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Cell Rep DOI:10.1016/j.celrep.2021.109443

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization.

Publication TypeJournal Article
Year of Publication2021
AuthorsDai, C, Rennhack, JP, Arnoff, TE, Thaker, M, Younger, ST, Doench, JG, Huang, AYue, Yang, A, Aguirre, AJ, Wang, B, Mun, E, O'Connell, JT, Huang, Y, Labella, K, Talamas, JA, Li, J, Ilic, N, Hwang, J, Hong, AL, Giacomelli, AO, Gjoerup, O, Root, DE, Hahn, WC
JournalCell Rep
Date Published2021 Jul 27

Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor prognosis. In this study, we use isogenic cancer cell lines to identify SMAD4 regulated genes that contribute to the development of metastatic colonization. We perform an in vivo screen identifying FOSL1 as both a SMAD4 target and sufficient to drive colonization to the lung. The targeting of these genes early in treatment may provide a therapeutic benefit.


Alternate JournalCell Rep
PubMed ID34320363