / National Science Foundation (NSF) /
20H05063 / / MEXT | Japan Society for the Promotion of Science (JSPS) /
R01 MH060379 / MH / NIMH NIH HHS / United States
R00 MH112855 / MH / NIMH NIH HHS / United States
18K19497 / / MEXT | Japan Society for the Promotion of Science (JSPS) /
20H03555 / / MEXT | Japan Society for the Promotion of Science (JSPS) /
306140 / / Simons Foundation /
R01 EY007023 / EY / NEI NIH HHS / United States
20H05469 / / MEXT | Japan Society for the Promotion of Science (JSPS) /
R01 EY028219 / EY / NEI NIH HHS / United States
U01 NS090473 / NS / NINDS NIH HHS / United States