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2015
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.Parnas, O., Jovanovic M., Eisenhaure TM, Herbst RH, Dixit A., Ye CJ, Przybylski D., Platt RJ, Tirosh I., Sanjana NE, Shalem O., Satija R., Raychowdhury R., Mertins P., Carr SA, Zhang F., Hacohen N., and Regev A. Cell, 2015/07/15, (2015) Read More / View Supplemental Materials
Abstract
CRISPR-Cas9: Prospects and Challenges.Zhang, F. Human gene therapy, 2015/07/01, Volume 26, Issue 7, p.409-10, (2015) Read More / View Supplemental Materials
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.Ramanan, V., Shlomai A., Cox DB, Schwartz RE, Michailidis E., Bhatta A., Scott DA, Zhang F., Rice CM, and Bhatia SN Scientific reports, 2015/06/02, Volume 5, p.10833, (2015) Read More / View Supplemental Materials
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Brains, Genes, and Primates.Belmonte, JC, Callaway EM, Churchland P., Caddick SJ, Feng G., Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S., Moutri AR, Movshon JA, Okano H., Reynolds JH, Ringach D., Sejnowski TJ, Silva AC, Strick PL, Wu J., et al. Neuron, 2015/05/06, Volume 86, Issue 3, p.617-631, (2015) Read More / View Supplemental Materials
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CRISPR germline engineering--the community speaks.Bosley, KS, Botchan M., Bredenoord AL, Carroll D., Charo RA, Charpentier E., Cohen R., Corn J., Doudna J., Feng G., Greely HT, Isasi R., Ji W., Kim JS, Knoppers B., Lanphier E., Li J., Lovell-Badge R., Martin GS, Moreno J., et al. Nature biotechnology, 2015/05/01, Volume 33, Issue 5, p.478-86, (2015) Read More / View Supplemental Materials
Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.Van Allen, EM, Lui VW, Egloff AM, Goetz EM, Li H., Johnson JT, Duvvuri U., Bauman JE, Stransky N., Zeng Y., Gilbert BR, Pendleton KP, Wang L., Chiosea S., Sougnez C., Wagle N., Zhang F., Du Y., Close D., Johnston PA, et al. JAMA oncology, 2015/05/01, Volume 1, Issue 2, p.238-44, (2015) Read More / View Supplemental Materials
Abstract
High-throughput functional genomics using CRISPR-Cas9.Shalem, O., Sanjana NE, and Zhang F. Nature reviews. Genetics, 2015/05/01, Volume 16, Issue 5, p.299-311, (2015) Read More / View Supplemental Materials
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In vivo genome editing using Staphylococcus aureus Cas9.Ran, FA, Cong L., Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B., Shalem O., Wu X., Makarova KS, Koonin EV, Sharp PA, and Zhang F. Nature, 2015/04/09, Volume 520, Issue 7546, p.186-91, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis.Chen, S., Sanjana NE, Zheng K., Shalem O., Lee K., Shi X., Scott DA, Song J., Pan JQ, Weissleder R., Lee H., Zhang F., and Sharp PA Cell, 2015/03/12, Volume 160, Issue 6, p.1246-60, (2015) Read More / View Supplemental Materials
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Therapeutic genome editing: prospects and challenges.Cox, DB, Platt RJ, and Zhang F. Nature medicine, 2015/02/05, Volume 21, Issue 2, p.121-131, (2015) Read More / View Supplemental Materials
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Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.Liu, H., Irwanto A., Fu X., Yu G., Yu Y., Sun Y., Wang C., Wang Z., Okada Y., Low H., Li Y., Liany H., Chen M., Bao F., Li J., You J., Zhang Q., Liu J., Chu T., Andiappan AK, et al. Nature genetics, 2015/02/02, (2015) Read More / View Supplemental Materials
Abstract
A split-Cas9 architecture for inducible genome editing and transcription modulation.Zetsche, B., Volz SE, and Zhang F. Nature biotechnology, 2015/02/02, Volume 33, Issue 2, p.139-142, (2015) Read More / View Supplemental Materials
Genome Engineering Using CRISPR-Cas9 System.Cong, L., and Zhang F. Methods in molecular biology (Clifton, N.J.), 2015/01/01, Volume 1239, p.197-217, (2015) Read More / View Supplemental Materials
Abstract
2014
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.Konermann, S., Brigham MD, Trevino AE, Joung J., Abudayyeh OO, Barcena C., Hsu PD, Habib N., Gootenberg JS, Nishimasu H., Nureki O., and Zhang F. Nature, 2014/12/10, (2014) Read More / View Supplemental Materials
Abstract
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.Swiech, L., Heidenreich M., Banerjee A., Habib N., Li Y., Trombetta J., Sur M., and Zhang F. Nature biotechnology, 2014/10/19, (2014) Read More / View Supplemental Materials
Abstract
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.Platt, RJ, Chen S., Zhou Y., Yim MJ, Swiech L., Kempton HR, Dahlman JE, Parnas O., Eisenhaure TM, Jovanovic M., Graham DB, Jhunjhunwala S., Heidenreich M., Xavier RJ, Langer R., Anderson DG, Hacohen N., Regev A., Feng G., Sharp PA, et al. Cell, 2014/09/24, (2014) Read More / View Supplemental Materials
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Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum.Wagner, JC, Platt RJ, Goldfless SJ, Zhang F., and Niles JC Nature methods, 2014/08/10, (2014) Read More / View Supplemental Materials
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CRISPR-mediated direct mutation of cancer genes in the mouse liver.Xue, W., Chen S., Yin H., Tammela T., Papagiannakopoulos T., Joshi NS, Cai W., Yang G., Bronson R., Crowley DG, Zhang F., Anderson DG, Sharp PA, and Jacks T. Nature, 2014/08/06, (2014) Read More / View Supplemental Materials
Abstract
Improved vectors and genome-wide libraries for CRISPR screening.Sanjana, NE, Shalem O., and Zhang F. Nature methods, 2014/07/30, Volume 11, Issue 8, p.783-4, (2014) Read More / View Supplemental Materials
Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5' Sites.Schwartz, S., Mumbach MR, Jovanovic M., Wang T., Maciag K., Bushkin GG, Mertins P., Ter-Ovanesyan D., Habib N., Cacchiarelli D., Sanjana NE, Freinkman E., Pacold ME, Satija R., Mikkelsen TS, Hacohen N., Zhang F., Carr SA, Lander E. S., and Regev A. Cell reports, 2014/06/25, (2014) Read More / View Supplemental Materials
Abstract
Development and Applications of CRISPR-Cas9 for Genome Engineering.Hsu, PD, Lander E. S., and Zhang F. Cell, 2014/06/05, Volume 157, Issue 6, p.1262-1278, (2014) Read More / View Supplemental Materials
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Global microRNA depletion suppresses tumor angiogenesis.Chen, S., Xue Y., Wu X., Le C., Bhutkar A., Bell EL, Zhang F., Langer R., and Sharp PA Genes & development, 2014/05/15, Volume 28, Issue 10, p.1054-67, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.Wu, X., Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S., Chen S., Jaenisch R., Zhang F., and Sharp PA Nature biotechnology, 2014/04/20, (2014) Read More / View Supplemental Materials
Abstract
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee, MN, Ye C., Villani AC, Raj T., Li W., Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K., Ward LD, Raddassi K., McCabe C., Lee MH, Frohlich IY, Hafler DA, Kellis M., Raychaudhuri S., Zhang F., Stranger BE, et al. Science (New York, N.Y.), 2014/03/07, Volume 343, Issue 6175, p.1246980, (2014) Read More / View Supplemental Materials
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Crystal structure of cas9 in complex with guide RNA and target DNA.Nishimasu, H., Ran FA, Hsu PD, Konermann S., Shehata SI, Dohmae N., Ishitani R., Zhang F., and Nureki O. Cell, 2014/02/27, Volume 156, Issue 5, p.935-49, (2014) Read More / View Supplemental Materials
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Genome-scale CRISPR-Cas9 knockout screening in human cells.Shalem, O., Sanjana NE, Hartenian E., Shi X., Scott DA, Mikkelsen TS, Heckl D., Ebert BL, Root DE, Doench JG, and Zhang F. Science (New York, N.Y.), 2014/01/03, Volume 343, Issue 6166, p.84-7, (2014) Read More / View Supplemental Materials
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Genome editing using cas9 nickases.Trevino, AE, and Zhang F. Methods in enzymology, 2014/01/01, Volume 546, p.161-74, (2014) Read More / View Supplemental Materials
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RNA-Guided Genome Editing of Mammalian Cells.Pyzocha, NK, Ran FA, Hsu PD, and Zhang F. Methods in molecular biology (Clifton, N.J.), 2014/01/01, Volume 1114, p.269-77, (2014) Read More / View Supplemental Materials
Abstract
2013
Genome engineering using the CRISPR-Cas9 system.Ran, FA, Hsu PD, Wright J., Agarwala V., Scott DA, and Zhang F. Nature protocols, 2013/11/01, Volume 8, Issue 11, p.2281-308, (2013) Read More / View Supplemental Materials
Abstract
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity.Ran, FA, Hsu PD, Lin CY, Gootenberg JS, Konermann S., Trevino AE, Scott DA, Inoue A., Matoba S., Zhang Y., and Zhang F. Cell, 2013/09/12, Volume 154, Issue 6, p.1380-9, (2013) Read More / View Supplemental Materials
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Optical control of mammalian endogenous transcription and epigenetic states.Konermann, S., Brigham MD, Trevino AE, Hsu PD, Heidenreich M., Cong L., Platt RJ, Scott DA, Church GM, and Zhang F. Nature, 2013/08/22, Volume 500, Issue 7463, p.472-6, (2013) Read More / View Supplemental Materials
Abstract
DNA targeting specificity of RNA-guided Cas9 nucleases.Hsu, PD, Scott DA, Weinstein JA, Ran FA, Konermann S., Agarwala V., Li Y., Fine EJ, Wu X., Shalem O., Cradick TJ, Marraffini LA, Bao G., and Zhang F. Nature biotechnology, 2013/07/21, (2013) Read More / View Supplemental Materials
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Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.Bikard, D., Jiang W., Samai P., Hochschild A., Zhang F., and Marraffini LA Nucleic acids research, 2013/06/12, (2013) Read More / View Supplemental Materials
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Multiplex Genome Engineering Using CRISPR/Cas Systems.Cong, L., Ran FA, Cox D., Lin S., Barretto R., Habib N., Hsu PD, Wu X., Jiang W., Marraffini LA, and Zhang F. Science (New York, N.Y.), 2013/01/03, (2013) Read More / View Supplemental Materials
Abstract
2012
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains.Cong, L., Zhou R., Kuo YC, Cunniff M., and Zhang F. Nature communications, 2012/07/24, Volume 3, p.968, (2012) Read More / View Supplemental Materials
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Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers.Briggs, AW, Rios X., Chari R., Yang L., Zhang F., Mali P., and Church GM Nucleic acids research, 2012/06/26, (2012) Read More / View Supplemental Materials
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A transcription activator-like effector toolbox for genome engineering.Sanjana, NE, Cong L., Zhou Y., Cunniff MM, Feng G., and Zhang F. Nature protocols, 2012/01/05, Volume 7, Issue 1, p.171-92, (2012) Read More / View Supplemental Materials
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2011
The microbial opsin family of optogenetic tools.Zhang, F., Vierock J., Yizhar O., Fenno LE, Tsunoda S., Kianianmomeni A., Prigge M., Berndt A., Cushman J., Polle J., Magnuson J., Hegemann P., and Deisseroth K. Cell, 2011/12/23, Volume 147, Issue 7, p.1446-57, (2011) Read More / View Supplemental Materials
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  • Showing 1-38 of 38 Results