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Science DOI:10.1126/science.1193162

Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.

Publication TypeJournal Article
Year of Publication2010
AuthorsBartholomay, LC, Waterhouse, RM, Mayhew, GF, Campbell, CL, Michel, K, Zou, Z, Ramirez, JL, Das, S, Alvarez, K, Arensburger, P, Bryant, B, Chapman, SB, Dong, Y, Erickson, SM, Karunaratne, SHPParakr, Kokoza, V, Kodira, CD, Pignatelli, P, Shin, SWoon, Vanlandingham, DL, Atkinson, PW, Birren, B, Christophides, GK, Clem, RJ, Hemingway, J, Higgs, S, Megy, K, Ranson, H, Zdobnov, EM, Raikhel, AS, Christensen, BM, Dimopoulos, G, Muskavitch, MAT
JournalScience
Volume330
Issue6000
Pages88-90
Date Published2010 Oct 1
ISSN1095-9203
KeywordsAedes, Animals, Anopheles gambiae, Arboviruses, Bacteria, Biological Evolution, Culex, Ecosystem, Filarioidea, Gene Expression Profiling, Gene Expression Regulation, Genes, Insect, Host-Pathogen Interactions, Immunity, Innate, Insect Vectors, Oligonucleotide Array Sequence Analysis, Phylogeny, RNA Interference, Transcription, Genetic, West Nile virus
Abstract

The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.

DOI10.1126/science.1193162
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20929811?dopt=Abstract

Alternate JournalScience
PubMed ID20929811
PubMed Central IDPMC3104938
Grant ListF31 AI080161 / AI / NIAID NIH HHS / United States
F31 AI080161-01A1 / AI / NIAID NIH HHS / United States
F31 AI080161-01A1 / AI / NIAID NIH HHS / United States
HHSN266200400001C / AO / NIAID NIH HHS / United States
HHSN266200400001C / / PHS HHS / United States
HHSN266200400039C / AI / NIAID NIH HHS / United States
HHSN266200400039C / / PHS HHS / United States
P20 RR017686 / RR / NCRR NIH HHS / United States
P20 RR017686 / RR / NCRR NIH HHS / United States
P20 RR017686-01 / RR / NCRR NIH HHS / United States
R01 AI019769 / AI / NIAID NIH HHS / United States
R01 AI019769-26 / AI / NIAID NIH HHS / United States
R01 AI059492 / AI / NIAID NIH HHS / United States
R01 AI059492 / AI / NIAID NIH HHS / United States
R01 AI059492-05 / AI / NIAID NIH HHS / United States
R01 AI061576 / AI / NIAID NIH HHS / United States
R01 AI061576 / AI / NIAID NIH HHS / United States
R01 AI061576-08 / AI / NIAID NIH HHS / United States
R01 AI067698 / AI / NIAID NIH HHS / United States
R01 AI067698-05 / AI / NIAID NIH HHS / United States
R01 AI078997 / AI / NIAID NIH HHS / United States
R01 AI078997 / AI / NIAID NIH HHS / United States
R01 AI078997-02 / AI / NIAID NIH HHS / United States
R01 AI095842 / AI / NIAID NIH HHS / United States
R01 AI19769 / AI / NIAID NIH HHS / United States
R01 AI59492 / AI / NIAID NIH HHS / United States
R01 AI67698 / AI / NIAID NIH HHS / United States
R21 AI067642 / AI / NIAID NIH HHS / United States
R21 AI067642 / AI / NIAID NIH HHS / United States
R21 AI067642-01 / AI / NIAID NIH HHS / United States
T01CCT622892 / / PHS HHS / United States
T32 A107536 / / PHS HHS / United States
T32 AI007414 / AI / NIAID NIH HHS / United States
T32 AI007417 / AI / NIAID NIH HHS / United States
/ / Wellcome Trust / United Kingdom