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STAR Protoc DOI:10.1016/j.xpro.2021.100766

Analytical protocol to identify local ancestry-associated molecular features in cancer.

Publication TypeJournal Article
Year of Publication2021
AuthorsCarrot-Zhang, J, Han, S, Zhou, W, Damrauer, JS, Kemal, A, Cherniack, AD, Beroukhim, R
Corporate AuthorsCancer Genome Atlas Analysis Network
JournalSTAR Protoc
Volume2
Issue4
Pages100766
Date Published2021 Dec 17
ISSN2666-1667
Abstract

People of different ancestries vary in cancer risk and outcome, and their molecular differences may indicate sources of these variations. Determining the "local" ancestry composition at each genetic locus across ancestry-admixed populations can suggest causal associations. We present a protocol to identify local ancestry and detect the associated molecular changes, using data from the Cancer Genome Atlas. This workflow can be applied to cancer cohorts with matched tumor and normal data from admixed patients to examine germline contributions to cancer. For complete details on the use and execution of this protocol, please refer to Carrot-Zhang et al. (2020).

DOI10.1016/j.xpro.2021.100766
Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/34585150?dopt=Abstract

Alternate JournalSTAR Protoc
PubMed ID34585150
PubMed Central IDPMC8456058