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2016
Discovery of a proteinaceous cellular receptor for a norovirus.Orchard, RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S., Pruett-Miller SM, Nelson CA, Fremont DH, and Virgin HW Science (New York, N.Y.), 2016/08/26, Volume 353, Issue 6302, p.933-6, (2016) Read More / View Supplemental Materials
Abstract
Impaired Autophagy in Macrophages Promotes Inflammatory Eye Disease.Santeford, A., Wiley LA, Park S., Bamba S., Nakamura R., Gdoura A., Ferguson TA, Rao PK, Guan JL, Saitoh T., Akira S., Xavier R., Virgin HW, and Apte RS Autophagy, 2016/07/27, (2016) Read More / View Supplemental Materials
Abstract
Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.Reese, TA, Bi K., Kambal A., Filali-Mouhim A., Beura LK, Bürger MC, Pulendran B., Sekaly RP, Jameson SC, Masopust D., Haining WN, and Virgin HW Cell host & microbe, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.Doench, JG, Fusi N., Sullender M., Hegde M., Vaimberg EW, Donovan KF, Smith I., Tothova Z., Wilen C., Orchard R., Virgin HW, Listgarten J., and Root DE Nature biotechnology, 2016/01/18, (2016) Read More / View Supplemental Materials
Abstract
2015
A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.Selleck, EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B., Virgin HW, and Sibley LD mBio, 2015/09/08, Volume 6, Issue 5, (2015) Read More / View Supplemental Materials
Abstract
Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.Anahtar, MN, Byrne EH, Doherty KE, Bowman BA, Yamamoto HS, Soumillon M., Padavattan N., Ismail N., Moodley A., Sabatini ME, Ghebremichael MS, Nusbaum C., Huttenhower C., Virgin HW, Ndung'u T., Dong KL, Walker BD, Fichorova RN, and Kwon DS Immunity, 2015/05/19, Volume 42, Issue 5, p.965-76, (2015) Read More / View Supplemental Materials
Abstract
Disease-specific alterations in the enteric virome in inflammatory bowel disease.Norman, JM, Handley SA, Baldridge MT, Droit L., Liu CY, Keller BC, Kambal A., Monaco CL, Zhao G., Fleshner P., Stappenbeck TS, McGovern DP, Keshavarzian A., Mutlu EA, Sauk J., Gevers D., Xavier RJ, Wang D., Parkes M., and Virgin HW Cell, 2015/01/29, Volume 160, Issue 3, p.447-60, (2015) Read More / View Supplemental Materials
Abstract
2014
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.Lassen, KG, Kuballa P., Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L., Horn H., Mercer J., Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly M. J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/05/12, (2014) Read More / View Supplemental Materials
Abstract
2013
Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.Conway, KL, Kuballa P., Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M., Aldrich LN, Villablanca EJ, Peloquin JM, Goel G., Lee IA, Mizoguchi E., Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, et al. Gastroenterology, 2013/08/21, (2013) Read More / View Supplemental Materials
Abstract
ATG5 regulates plasma cell differentiation.Conway, KL, Kuballa P., Khor B., Zhang M., Shi HN, Virgin HW, and Xavier RJ Autophagy, 2013/01/17, Volume 9, Issue 4, (2013) Read More / View Supplemental Materials
Abstract
  • Showing 1-10 of 10 Results