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Nat Hum Behav DOI:10.1038/s41562-021-01182-w

Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits.

Publication TypeJournal Article
Year of Publication2021
AuthorsMerino, J, Dashti, HS, Sarnowski, C, Lane, JM, Todorov, PV, Udler, MS, Song, Y, Wang, H, Kim, J, Tucker, C, Campbell, J, Tanaka, T, Chu, AY, Tsai, L, Pers, TH, Chasman, DI, Rutter, MK, Dupuis, J, Florez, JC, Saxena, R
JournalNat Hum Behav
Date Published2021 Aug 23
ISSN2397-3374
Abstract

Dietary intake is a major contributor to the global obesity epidemic and represents a complex behavioural phenotype that is partially affected by innate biological differences. Here, we present a multivariate genome-wide association analysis of overall variation in dietary intake to account for the correlation between dietary carbohydrate, fat and protein in 282,271 participants of European ancestry from the UK Biobank (n = 191,157) and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (n = 91,114), and identify 26 distinct genome-wide significant loci. Dietary intake signals map exclusively to specific brain regions and are enriched for genes expressed in specialized subtypes of GABAergic, dopaminergic and glutamatergic neurons. We identified two main clusters of genetic variants for overall variation in dietary intake that were differently associated with obesity and coronary artery disease. These results enhance the biological understanding of interindividual differences in dietary intake by highlighting neural mechanisms, supporting functional follow-up experiments and possibly providing new avenues for the prevention and treatment of prevalent complex metabolic diseases.

DOI10.1038/s41562-021-01182-w
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/34426670?dopt=Abstract

Alternate JournalNat Hum Behav
PubMed ID34426670
Grant ListDK040561 / / U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) /
DK105072 / / U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) /
DK078616 / / U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) /
DK078616 / / U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) /
DK110550 / / U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) /
DK107859 / / U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) /
DK105072 / / U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) /
HL007901 / / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) /
NNF16OC0021496 / / Novo Nordisk /
NNF16OC0021496 / / Novo Nordisk /
1-18-INI-14 / / American Diabetes Association (ADA) /