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2013
Synthesis of stereochemically and skeletally diverse fused ring systems from functionalized C-glycosides.Gerard, B., Lee MD 4th, Dandapani S., Duvall JR, Fitzgerald ME, Kesavan S., Lowe JT, Marié JC, Pandya BA, Suh BC, O'Shea MW, Dombrowski M., Hamann D., Lemercier B., Murillo T., Akella LB, Foley MA, and Marcaurelle LA The Journal of organic chemistry, 2013/06/07, Volume 78, Issue 11, p.5160-71, (2013) Read More / View Supplemental Materials
Abstract
An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries.Mulrooney, CA, Lahr DL, Quintin MJ, Youngsaye W., Moccia D., Asiedu JK, Mulligan EL, Akella LB, Marcaurelle LA, Montgomery P., Bittker JA, Clemons PA, Brudz S., Dandapani S., Duvall JR, Tolliday NJ, and De Souza A. Journal of computer-aided molecular design, 2013/04/13, (2013) Read More / View Supplemental Materials
Abstract
2012
Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library.Gerard, B., O'Shea MW, Donckele E., Kesavan S., Akella LB, Xu H., Jacobsen EN, and Marcaurelle LA ACS combinatorial science, 2012/10/22, (2012) Read More / View Supplemental Materials
Abstract
Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries.Lowe, JT, Lee MD 4th, Akella LB, Davoine E., Donckele EJ, Durak L., Duvall JR, Gerard B., Holson EB, Joliton A., Kesavan S., Lemercier BC, Liu H., Marié JC, Mulrooney CA, Muncipinto G., Welzel-O'Shea M., Panko LM, Rowley A., Suh BC, et al. The Journal of organic chemistry, 2012/08/10, (2012) Read More / View Supplemental Materials
Abstract
Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization.Fitzgerald, ME, Mulrooney CA, Duvall JR, Wei J., Suh BC, Akella LB, Vrcic A., and Marcaurelle LA ACS combinatorial science, 2012/02/13, Volume 14, Issue 2, p.89-96, (2012) Read More / View Supplemental Materials
Abstract
Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.Heidebrecht RW, Jr, Mulrooney C., Austin CP, Barker RH Jr, Beaudoin JA, Cheng KC, Comer E., Dandapani S., Dick J., Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M., Guha R., Hinkson P., Kramer M., Lukens AK, Masi D., Marcaurelle LA, et al. ACS medicinal chemistry letters, 2012/02/09, Volume 3, Issue 2, p.112-117, (2012) Read More / View Supplemental Materials
Abstract
Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet CellsFaloon, PW, Chou DHC, Forbeck EM, Walpita D., Morgan B., Buhrlage S., Ting A., Perez J., MacPherson LJ, Duvall JR, Dandapani S., Marcaurelle LA, Munoz B., Palmer M., Foley M., Wagner B., and Schreiber SL, 2012/01/09, (2012) Read More / View Supplemental Materials
Abstract
Application of natural product-inspired diversity-oriented synthesis to drug discovery.Marcaurelle, LA, and Johannes CW Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 2012/01/05, Volume 66, p.187, 189-216, (2012) Read More / View Supplemental Materials
Abstract
2011
Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.Dandapani, S., Lowe JT, Comer E., and Marcaurelle LA The Journal of organic chemistry, 2011/10/07, Volume 76, Issue 19, p.8042-8, (2011) Read More / View Supplemental Materials
Abstract
Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis.Chou, DH, Duvall JR, Gerard B., Liu H., Pandya BA, Suh BC, Forbeck EM, Faloon P., Wagner BK, and Marcaurelle LA ACS medicinal chemistry letters, 2011/09/08, Volume 2, Issue 9, p.698-702, (2011) Read More / View Supplemental Materials
Abstract
Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions.Pandya, BA, Dandapani S., Duvall JR, Rowley A., Mulrooney CA, Ryba T., Dombrowski M., Harton M., Young DW, and Marcaurelle LA Tetrahedron, 2011/08/26, Volume 67, Issue 34, p.6131-6137, (2011) Read More / View Supplemental Materials
Abstract
Application of a sparse matrix design strategy to the synthesis of dos libraries.Akella, LB, and Marcaurelle LA ACS combinatorial science, 2011/07/11, Volume 13, Issue 4, p.357-64, (2011) Read More / View Supplemental Materials
Abstract
Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification.Gerard, B., Duvall JR, Lowe JT, Murillo T., Wei J., Akella LB, and Marcaurelle LA ACS combinatorial science, 2011/07/11, Volume 13, Issue 4, p.365-74, (2011) Read More / View Supplemental Materials
Abstract
Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.Comer, E., Liu H., Joliton A., Clabaut A., Johnson C., Akella LB, and Marcaurelle LA Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6751-6, (2011) Read More / View Supplemental Materials
Abstract
Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold.Gerard, B., Marié JC, Pandya BA, Lee MD 4th, Liu H., and Marcaurelle LA The Journal of organic chemistry, 2011/03/18, Volume 76, Issue 6, p.1898-901, (2011) Read More / View Supplemental Materials
Abstract
2010
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.Marcaurelle, LA, Comer E., Dandapani S., Duvall JR, Gerard B., Kesavan S., Lee MD 4th, Liu H., Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A., Ryba TD, Suh BC, Wei J., Young DW, Akella LB, Ross NT, Zhang YL, et al. Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.16962-76, (2010) Read More / View Supplemental Materials
Abstract
Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.Dandapani, S., and Marcaurelle LA Nature chemical biology, 2010/12/01, Volume 6, Issue 12, p.861-3, (2010) Read More / View Supplemental Materials
Abstract
Current strategies for diversity-oriented synthesis.Dandapani, S., and Marcaurelle LA Current opinion in chemical biology, 2010/06/01, Volume 14, Issue 3, p.362-70, (2010) Read More / View Supplemental Materials
Abstract
2009
Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings.Kelly, AR, Wei J., Kesavan S., Marié JC, Windmon N., Young DW, and Marcaurelle LA Organic letters, 2009/06/04, Volume 11, Issue 11, p.2257-60, (2009) Read More / View Supplemental Materials
Abstract
Identifying the proteins to which small-molecule probes and drugs bind in cells.Ong, SE, Schenone M., Margolin AA, Li X., Do K., Doud MK, Mani D. R., Kuai L., Wang X., Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub T. R., Gould RJ, Schreiber SL, and Carr SA Proceedings of the National Academy of Sciences of the United States of America, 2009/03/24, Volume 106, Issue 12, p.4617-22, (2009) Read More / View Supplemental Materials
Abstract
1969
Large scale preparation of silicon-functionalized SynPhase Polystyrene lanterns for solid-phase synthesis.Ryba, TD, Depew KM, and Marcaurelle LA Journal of combinatorial chemistry, 1969/12/31, Volume 11, Issue 1, p.110-6, (1969) Read More / View Supplemental Materials
Abstract
  • Showing 1-21 of 21 Results