Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations.

Nat Commun
Publication type
Journal Article
Authors
Keywords
Abstract

The human gut microbiota is increasingly recognized as an important factor in modulating innate and adaptive immunity through release of ligands and metabolites that translocate into circulation. Urbanizing African populations harbor large intestinal diversity due to a range of lifestyles, providing the necessary variation to gauge immunomodulatory factors. Here, we uncover a gradient of intestinal microbial compositions from rural through urban Tanzanian, towards European samples, manifested both in relative abundance and genomic variation observed in stool metagenomics. The rural population shows increased Bacteroidetes, led by Prevotella copri, but also presence of fungi. Measured ex vivo cytokine responses were significantly associated with 34 immunomodulatory microbes, which have a larger impact on circulating metabolites than non-significant microbes. Pathway effects on cytokines, notably TNF-α and IFN-γ, differential metabolome analysis and enzyme copy number enrichment converge on histidine and arginine metabolism as potential immunomodulatory pathways mediated by Bifidobacterium longum and Akkermansia muciniphila.

Year of Publication
2021
Journal
Nat Commun
Volume
12
Issue
1
Pages
4845
Date Published
2021 08 11
ISSN
2041-1723
DOI
10.1038/s41467-021-25213-2
PubMed ID
34381036
PubMed Central ID
PMC8357928
Links
Grant list
P30 DK043351 / DK / NIDDK NIH HHS / United States