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2015
Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.Graham, DB, Becker CE, Doan A., Goel G., Villablanca EJ, Knights D., Mok A., Ng AC, Doench JG, Root DE, Clish CB, and Xavier RJ Nature communications, 2015/07/21, Volume 6, p.7838, (2015) Read More / View Supplemental Materials
Abstract
Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.Egan, ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C., Tani Y., Takahashi J., Watanabe S., Goldberg J., Paul AS, Brugnara C., Root DE, Wiegand RC, Doench JG, and Duraisingh MT Science (New York, N.Y.), 2015/05/08, Volume 348, Issue 6235, p.711-4, (2015) Read More / View Supplemental Materials
Abstract
Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.Rotem, A., Janzer A., Izar B., Ji Z., Doench JG, Garraway LA, and Struhl K. Proceedings of the National Academy of Sciences of the United States of America, 2015/04/20, (2015) Read More / View Supplemental Materials
Abstract
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.Chen, CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N., Eng R., Doench JG, Xu H., Chu SH, Qi J., Wang X., Delaney C., Bernt KM, Root DE, Hahn WC, Bradner JE, and Armstrong SA Nature medicine, 2015/03/30, (2015) Read More / View Supplemental Materials
Abstract
Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects.Singh, S., Wu X., Ljosa V., Bray MA, Piccioni F., Root DE, Doench JG, Boehm JS, and Carpenter AE PloS one, 2015/01/01, Volume 10, Issue 7, p.e0131370, (2015) Read More / View Supplemental Materials
Abstract
2014
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.Doench, JG, Hartenian E., Graham DB, Tothova Z., Hegde M., Smith I., Sullender M., Ebert BL, Xavier RJ, and Root DE Nature biotechnology, 2014/09/03, (2014) Read More / View Supplemental Materials
Abstract
Genome-scale CRISPR-Cas9 knockout screening in human cells.Shalem, O., Sanjana NE, Hartenian E., Shi X., Scott DA, Mikkelsen TS, Heckl D., Ebert BL, Root DE, Doench JG, and Zhang F. Science (New York, N.Y.), 2014/01/03, Volume 343, Issue 6166, p.84-7, (2014) Read More / View Supplemental Materials
Abstract
2013
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.Chapuy, B., McKeown MR, Lin CY, Monti S., Roemer MG, Qi J., Rahl PB, Sun HH, Yeda KT, Doench JG, Reichert E., Kung AL, Rodig SJ, Young RA, Shipp M. A., and Bradner JE Cancer cell, 2013/12/09, Volume 24, Issue 6, p.777-90, (2013) Read More / View Supplemental Materials
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2012
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.Lee, MN, Roy M., Ong SE, Mertins P., Villani AC, Li W., Dotiwala F., Sen J., Doench JG, Orzalli MH, Kramnik I., Knipe DM, Lieberman J., Carr SA, and Hacohen N. Nature immunology, 2012/12/23, Volume 14, Issue 2, p.179-85, (2012) Read More / View Supplemental Materials
Abstract
Reduced Expression of Ribosomal Proteins Relieves MicroRNA-Mediated Repression.Janas, MM, Wang E., Love T., Harris AS, Stevenson K., Semmelmann K., Shaffer JM, Chen PH, Doench JG, Yerramilli SV, Neuberg DS, Iliopoulos D., Housman DE, Burge CB, and Novina CD Molecular cell, 2012/04/27, Volume 46, Issue 2, p.171-86, (2012) Read More / View Supplemental Materials
Abstract
  • Showing 1-10 of 10 Results