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  • Showing 1-25 of 25 Results
2014
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee, MN, Ye C., Villani AC, Raj T., Li W., Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K., Ward LD, Raddassi K., McCabe C., Lee MH, Frohlich IY, Hafler DA, Kellis M., Raychaudhuri S., Zhang F., Stranger BE, et al. Science (New York, N.Y.), 2014/03/07, Volume 343, Issue 6175, p.1246980, (2014) Read More / View Supplemental Materials
Abstract
Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease.Bennett, DA, Yu L., and De Jager PL Biochemical pharmacology, 2014/02/06, (2014) Read More / View Supplemental Materials
Abstract
A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.Damotte, V., Guillot-Noel L., Patsopoulos NA, Madireddy L., El Behi M., International Multiple Sclerosis Genetics Consortium, Ban M., Baranzini S., Barcellos L., Beecham G., Beecham A., Bernardinelli L., Booth D., Bos S., Buck D., Bush W., Comabella M., Compston A., Cotsapas C., Cournu-Rebeix I., et al. Genes and immunity, 2014/01/16, (2014) Read More / View Supplemental Materials
Abstract
Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene.Okada, Y., Diogo D., Greenberg JD, Mouassess F., Achkar WA, Fulton RS, Denny JC, Gupta N., Mirel D., Gabriel S., Li G., Kremer JM, Pappas DA, Carroll RJ, Eyler AE, Trynka G., Stahl EA, Cui J., Saxena R., Coenen MJ, et al. PloS one, 2014/01/01, Volume 9, Issue 2, p.e87645, (2014) Read More / View Supplemental Materials
Abstract
2013
Genetics of rheumatoid arthritis contributes to biology and drug discovery.Okada, Y., Wu D., Trynka G., Raj T., Terao C., Ikari K., Kochi Y., Ohmura K., Suzuki A., Yoshida S., Graham RR, Manoharan A., Ortmann W., Bhangale T., Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
Abstract
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.Ottoboni, L., Frohlich IY, Lee M., Healy BC, Keenan BT, Xia Z., Chitnis T., Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, and De Jager PL Neurology, 2013/11/26, Volume 81, Issue 22, p.1891-9, (2013) Read More / View Supplemental Materials
Abstract
Modeling disease severity in multiple sclerosis using electronic health records.Xia, Z., Secor E., Chibnik LB, Bove RM, Cheng S., Chitnis T., Cagan A., Gainer VS, Chen PJ, Liao KP, Shaw SY, Ananthakrishnan AN, Szolovits P., Weiner HL, Karlson EW, Murphy SN, Savova GK, Cai T., Churchill SE, Plenge RM, et al. PloS one, 2013/11/11, Volume 8, Issue 11, p.e78927, (2013) Read More / View Supplemental Materials
Abstract
Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects.Patsopoulos, NA, Barcellos LF, Hintzen RQ, Schaefer C., van Duijn CM, Noble JA, Raj T., IMSGC, ANZgene, Gourraud PA, Stranger BE, Oksenberg J., Olsson T., Taylor BV, Sawcer S., Hafler DA, Carrington M., De Jager PL, and de Bakker PI PLoS genetics, 2013/11/01, Volume 9, Issue 11, p.e1003926, (2013) Read More / View Supplemental Materials
Abstract
Charting a dynamic DNA methylation landscape of the human genome.Ziller, MJ, Gu H., Müller F., Donaghey J., Tsai LT, Kohlbacher O., De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A., and Meissner A. Nature, 2013/08/22, Volume 500, Issue 7463, p.477-81, (2013) Read More / View Supplemental Materials
Abstract
Genetic risk variants in African Americans with multiple sclerosis.Isobe, N., Gourraud PA, Harbo HF, Caillier SJ, Santaniello A., Khankhanian P., Maiers M., Spellman S., Cereb N., Yang S., Pando MJ, Piccio L., Cross AH, De Jager PL, Cree BA, Hauser SL, and Oksenberg JR Neurology, 2013/07/16, Volume 81, Issue 3, p.219-227, (2013) Read More / View Supplemental Materials
Abstract
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.Bradshaw, EM, Chibnik LB, Keenan BT, Ottoboni L., Raj T., Tang A., Rosenkrantz LL, Imboywa S., Lee M., Von Korff A., Alzheimer Disease Neuroimaging Initiative, Morris MC, Evans DA, Johnson K., Sperling RA, Schneider JA, Bennett DA, and De Jager PL Nature neuroscience, 2013/07/01, Volume 16, Issue 7, p.848-50, (2013) Read More / View Supplemental Materials
Abstract
Common risk alleles for inflammatory diseases are targets of recent positive selection.Raj, T., Kuchroo M., Replogle JM, Raychaudhuri S., Stranger BE, and De Jager PL American journal of human genetics, 2013/04/04, Volume 92, Issue 4, p.517-29, (2013) Read More / View Supplemental Materials
Abstract
Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues.Zhu, J., Adli M., Zou JY, Verstappen G., Coyne M., Zhang X., Durham T., Miri M., Deshpande V., De Jager PL, Bennett DA, Houmard JA, Muoio DM, Onder TT, Camahort R., Cowan CA, Meissner A., Epstein CB, Shoresh N., and Bernstein BE Cell, 2013/01/31, Volume 152, Issue 3, p.642-54, (2013) Read More / View Supplemental Materials
Abstract
2012
Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity.Stranger, BE, and De Jager PL Current opinion in immunology, 2012/10/01, Volume 24, Issue 5, p.544-51, (2012) Read More / View Supplemental Materials
Abstract
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.Ottoboni, L., Keenan BT, Tamayo P., Kuchroo M., Mesirov J. P., Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, and De Jager PL Science translational medicine, 2012/09/26, Volume 4, Issue 153, p.153ra131, (2012) Read More / View Supplemental Materials
Abstract
Alzheimer Disease Susceptibility Loci: Evidence for a Protein Network under Natural Selection.Raj, T., Shulman JM, Keenan BT, Chibnik LB, Evans DA, Bennett DA, Stranger BE, and De Jager PL American journal of human genetics, 2012/04/06, Volume 90, Issue 4, p.720-6, (2012) Read More / View Supplemental Materials
Abstract
Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.Biffi, A., Shulman JM, Jagiella JM, Cortellini L., Ayres AM, Schwab K., Brown DL, Silliman SL, Selim M., Worrall BB, Meschia JF, Slowik A., De Jager PL, Greenberg SM, Schneider JA, Bennett DA, and Rosand J. Neurology, 2012/01/18, (2012) Read More / View Supplemental Materials
Abstract
2011
The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease.Yu, L., Shulman JM, Chibnik L., Leurgans S., Schneider JA, De Jager PL, and Bennett DA Aging cell, 2011/11/28, (2011) Read More / View Supplemental Materials
Abstract
A genome-wide scan for common variants affecting the rate of age-related cognitive decline.De Jager, PL, Shulman JM, Chibnik LB, Keenan BT, Raj T., Wilson RS, Yu L., Leurgans SE, Tran D., Aubin C., Anderson CD, Biffi A., Corneveaux JJ, Huentelman MJ, Alzheimer's Disease Neuroimaging Initiative, Rosand J., Daly M. J., Myers AJ, Reiman EM, Bennett DA, et al. Neurobiology of aging, 2011/11/03, (2011) Read More / View Supplemental Materials
Abstract
2009
Automated high-dimensional flow cytometric data analysis.Pyne, S., Hu X., Wang K., Rossin E., Lin TI, Maier LM, Baecher-Allan C., McLachlan GJ, Tamayo P., Hafler DA, De Jager PL, and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2009/05/26, Volume 106, Issue 21, p.8519-24, (2009) Read More / View Supplemental Materials
Abstract
2008
Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.Choy, E., Yelensky R., Bonakdar S., Plenge RM, Saxena R., De Jager PL, Shaw SY, Wolfish CS, Slavik JM, Cotsapas C., Rivas M., Dermitzakis ET, Cahir-McFarland E., Kieff E., Hafler D., Daly M. J., and Altshuler D. PLoS genetics, 2008/11/01, Volume 4, Issue 11, p.e1000287, (2008) Read More / View Supplemental Materials
Abstract
2007
Risk alleles for multiple sclerosis identified by a genomewide study.International Multiple Sclerosis Genetics, Consortium, Hafler DA, Compston A., Sawcer S., Lander E. S., Daly M. J., De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B., Oksenberg JR, and Hauser SL The New England journal of medicine, 2007/08/30, Volume 357, Issue 9, p.851-62, (2007) Read More / View Supplemental Materials
Abstract
A second major histocompatibility complex susceptibility locus for multiple sclerosis.Yeo, TW, De Jager PL, Gregory SG, Barcellos LF, Walton A., Goris A., Fenoglio C., Ban M., Taylor CJ, Goodman RS, Walsh E., Wolfish CS, Horton R., Traherne J., Beck S., Trowsdale J., Caillier SJ, Ivinson AJ, Green T., Pobywajlo S., et al. Annals of neurology, 2007/03/01, Volume 61, Issue 3, p.228-36, (2007) Read More / View Supplemental Materials
Abstract
2005
A high-density screen for linkage in multiple sclerosis.Sawcer, S., Ban M., Maranian M., Yeo TW, Compston A., Kirby A., Daly M. J., De Jager PL, Walsh E., Lander E. S., Rioux JD, Hafler DA, Ivinson A., Rimmler J., Gregory SG, Schmidt S., Pericak-Vance MA, Akesson E., Hillert J., Datta P., et al. American journal of human genetics, 2005/09/01, Volume 77, Issue 3, p.454-67, (2005) Read More / View Supplemental Materials
Abstract
2004
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.Sawcer, SJ, Maranian M., Singlehurst S., Yeo T., Compston A., Daly M. J., De Jager PL, Gabriel S., Hafler DA, Ivinson AJ, Lander E. S., Rioux JD, Walsh E., Gregory SG, Schmidt S., Pericak-Vance MA, Barcellos L., Hauser SL, Oksenberg JR, Kenealy SJ, et al. Human molecular genetics, 2004/09/01, Volume 13, Issue 17, p.1943-9, (2004) Read More / View Supplemental Materials
Abstract
  • Showing 1-25 of 25 Results