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2016
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.Yamano, T., Nishimasu H., Zetsche B., Hirano H., Slaymaker IM, Li Y., Fedorova I., Nakane T., Makarova KS, Koonin EV, Ishitani R., Zhang F., and Nureki O. Cell, 2016/04/21, (2016) Read More / View Supplemental Materials
Abstract
Genetic Association of Curative and Adverse Reactions to Tyrosine Kinase Inhibitors in Chinese advanced Non-Small Cell Lung Cancer patients.Ruan, Y., Jiang J., Guo L., Li Y., Huang H., Shen L., Luan M., Li M., Du H., Ma C., He L., Zhang X., and Qin S. Scientific reports, 2016/03/18, Volume 6, p.23368, (2016) Read More / View Supplemental Materials
Abstract
Gene expression inference with deep learning.Chen, Y., Li Y., Narayan R., Subramanian A., and Xie X. Bioinformatics (Oxford, England), 2016/02/11, (2016) Read More / View Supplemental Materials
Abstract
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.Pattaro, C., Teumer A., Gorski M., Chu AY, Li M., Mijatovic V., Garnaas M., Tin A., Sorice R., Li Y., Taliun D., Olden M., Foster M., Yang Q., Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C., Tayo B., et al. Nature communications, 2016/01/21, Volume 7, p.10023, (2016) Read More / View Supplemental Materials
Abstract
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Klionsky, DJ, Abdelmohsen K., Abe A., Abedin MJ, Abeliovich H., Acevedo Arozena A., Adachi H., Adams CM, Adams PD, Adeli K., Adhihetty PJ, Adler SG, Agam G., Agarwal R., Aghi MK, Agnello M., Agostinis P., Aguilar PV, Aguirre-Ghiso J., Airoldi EM, et al. Autophagy, 2016/01/02, Volume 12, Issue 1, p.1-222, (2016) Read More / View Supplemental Materials
2015
The genomic landscape of juvenile myelomonocytic leukemia.Stieglitz, E., Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T., Esquivel E., Yu A., Seepo S., Olsen SR, Rosenberg M., Archambeault SL, Abusin G., Beckman K., Brown PA, Briones M., Carcamo B., Cooper T., Dahl GV, Emanuel PD, et al. Nature genetics, 2015/11/01, Volume 47, Issue 11, p.1326-33, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.Wagschal, A., Najafi-Shoushtari SH, Wang L., Goedeke L., Sinha S., deLemos AS, Black JC, Ramírez CM, Li Y., Tewhey R., Hatoum I., Shah N., Lu Y., Kristo F., Psychogios N., Vrbanac V., Lu YC, Hla T., de Cabo R., Tsang JS, et al. Nature medicine, 2015/10/26, (2015) Read More / View Supplemental Materials
Abstract
Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells.Yang, BX, El Farran CA, Guo HC, Yu T., Fang HT, Wang HF, Schlesinger S., Seah YF, Goh GY, Neo SP, Li Y., Lorincz MC, Tergaonkar V., Lim TM, Chen L., Gunaratne J., Collins JJ, Goff SP, Daley GQ, Li H., et al. Cell, 2015/09/09, (2015) Read More / View Supplemental Materials
Abstract
Crystal Structure of Staphylococcus aureus Cas9.Nishimasu, H., Cong L., Yan WX, Ran FA, Zetsche B., Li Y., Kurabayashi A., Ishitani R., Zhang F., and Nureki O. Cell, 2015/08/27, Volume 162, Issue 5, p.1113-26, (2015) Read More / View Supplemental Materials
Abstract
Likelihood Based Complex Trait Association Testing for Arbitrary Depth Sequencing Data.Yan, S., Yuan S., Xu Z., Zhang B., Zhang B., Kang G., Byrnes A., and Li Y. Bioinformatics (Oxford, England), 2015/05/14, (2015) Read More / View Supplemental Materials
Abstract
Cell Specific eQTL Analysis without Sorting Cells.Westra, HJ, Arends D., Esko T., Peters MJ, Schurmann C., Schramm K., Kettunen J., Yaghootkar H., Fairfax BP, Andiappan AK, Li Y., Fu J., Karjalainen J., Platteel M., Visschedijk M., Weersma RK, Kasela S., Milani L., Tserel L., Peterson P., et al. PLoS genetics, 2015/05/01, Volume 11, Issue 5, p.e1005223, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.Yin, X., Low HQ, Wang L., Li Y., Ellinghaus E., Han J., Estivill X., Sun L., Zuo X., Shen C., Zhu C., Zhang A., Sanchez F., Padyukov L., Catanese JJ, Krueger GG, Duffin KC, Mucha S., Weichenthal M., Weidinger S., et al. Nature communications, 2015/04/23, Volume 6, p.6916, (2015) Read More / View Supplemental Materials
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Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.Liu, H., Irwanto A., Fu X., Yu G., Yu Y., Sun Y., Wang C., Wang Z., Okada Y., Low H., Li Y., Liany H., Chen M., Bao F., Li J., You J., Zhang Q., Liu J., Chu T., Andiappan AK, et al. Nature genetics, 2015/02/02, (2015) Read More / View Supplemental Materials
Abstract
Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model.Li, Y., Zhao T., Liu B., Halaweish I., Mazitschek R., Duan X., and Alam HB The journal of trauma and acute care surgery, 2015/02/01, Volume 78, Issue 2, p.378-85, (2015) Read More / View Supplemental Materials
Abstract
Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort.Li, Y., Beckman KB, Caberto C., Kazma R., Lum-Jones A., Haiman CA, Marchand LL, Stram DO, Saxena R., and Cheng I. PloS one, 2015/01/01, Volume 10, Issue 9, p.e0136796, (2015) Read More / View Supplemental Materials
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2014
Rapid neurogenesis through transcriptional activation in human stem cells.Busskamp, V., Lewis NE, Guye P., Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J., Li Y., Li S., Stadler M., Weiss R., and Church GM Molecular systems biology, 2014/11/17, Volume 10, Issue 11, p.760, (2014) Read More / View Supplemental Materials
Abstract
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.Swiech, L., Heidenreich M., Banerjee A., Habib N., Li Y., Trombetta J., Sur M., and Zhang F. Nature biotechnology, 2014/10/19, (2014) Read More / View Supplemental Materials
Abstract
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.Cheng, SC, Quintin J., Cramer RA, Shepardson KM, Saeed S., Kumar V., Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A., Manjeri GR, Li Y., Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C., O'Neill LA, Willems P., van de Veerdonk FL, et al. Science (New York, N.Y.), 2014/09/26, Volume 345, Issue 6204, p.1250684, (2014) Read More / View Supplemental Materials
Abstract
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.Bachovchin, DA, Koblan LW, Wu W., Liu Y., Li Y., Zhao P., Woznica I., Shu Y., Lai JH, Poplawski SE, Kiritsy CP, Healey SE, DiMare M., Sanford DG, Munford RS, Bachovchin WW, and Golub T. R. Nature chemical biology, 2014/08/01, Volume 10, Issue 8, p.656-63, (2014) Read More / View Supplemental Materials
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Expansion of biological pathways based on evolutionary inference.Li, Y., Calvo SE, Gutman R., Liu JS, and Mootha VK Cell, 2014/07/03, Volume 158, Issue 1, p.213-25, (2014) Read More / View Supplemental Materials
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Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells.Wang, J., Mikse O., Liao RG, Li Y., Tan L., Janne PA, Gray NS, Wong KK, and Hammerman PS Oncogene, 2014/06/09, (2014) Read More / View Supplemental Materials
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Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.Lange, LA, Hu Y., Zhang H., Xue C., Schmidt EM, Tang ZZ, Bizon C., Lange EM, Smith JD, Turner EH, Jun G., Kang HM, Peloso G., Auer P., Li KP, Flannick J., Zhang J., Fuchsberger C., Gaulton K., Lindgren C., et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.233-45, (2014) Read More / View Supplemental Materials
Abstract
Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.Zhao, T., Li Y., Liu B., Halaweish I., Mazitschek R., and Alam HB The Journal of surgical research, 2014/02/04, (2014) Read More / View Supplemental Materials
Abstract
2013
DNA targeting specificity of RNA-guided Cas9 nucleases.Hsu, PD, Scott DA, Weinstein JA, Ran FA, Konermann S., Agarwala V., Li Y., Fine EJ, Wu X., Shalem O., Cradick TJ, Marraffini LA, Bao G., and Zhang F. Nature biotechnology, 2013/07/21, (2013) Read More / View Supplemental Materials
Abstract
Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1.Tu, D., Zhu Z., Zhou AY, Yun CH, Lee KE, Toms AV, Li Y., Dunn GP, Chan E., Thai T., Yang S., Ficarro SB, Marto JA, Jeon H., Hahn WC, Barbie DA, and Eck MJ Cell reports, 2013/03/28, Volume 3, Issue 3, p.747-58, (2013) Read More / View Supplemental Materials
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2012
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.Voight, BF, Kang HM, Ding J., Palmer CD, Sidore C., Chines PS, Burtt NP, Fuchsberger C., Li Y., Erdmann J., Frayling TM, Heid IM, Jackson AU, Johnson T., Kilpeläinen TO, Lindgren CM, Morris AP, Prokopenko I., Randall JC, Saxena R., et al. PLoS genetics, 2012/08/01, Volume 8, Issue 8, p.e1002793, (2012) Read More / View Supplemental Materials
Abstract
2011
Mapping copy number variation by population-scale genome sequencing.Mills, RE, Walter K., Stewart C., Handsaker RE, Chen K., Alkan C., Abyzov A., Yoon SC, Ye K., Cheetham RK, Chinwalla A., Conrad DF, Fu Y., Grubert F., Hajirasouliha I., Hormozdiari F., Iakoucheva LM, Iqbal Z., Kang S., Kidd JM, et al. Nature, 2011/02/03, Volume 470, Issue 7332, p.59-65, (2011) Read More / View Supplemental Materials
Abstract
2007
Genome-wide detection and characterization of positive selection in human populations.Sabeti, PC, Varilly P., Fry B., Lohmueller J., Hostetter E., Cotsapas C., Xie X., Byrne EH, McCarroll SA, Gaudet R., Schaffner SF, Lander E. S., International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, et al. Nature, 2007/10/18, Volume 449, Issue 7164, p.913-8, (2007) Read More / View Supplemental Materials
Abstract
  • Showing 1-28 of 28 Results