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  • Showing 1-14 of 14 Results
2016
Characterizing genomic alterations in cancer by complementary functional associations.Kim, JW, Botvinnik OB, Abudayyeh O., Birger C., Rosenbluh J., Shrestha Y., Abazeed ME, Hammerman PS, Dicara D., Konieczkowski DJ, Johannessen CM, Liberzon A., Alizad-Rahvar AR, Alexe G., Aguirre A., Ghandi M., Greulich H., Vazquez F., Weir BA, Van Allen EM, et al. Nature biotechnology, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Kryukov, GV, Wilson FH, Ruth JR, Paulk J., Tsherniak A., Marlow SE, Vazquez F., Weir BA, Fitzgerald ME, Tanaka M., Bielski CM, Scott JM, Dennis C., Cowley GS, Boehm JS, Root DE, Golub T. R., Clish CB, Bradner JE, Hahn WC, et al. Science (New York, N.Y.), 2016/02/11, (2016) Read More / View Supplemental Materials
Abstract
Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy.Gannon, HS, Kaplan N., Tsherniak A., Vazquez F., Weir BA, Hahn WC, and Meyerson M. Molecular cancer research : MCR, 2016/02/01, Volume 14, Issue 2, p.207-15, (2016) Read More / View Supplemental Materials
Abstract
2015
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.Kim, KH, Kim W., Howard TP, Vazquez F., Tsherniak A., Wu JN, Wang W., Haswell JR, Walensky LD, Hahn WC, Orkin SH, and Roberts CW Nature medicine, 2015/11/09, (2015) Read More / View Supplemental Materials
Abstract
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis.Pomerantz, MM, Li F., Takeda DY, Lenci R., Chonkar A., Chabot M., Cejas P., Vazquez F., Cook J., Shivdasani RA, Bowden M., Lis R., Hahn WC, Kantoff PW, Brown M., Loda M., Long HW, and Freedman ML Nature genetics, 2015/11/01, Volume 47, Issue 11, p.1346-51, (2015) Read More / View Supplemental Materials
Abstract
Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Kennedy, AL, Vallurupalli M., Chen L., Crompton B., Cowley G., Vazquez F., Weir BA, Tsherniak A., Parasuraman S., Kim S., Alexe G., and Stegmaier K. Oncotarget, 2015/10/06, Volume 6, Issue 30, p.30178-93, (2015) Read More / View Supplemental Materials
Abstract
2014
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.Lee, Y., Dominy JE, Choi YJ, Jurczak M., Tolliday N., Camporez JP, Chim H., Lim JH, Ruan HB, Yang X., Vazquez F., Sicinski P., Shulman GI, and Puigserver P. Nature, 2014/05/25, (2014) Read More / View Supplemental Materials
Abstract
ARID1B is a specific vulnerability in ARID1A-mutant cancers.Helming, KC, Wang X., Wilson BG, Vazquez F., Haswell JR, Manchester HE, Kim Y., Kryukov GV, Ghandi M., Aguirre AJ, Jagani Z., Wang Z., Garraway LA, Hahn WC, and Roberts CW Nature medicine, 2014/03/01, Volume 20, Issue 3, p.251-4, (2014) Read More / View Supplemental Materials
Abstract
Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation.Wilson, BG, Helming KC, Wang X., Kim Y., Vazquez F., Jagani Z., Hahn WC, and Roberts CW Molecular and cellular biology, 2014/03/01, Volume 34, Issue 6, p.1136-44, (2014) Read More / View Supplemental Materials
Abstract
In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene.Dunn, GP, Cheung HW, Karst AM, Boehm JS, Weir BA, Berlin AM, Zou L., Getz G., Liu JF, Vazquez F., Root DE, Beroukhim R., Drapkin R., and Hahn WC Proceedings of the National Academy of Sciences of the United States of America, 2014/01/21, Volume 111, Issue 3, p.1102-7, (2014) Read More / View Supplemental Materials
Abstract
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.Cowley, GS, Weir BA, Vazquez F., Tamayo P., Scott JA, Rusin S., East-Seletsky A., Ali LD, Gerath WF, Pantel SE, Lizotte PH, Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green TM, et al. Scientific data, 2014/01/01, Volume 1, p.140035, (2014) Read More / View Supplemental Materials
Abstract
2013
Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.Hagerstrand, D., Tong A., Schumacher SE, Ilic N., Shen RR, Cheung HW, Vazquez F., Shrestha Y., Kim SY, Rosenbluh J., Schinzel AC, Barbie DA, Mermel CH, Weir BA, Garraway LA, Tamayo P., Mesirov J. P., Beroukhim R., and Hahn WC Cancer discovery, 2013/06/13, (2013) Read More / View Supplemental Materials
Abstract
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.Vazquez, F., Lim JH, Chim H., Bhalla K., Girnun G., Pierce K., Clish CB, Granter SR, Widlund HR, Spiegelman BM, and Puigserver P. Cancer cell, 2013/03/18, Volume 23, Issue 3, p.287-301, (2013) Read More / View Supplemental Materials
Abstract
2012
β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis.Rosenbluh, J., Nijhawan D., Cox AG, Li X., Schafer EJ, Zack TI, Wang X., Tsherniak A., Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F., Cowley GS, Root DE, Mesirov J. P., Beroukhim R., and Hahn WC Cell, 2012/12/21, Volume 151, Issue 7, p.1457-73, (2012) Read More / View Supplemental Materials
Abstract
  • Showing 1-14 of 14 Results