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  • Showing 1-23 of 23 Results
2016
Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci.Walford, GA, Gustafsson S., Rybin D., Stančáková A., Chen H., Liu CT, Hong J., Jensen RA, Rice K., Morris AP, Mägi R., Tönjes A., Prokopenko I., Kleber ME, Delgado G., Silbernagel G., Jackson AU, Appel EV, Grarup N., Lewis JP, et al. Diabetes, 2016/07/14, (2016) Read More / View Supplemental Materials
Abstract
The genetic architecture of type 2 diabetes.Fuchsberger, C., Flannick J., Teslovich TM, Mahajan A., Agarwala V., Gaulton KJ, Ma C., Fontanillas P., Moutsianas L., McCarthy DJ, Rivas MA, Perry JR, Sim X., Blackwell TW, Robertson NR, Rayner NW, Cingolani P., Locke AE, Tajes JF, Highland HM, et al. Nature, 2016/07/11, (2016) Read More / View Supplemental Materials
Abstract
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.Scott, RA, Freitag DF, Li L., Chu AY, Surendran P., Young R., Grarup N., Stancáková A., Chen Y., Varga TV, Yaghootkar H., Luan J., Zhao JH, Willems SM, Wessel J., Wang S., Maruthur N., Michailidou K., Pirie A., van der Lee SJ, et al. Science translational medicine, 2016/06/01, Volume 8, Issue 341, p.341ra76, (2016) Read More / View Supplemental Materials
Abstract
Integrative approaches for large-scale transcriptome-wide association studies.Gusev, A., Ko A., Shi H., Bhatia G., Chung W., Penninx BW, Jansen R., de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E., Alvarez M., Civelek M., Lusis AJ, Lehtimäki T., Raitoharju E., Kähönen M., Seppälä I., Raitakari OT, et al. Nature genetics, 2016/02/08, (2016) Read More / View Supplemental Materials
Abstract
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Lu, Y., Day FR, Gustafsson S., Buchkovich ML, Na J., Bataille V., Cousminer DL, Dastani Z., Drong AW, Esko T., Evans DM, Falchi M., Feitosa MF, Ferreira T., Hedman Å. K., Haring R., Hysi PG, Iles MM, Justice AE, Kanoni S., et al. Nature communications, 2016/02/01, Volume 7, p.10495, (2016) Read More / View Supplemental Materials
Abstract
Quantifying prion disease penetrance using large population control cohorts.Minikel, EV, Vallabh SM, Lek M., Estrada K., Samocha KE, Sathirapongsasuti JF, McLean CY, Tung JY, Yu LP, Gambetti P., Blevins J., Zhang S., Cohen Y., Chen W., Yamada M., Hamaguchi T., Sanjo N., Mizusawa H., Nakamura Y., Kitamoto T., et al. Science translational medicine, 2016/01/20, Volume 8, Issue 322, p.322ra9, (2016) Read More / View Supplemental Materials
Abstract
2015
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.Gaulton, KJ, Ferreira T., Lee Y., Raimondo A., Mägi R., Reschen ME, Mahajan A., Locke A., William Rayner N., Robertson N., Scott RA, Prokopenko I., Scott LJ, Green T., Sparso T., Thuillier D., Yengo L., Grallert H., Wahl S., Frånberg M., et al. Nature genetics, 2015/11/09, (2015) Read More / View Supplemental Materials
Abstract
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.Winkler, TW, Justice AE, Graff M., Barata L., Feitosa MF, Chu S., Czajkowski J., Esko T., Fall T., Kilpeläinen TO, Lu Y., Mägi R., Mihailov E., Pers TH, Rüeger S., Teumer A., Ehret GB, Ferreira T., Heard-Costa NL, Karjalainen J., et al. PLoS genetics, 2015/10/01, Volume 11, Issue 10, p.e1005378, (2015) Read More / View Supplemental Materials
Abstract
Directional dominance on stature and cognition in diverse human populations.Joshi, PK, Esko T., Mattsson H., Eklund N., Gandin I., Nutile T., Jackson AU, Schurmann C., Smith AV, Zhang W., Okada Y., Stančáková A., Faul JD, Zhao W., Bartz TM, Concas MP, Franceschini N., Enroth S., Vitart V., Trompet S., et al. Nature, 2015/07/01, (2015) Read More / View Supplemental Materials
Abstract
Genetic studies of body mass index yield new insights for obesity biology.Locke, AE, Kahali B., Berndt SI, Justice AE, Pers TH, Day FR, Powell C., Vedantam S., Buchkovich ML, Yang J., Croteau-Chonka DC, Esko T., Fall T., Ferreira T., Gustafsson S., Kutalik Z., Luan J., Mägi R., Randall JC, Winkler TW, et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.197-206, (2015) Read More / View Supplemental Materials
Abstract
New genetic loci link adipose and insulin biology to body fat distribution.Shungin, D., Winkler TW, Croteau-Chonka DC, Ferreira T., Locke AE, Mägi R., Strawbridge RJ, Pers TH, Fischer K., Justice AE, Workalemahu T., Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C., Gustafsson S., Day FR, Esko T., et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.187-96, (2015) Read More / View Supplemental Materials
Abstract
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.Wessel, J., Chu AY, Willems SM, Wang S., Yaghootkar H., Brody JA, Dauriz M., Hivert MF, Raghavan S., Lipovich L., Hidalgo B., Fox K., Huffman JE, An P., Lu Y., Rasmussen-Torvik LJ, Grarup N., Ehm MG, Li L., Baldridge AS, et al. Nature communications, 2015/01/29, Volume 6, p.5897, (2015) Read More / View Supplemental Materials
Abstract
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.Mahajan, A., Sim X., Ng HJ, Manning A., Rivas MA, Highland HM, Locke AE, Grarup N., Im HK, Cingolani P., Flannick J., Fontanillas P., Fuchsberger C., Gaulton KJ, Teslovich TM, Rayner NW, Robertson NR, Beer NL, Rundle JK, Bork-Jensen J., et al. PLoS genetics, 2015/01/01, Volume 11, Issue 1, p.e1004876, (2015) Read More / View Supplemental Materials
Abstract
2014
Defining the role of common variation in the genomic and biological architecture of adult human height.Wood, AR, Esko T., Yang J., Vedantam S., Pers TH, Gustafsson S., Chu AY, Estrada K., Luan J., Kutalik Z., Amin N., Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y., Fall T., Fehrmann R., Ferreira T., Jackson AU, Karjalainen J., et al. Nature genetics, 2014/10/05, (2014) Read More / View Supplemental Materials
Abstract
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.Lim, ET, Würtz P., Havulinna AS, Palta P., Tukiainen T., Rehnström K., Esko T., Mägi R., Inouye M., Lappalainen T., Chan Y., Salem RM, Lek M., Flannick J., Sim X., Manning A., Ladenvall C., Bumpstead S., Hämäläinen E., Aalto K., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004494, (2014) Read More / View Supplemental Materials
Abstract
A Central Role for GRB10 in Regulation of Islet Function in Man.Prokopenko, I., Poon W., Mägi R., Prasad B R., Salehi SA, Almgren P., Osmark P., Bouatia-Naji N., Wierup N., Fall T., Stančáková A., Barker A., Lagou V., Osmond C., Xie W., Lahti J., Jackson AU, Cheng YC, Liu J., O'Connell JR, et al. PLoS genetics, 2014/04/01, Volume 10, Issue 4, p.e1004235, (2014) Read More / View Supplemental Materials
Abstract
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Flannick, J., Thorleifsson G., Beer NL, Jacobs SB, Grarup N., Burtt NP, Mahajan A., Fuchsberger C., Atzmon G., Benediktsson R., Blangero J., Bowden DW, Brandslund I., Brosnan J., Burslem F., Chambers J., Cho YS, Christensen C., Douglas DA, Duggirala R., et al. Nature genetics, 2014/04/01, Volume 46, Issue 4, p.357-63, (2014) Read More / View Supplemental Materials
Abstract
2013
Common variants associated with plasma triglycerides and risk for coronary artery disease.Do, R., Willer CJ, Schmidt EM, Sengupta S., Gao C., Peloso GM, Gustafsson S., Kanoni S., Ganna A., Chen J., Buchkovich ML, Mora S., Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A., Den Hertog HM, Donnelly LA, Ehret GB, Esko T., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1345-52, (2013) Read More / View Supplemental Materials
Abstract
2012
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Manning, AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N., Chen H., Rybin D., Liu CT, Bielak LF, Prokopenko I., Amin N., Barnes D., Cadby G., Hottenga JJ, Ingelsson E., Jackson AU, Johnson T., Kanoni S., Ladenvall C., Lagou V., et al. Nature genetics, 2012/05/13, Volume 44, Issue 6, p.659-669, (2012) Read More / View Supplemental Materials
Abstract
2010
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Speliotes, EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G., Jackson AU, Allen HL, Lindgren CM, Luan J., Mägi R., Randall JC, Vedantam S., Winkler TW, Qi L., Workalemahu T., Heid IM, Steinthorsdottir V., Stringham HM, Weedon MN, Wheeler E., et al. Nature genetics, 2010/11/01, Volume 42, Issue 11, p.937-48, (2010) Read More / View Supplemental Materials
Abstract
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Voight, BF, Scott LJ, Steinthorsdottir V., Morris AP, Dina C., Welch RP, Zeggini E., Huth C., Aulchenko YS, Thorleifsson G., McCulloch LJ, Ferreira T., Grallert H., Amin N., Wu G., Willer CJ, Raychaudhuri S., McCarroll SA, Langenberg C., Hofmann OM, et al. Nature genetics, 2010/07/01, Volume 42, Issue 7, p.579-89, (2010) Read More / View Supplemental Materials
Abstract
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.Saxena, R., Hivert MF, Langenberg C., Tanaka T., Pankow JS, Vollenweider P., Lyssenko V., Bouatia-Naji N., Dupuis J., Jackson AU, Kao WH, Li M., Glazer NL, Manning AK, Luan J., Stringham HM, Prokopenko I., Johnson T., Grarup N., Boesgaard TW, et al. Nature genetics, 2010/02/01, Volume 42, Issue 2, p.142-8, (2010) Read More / View Supplemental Materials
Abstract
2004
Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.Rioux, JD, Karinen H., Kocher K., McMahon SG, Kärkkäinen P., Janatuinen E., Heikkinen M., Julkunen R., Pihlajamäki J., Naukkarinen A., Kosma VM, Daly M. J., Lander E. S., and Laakso M. American journal of medical genetics. Part A, 2004/11/01, Volume 130A, Issue 4, p.345-50, (2004) Read More / View Supplemental Materials
Abstract
  • Showing 1-23 of 23 Results