Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential.
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Abstract | Salt-inducible kinases (SIKs) represent a subfamily of AMP-activated protein kinase (AMPK) family kinases. Initially named because SIK1 (the founding member of this kinase family) expression is regulated by dietary salt intake in the adrenal gland, it is now apparent that a major biological role of these kinases is to control gene expression in response to extracellular cues that increase intracellular levels of cAMP. Here, we review four physiologically relevant examples of how cAMP signaling impinges upon SIK cellular function. By focusing on examples of cAMP-mediated SIK regulation in gut myeloid cells, bone, liver, and skin, we highlight recent advances in G protein-coupled receptor (GPCR) signal transduction. New knowledge regarding the role of SIKs in GPCR signaling has led to therapeutic applications of novel small molecule SIK inhibitors. |
Year of Publication | 2018
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Journal | Trends Endocrinol Metab
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Volume | 29
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Issue | 10
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Pages | 723-735
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Date Published | 2018 10
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ISSN | 1879-3061
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DOI | 10.1016/j.tem.2018.08.004
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PubMed ID | 30150136
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PubMed Central ID | PMC6151151
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Grant list | U19 AI109725 / AI / NIAID NIH HHS / United States
R01 AR072304 / AR / NIAMS NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
R03 AR072150 / AR / NIAMS NIH HHS / United States
UM1 AI110498 / AI / NIAID NIH HHS / United States
P01 CA163222 / CA / NCI NIH HHS / United States
R01 CA222871 / CA / NCI NIH HHS / United States
R01 AR043369 / AR / NIAMS NIH HHS / United States
K08 AR067285 / AR / NIAMS NIH HHS / United States
R03 AR072903 / AR / NIAMS NIH HHS / United States
P30 AR066261 / AR / NIAMS NIH HHS / United States
P01 DK011794 / DK / NIDDK NIH HHS / United States
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