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2016
Association of Exome Sequences with Cardiovascular Traits among African Americans in the Jackson Heart Study.Peloso, GM, Lange LA, Varga TV, Nickerson DA, Smith JD, Griswold ME, Musani S., Polfus LM, Mei H., Gabriel S., Quarells RC, Altshuler D., Boerwinkle E., Daly M. J., Neale B., Correa A., Reiner AP, Wilson JG, and Kathiresan S. Circulation. Cardiovascular genetics, 2016/07/15, (2016) Read More / View Supplemental Materials
Abstract
Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.Chami, N., Chen MH, Slater AJ, Eicher JD, Evangelou E., Tajuddin SM, Love-Gregory L., Kacprowski T., Schick UM, Nomura A., Giri A., Lessard S., Brody JA, Schurmann C., Pankratz N., Yanek LR, Manichaikul A., Pazoki R., Mihailov E., Hill WD, et al. American journal of human genetics, 2016/06/21, (2016) Read More / View Supplemental Materials
Abstract
Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.Eicher, JD, Chami N., Kacprowski T., Nomura A., Chen MH, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N., Polfus L., Schurmann C., Giri A., Brody JA, Lange LA, Manichaikul A., Hill WD, Pazoki R., Elliot P., Evangelou E., et al. American journal of human genetics, 2016/06/21, (2016) Read More / View Supplemental Materials
Abstract
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.Scott, RA, Freitag DF, Li L., Chu AY, Surendran P., Young R., Grarup N., Stancáková A., Chen Y., Varga TV, Yaghootkar H., Luan J., Zhao JH, Willems SM, Wessel J., Wang S., Maruthur N., Michailidou K., Pirie A., van der Lee SJ, et al. Science translational medicine, 2016/06/01, Volume 8, Issue 341, p.341ra76, (2016) Read More / View Supplemental Materials
Abstract
PCSK9 Inhibitors.Natarajan, P., and Kathiresan S. Cell, 2016/05/19, Volume 165, Issue 5, p.1037, (2016) Read More / View Supplemental Materials
Abstract
Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution.Patel, AP, Peloso GM, Pirruccello JP, Johansen CT, Dubé JB, Larach DB, Ban MR, Dallinge-Thie GM, Gupta N., Boehnke M., Abecasis GR, Kastelein JJ, Hovingh GK, Hegele RA, Rader DJ, and Kathiresan S. Atherosclerosis, 2016/04/23, Volume 250, p.63-68, (2016) Read More / View Supplemental Materials
Abstract
Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia.Khera, AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X., van Leeuwen EM, Natarajan P., Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N., Nomura A., Kessler T., Duga S., Bis JC, van Duijn CM, Cupples LA, Psaty B., et al. Journal of the American College of Cardiology, 2016/03/28, (2016) Read More / View Supplemental Materials
Abstract
Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits.Golbus, JR, Stitziel NO, Zhao W., Xue C., Farrall M., McPherson R., Erdmann J., Deloukas P., Watkins H., Schunkert H., Samani NJ, Saleheen D., Kathiresan S., and Reilly MP Circulation. Cardiovascular genetics, 2016/03/24, (2016) Read More / View Supplemental Materials
Abstract
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.Zanoni, P., Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M., DerOhannessian S., Kontush A., Surendran P., Saleheen D., Trompet S., Jukema JW, De Craen A., Deloukas P., Sattar N., Ford I., Packard C., Majumder Aa, Alam DS, Di Angelantonio E., et al. Science (New York, N.Y.), 2016/03/11, Volume 351, Issue 6278, p.1166-71, (2016) Read More / View Supplemental Materials
Abstract
Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels.Boettger, LM, Salem RM, Handsaker RE, Peloso GM, Kathiresan S., Hirschhorn JN, and McCarroll SA Nature genetics, 2016/02/22, (2016) Read More / View Supplemental Materials
Abstract
Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis.Musunuru, K., and Kathiresan S. Circulation research, 2016/02/19, Volume 118, Issue 4, p.579-85, (2016) Read More / View Supplemental Materials
Abstract
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study.Keenan, T., Zhao W., Rasheed A., Ho WK, Malik R., Felix JF, Young R., Shah N., Samuel M., Sheikh N., Mucksavage ML, Shah O., Li J., Morley M., Laser A., Mallick NH, Zaman KS, Ishaq M., Rasheed SZ, Memon FU, et al. Journal of the American College of Cardiology, 2016/02/02, Volume 67, Issue 4, p.407-16, (2016) Read More / View Supplemental Materials
Abstract
A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans.Clapham, KR, Chu AY, Wessel J., Natarajan P., Flannick J., Rivas MA, Sartori S., Mehran R., Baber U., Fuster V., Scott RA, Rader DJ, Boehnke M., McCarthy MI, Altshuler DM, Kathiresan S., and Peloso GM BMC endocrine disorders, 2016/01/28, Volume 16, Issue 1, p.7, (2016) Read More / View Supplemental Materials
Abstract
An eMERGE Clinical Center at Partners Personalized Medicine.Smoller, JW, Karlson EW, Green RC, Kathiresan S., Macarthur DG, Talkowski ME, Murphy SN, and Weiss ST Journal of personalized medicine, 2016/01/20, Volume 6, Issue 1, (2016) Read More / View Supplemental Materials
Abstract
2015
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.Gaulton, KJ, Ferreira T., Lee Y., Raimondo A., Mägi R., Reschen ME, Mahajan A., Locke A., William Rayner N., Robertson N., Scott RA, Prokopenko I., Scott LJ, Green T., Sparso T., Thuillier D., Yengo L., Grallert H., Wahl S., Frånberg M., et al. Nature genetics, 2015/11/09, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.Wagschal, A., Najafi-Shoushtari SH, Wang L., Goedeke L., Sinha S., deLemos AS, Black JC, Ramírez CM, Li Y., Tewhey R., Hatoum I., Shah N., Lu Y., Kristo F., Psychogios N., Vrbanac V., Lu YC, Hla T., de Cabo R., Tsang JS, et al. Nature medicine, 2015/10/26, (2015) Read More / View Supplemental Materials
Abstract
Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy.Nomura, A., Tada H., Teramoto R., Konno T., Hodatsu A., Won HH, Kathiresan S., Ino H., Fujino N., Yamagishi M., and Hayashi K. Journal of cardiology, 2015/10/03, (2015) Read More / View Supplemental Materials
Abstract
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.Winkler, TW, Justice AE, Graff M., Barata L., Feitosa MF, Chu S., Czajkowski J., Esko T., Fall T., Kilpeläinen TO, Lu Y., Mägi R., Mihailov E., Pers TH, Rüeger S., Teumer A., Ehret GB, Ferreira T., Heard-Costa NL, Karjalainen J., et al. PLoS genetics, 2015/10/01, Volume 11, Issue 10, p.e1005378, (2015) Read More / View Supplemental Materials
Abstract
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.Vilhjálmsson, BJ, Yang J., Finucane HK, Gusev A., Lindström S., Ripke S., Genovese G., Loh PR, Bhatia G., Do R., Hayeck T., Won HH, and of in study Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery Biology Risk Inherited Variants Breast Cancer(DRIVE), Kathiresan S., Pato M., Pato C., Tamimi R., Stahl E., Zaitlen N., Pasaniuc B., et al. American journal of human genetics, 2015/10/01, Volume 97, Issue 4, p.576-92, (2015) Read More / View Supplemental Materials
Abstract
Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.Tada, H., Melander O., Louie JZ, Catanese JJ, Rowland CM, Devlin JJ, Kathiresan S., and Shiffman D. European heart journal, 2015/09/20, (2015) Read More / View Supplemental Materials
Abstract
Phenotypic extremes in rare variant study designs.Peloso, GM, Rader DJ, Gabriel S., Kathiresan S., Daly M. J., and Neale BM European journal of human genetics : EJHG, 2015/09/09, (2015) Read More / View Supplemental Materials
Abstract
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.Jansen, H., Loley C., Lieb W., Pencina MJ, Nelson CP, Kathiresan S., Peloso GM, Voight BF, Reilly MP, Assimes TL, Boerwinkle E., Hengstenberg C., Laaksonen R., McPherson R., Roberts R., Thorsteinsdottir U., Peters A., Gieger C., Rawal R., Thompson JR, et al. Atherosclerosis, 2015/06/03, Volume 241, Issue 2, p.419-426, (2015) Read More / View Supplemental Materials
Abstract
Developing Medicines That Mimic the Natural Successes of the Human Genome: Lessons From NPC1L1, HMGCR, PCSK9, APOC3, and CETP.Kathiresan, S. Journal of the American College of Cardiology, 2015/04/21, Volume 65, Issue 15, p.1562-6, (2015) Read More / View Supplemental Materials
Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries.Beaudoin, M., Gupta RM, Won HH, Lo KS, Do R., Henderson CA, Lavoie-St-Amour C., Langlois S., Rivas D., Lehoux S., Kathiresan S., Tardif JC, Musunuru K., and Lettre G. Arteriosclerosis, thrombosis, and vascular biology, 2015/04/02, (2015) Read More / View Supplemental Materials
Abstract
Genetic studies of body mass index yield new insights for obesity biology.Locke, AE, Kahali B., Berndt SI, Justice AE, Pers TH, Day FR, Powell C., Vedantam S., Buchkovich ML, Yang J., Croteau-Chonka DC, Esko T., Fall T., Ferreira T., Gustafsson S., Kutalik Z., Luan J., Mägi R., Randall JC, Winkler TW, et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.197-206, (2015) Read More / View Supplemental Materials
Abstract
Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction.Thormaehlen, AS, Schuberth C., Won HH, Blattmann P., Joggerst-Thomalla B., Theiss S., Asselta R., Duga S., Merlini PA, Ardissino D., Lander E. S., Gabriel S., Rader DJ, Peloso GM, Pepperkok R., Kathiresan S., and Runz H. PLoS genetics, 2015/02/01, Volume 11, Issue 2, p.e1004855, (2015) Read More / View Supplemental Materials
Abstract
Exome Sequencing in Suspected Monogenic Dyslipidemias.Stitziel, NO, Peloso GM, Abifadel M., Cefalù AB, Fouchier S., Motazacker MM, Tada H., Larach DB, Awan Z., Haller JF, Pullinger CR, Varret M., Rabès JP, Noto D., Tarugi P., Kawashiri MA, Nohara A., Yamagishi M., Risman M., Deo R., et al. Circulation. Cardiovascular genetics, 2015/01/27, (2015) Read More / View Supplemental Materials
Abstract
Analysis of Gene-Gene Interactions among Common Variants in Candidate Cardiovascular Genes in Coronary Artery Disease.Musameh, MD, Wang WY, Nelson CP, Lluís-Ganella C., Debiec R., Subirana I., Elosua R., Balmforth AJ, Ball SG, Hall AS, Kathiresan S., Thompson JR, Lucas G., Samani NJ, and Tomaszewski M. PloS one, 2015/01/01, Volume 10, Issue 2, p.e0117684, (2015) Read More / View Supplemental Materials
Abstract
2014
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes.Jaiswal, S., Fontanillas P., Flannick J., Manning A., Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N., Chavez A., Higgins JM, Moltchanov V., Kuo FC, Kluk MJ, Henderson B., Kinnunen L., Koistinen HA, Ladenvall C., Getz G., Correa A., et al. The New England journal of medicine, 2014/11/26, (2014) Read More / View Supplemental Materials
Abstract
Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans.Naik, RP, Derebail VK, Grams ME, Franceschini N., Auer PL, Peloso GM, Young BA, Lettre G., Peralta CA, Katz R., Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P., Rich SS, Smith JD, Boerwinkle E., Rosamond WD, Ito K., et al. JAMA, 2014/11/26, Volume 312, Issue 20, p.2115-2125, (2014) Read More / View Supplemental Materials
Abstract
Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.Smith, JG, Luk K., Schulz CA, Engert JC, Do R., Hindy G., Rukh G., Dufresne L., Almgren P., Owens DS, Harris TB, Peloso GM, Kerr KF, Wong Q., Smith AV, Budoff MJ, Rotter JI, Cupples LA, Rich S., Kathiresan S., et al. JAMA, 2014/11/05, Volume 312, Issue 17, p.1764-1771, (2014) Read More / View Supplemental Materials
Abstract
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.Swerdlow, DI, Preiss D., Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T., Sofat R., Stender S., Johnson PC, Scott RA, Leusink M., Verweij N., Sharp SJ, Guo Y., Giambartolomei C., Chung C., Peasey A., Amuzu A., Li K., Palmen J., et al. Lancet, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
Association of exome sequences with plasma C-reactive protein levels in >9000 participants.Schick, UM, Auer PL, Bis JC, Lin H., Wei P., Pankratz N., Lange LA, Brody J., Stitziel NO, Kim DS, Carlson CS, Fornage M., Haessler J., Hsu L., Jackson RD, Kooperberg C., Leal SM, Psaty BM, Boerwinkle E., Tracy R., et al. Human molecular genetics, 2014/09/03, (2014) Read More / View Supplemental Materials
Abstract
Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.Tada, H., Won HH, Melander O., Yang J., Peloso GM, and Kathiresan S. Circulation. Cardiovascular genetics, 2014/08/28, (2014) Read More / View Supplemental Materials
Abstract
Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.Tada, H., Shiffman D., Smith JG, Sjögren M., Lubitz SA, Ellinor PT, Louie JZ, Catanese JJ, Engström G., Devlin JJ, Kathiresan S., and Melander O. Stroke; a journal of cerebral circulation, 2014/08/14, (2014) Read More / View Supplemental Materials
Abstract
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.and TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung Blood Institute, Crosby J., Peloso GM, Auer PL, Crosslin DR, Stitziel NO, Lange LA, Lu Y., Tang ZZ, Zhang H., Hindy G., Masca N., Stirrups K., Kanoni S., Do R., Jun G., Hu Y., Kang HM, Xue C., Goel A., et al. The New England journal of medicine, 2014/07/03, Volume 371, Issue 1, p.22-31, (2014) Read More / View Supplemental Materials
Abstract
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.Lim, ET, Würtz P., Havulinna AS, Palta P., Tukiainen T., Rehnström K., Esko T., Mägi R., Inouye M., Lappalainen T., Chan Y., Salem RM, Lek M., Flannick J., Sim X., Manning A., Ladenvall C., Bumpstead S., Hämäläinen E., Aalto K., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004494, (2014) Read More / View Supplemental Materials
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Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.Mäkinen, VP, Civelek M., Meng Q., Zhang B., Zhu J., Levian C., Huan T., Segrè AV, Ghosh S., Vivar J., Nikpay M., Stewart AF, Nelson CP, Willenborg C., Erdmann J., Blakenberg S., O'Donnell CJ, März W., Laaksonen R., Epstein SE, et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004502, (2014) Read More / View Supplemental Materials
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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Flannick, J., Thorleifsson G., Beer NL, Jacobs SB, Grarup N., Burtt NP, Mahajan A., Fuchsberger C., Atzmon G., Benediktsson R., Blangero J., Bowden DW, Brandslund I., Brosnan J., Burslem F., Chambers J., Cho YS, Christensen C., Douglas DA, Duggirala R., et al. Nature genetics, 2014/04/01, Volume 46, Issue 4, p.357-63, (2014) Read More / View Supplemental Materials
Abstract
Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2.Huang, J., Huffman JE, Yamkauchi M., Trompet S., Asselbergs FW, Sabater-Lleal M., Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W., Dehghan A., Johnson AD, Truong V., Folkersen L., Yang Q., Oudot-Mellkah T., Buckley BM, et al. Arteriosclerosis, thrombosis, and vascular biology, 2014/02/27, (2014) Read More / View Supplemental Materials
Abstract
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.Peloso, GM, Auer PL, Bis JC, Voorman A., Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M., Isaacs A., Jakobsdottir J., Feitosa MF, Davies G., Huffman JE, Manichaikul A., Davis B., Lohman K., Joon AY, Smith AV, et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.223-32, (2014) Read More / View Supplemental Materials
Abstract
Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.Lange, LA, Hu Y., Zhang H., Xue C., Schmidt EM, Tang ZZ, Bizon C., Lange EM, Smith JD, Turner EH, Jun G., Kang HM, Peloso G., Auer P., Li KP, Flannick J., Zhang J., Fuchsberger C., Gaulton K., Lindgren C., et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.233-45, (2014) Read More / View Supplemental Materials
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Searching for missing heritability: Designing rare variant association studies.Zuk, O., Schaffner SF, Samocha K., Do R., Hechter E., Kathiresan S., Daly M. J., Neale BM, Sunyaev SR, and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2014/01/28, Volume 111, Issue 4, p.E455-64, (2014) Read More / View Supplemental Materials
Abstract
Predicting Stroke Through Genetic Risk Functions: The CHARGE Risk Score Project.Ibrahim-Verbaas, CA, Fornage M., Bis JC, Choi SH, Psaty BM, Meigs JB, Rao M., Nalls M., Fontes JD, O'Donnell CJ, Kathiresan S., Ehret GB, Fox CS, Malik R., Dichgans M., Schmidt H., Lahti J., Heckbert SR, Lumley T., Rice K., et al. Stroke; a journal of cerebral circulation, 2014/01/16, (2014) Read More / View Supplemental Materials
Abstract
Analysis of gene-gene interactions among common variants in coronary artery disease.Musameh, M., Wang W., Nelson C., Lluís-Ganella C., Subirana I., Elosua R., Hall A., Kathiresan S., Samani N., and Tomaszewski M. Heart, lung & circulation, 2014/01/01, Volume 23 Suppl 2, p.e19, (2014) Read More / View Supplemental Materials
2013
Meta-analysis of gene-level tests for rare variant association.Liu, DJ, Peloso GM, Zhan X., Holmen OL, Zawistowski M., Feng S., Nikpay M., Auer PL, Goel A., Zhang H., Peters U., Farrall M., Orho-Melander M., Kooperberg C., McPherson R., Watkins H., Willer CJ, Hveem K., Melander O., Kathiresan S., et al. Nature genetics, 2013/12/15, (2013) Read More / View Supplemental Materials
Abstract
Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants.Dichgans, M., Malik R., König IR, Rosand J., Clarke R., Gretarsdottir S., Thorleifsson G., Mitchell BD, Assimes TL, Levi C., Odonnell CJ, Fornage M., Thorsteinsdottir U., Psaty BM, Hengstenberg C., Seshadri S., Erdmann J., Bis JC, Peters A., Boncoraglio GB, et al. Stroke; a journal of cerebral circulation, 2013/11/21, (2013) Read More / View Supplemental Materials
Abstract
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.Flannick, J., Beer NL, Bick AG, Agarwala V., Molnes J., Gupta N., Burtt NP, Florez JC, Meigs JB, Taylor H., Lyssenko V., Irgens H., Fox E., Burslem F., Johansson S., Brosnan MJ, Trimmer JK, Newton-Cheh C., Tuomi T., Molven A., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1380-5, (2013) Read More / View Supplemental Materials
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Common variants associated with plasma triglycerides and risk for coronary artery disease.Do, R., Willer CJ, Schmidt EM, Sengupta S., Gao C., Peloso GM, Gustafsson S., Kanoni S., Ganna A., Chen J., Buchkovich ML, Mora S., Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A., Den Hertog HM, Donnelly LA, Ehret GB, Esko T., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1345-52, (2013) Read More / View Supplemental Materials
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Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia.Stitziel, NO, Fouchier SW, Sjouke B., Peloso GM, Moscoso AM, Auer PL, Goel A., Gigante B., Barnes TA, Melander O., Orho-Melander M., Duga S., Sivapalaratnam S., Nikpay M., Martinelli N., Girelli D., Jackson RD, Kooperberg C., Lange LA, Ardissino D., et al. Arteriosclerosis, thrombosis, and vascular biology, 2013/09/26, (2013) Read More / View Supplemental Materials
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Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls.McLaren, PJ, Coulonges C., Ripke S., van den Berg L., Buchbinder S., Carrington M., Cossarizza A., Dalmau J., Deeks SG, Delaneau O., De Luca A., Goedert JJ, Haas D., Herbeck JT, Kathiresan S., Kirk GD, Lambotte O., Luo M., Mallal S., van Manen D., et al. PLoS pathogens, 2013/07/01, Volume 9, Issue 7, p.e1003515, (2013) Read More / View Supplemental Materials
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A Novel APOB Mutation Identified by Exome Sequencing Cosegregates With Steatosis, Liver Cancer, and Hypocholesterolemia.Cefalù, AB, Pirruccello JP, Noto D., Gabriel S., Valenti V., Gupta N., Spina R., Tarugi P., Kathiresan S., and Averna MR Arteriosclerosis, thrombosis, and vascular biology, 2013/05/30, (2013) Read More / View Supplemental Materials
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Multiple Inflammatory Biomarkers in Relation to Cardiovascular Events and Mortality in the Community.Schnabel, RB, Yin X., Larson MG, Yamamoto JF, Fontes JD, Kathiresan S., Rong J., Levy D., Keaney JF Jr, Wang TJ, Murabito JM, Vasan RS, and Benjamin EJ Arteriosclerosis, thrombosis, and vascular biology, 2013/05/02, (2013) Read More / View Supplemental Materials
Abstract
2012
Will cholesteryl ester transfer protein inhibition succeed primarily by lowering low-density lipoprotein cholesterol?: insights from human genetics and clinical trials.Kathiresan, S. Journal of the American College of Cardiology, 2012/11/13, Volume 60, Issue 20, p.2049-52, (2012) Read More / View Supplemental Materials
Burden of rare sarcomere gene variants in the framingham and jackson heart study cohorts.Bick, AG, Flannick J., Ito K., Cheng S., Vasan RS, Parfenov MG, Herman DS, Depalma SR, Gupta N., Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J., Taylor HA Jr, Fox ER, Newton-Cheh C., Kathiresan S., O'Donnell CJ, Wilson JG, et al. American journal of human genetics, 2012/09/07, Volume 91, Issue 3, p.513-9, (2012) Read More / View Supplemental Materials
Abstract
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.Voight, BF, Kang HM, Ding J., Palmer CD, Sidore C., Chines PS, Burtt NP, Fuchsberger C., Li Y., Erdmann J., Frayling TM, Heid IM, Jackson AU, Johnson T., Kilpeläinen TO, Lindgren CM, Morris AP, Prokopenko I., Randall JC, Saxena R., et al. PLoS genetics, 2012/08/01, Volume 8, Issue 8, p.e1002793, (2012) Read More / View Supplemental Materials
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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.Voight, BF, Peloso GM, Orho-Melander M., Frikke-Schmidt R., Barbalic M., Jensen MK, Hindy G., Hólm H., Ding EL, Johnson T., Schunkert H., Samani NJ, Clarke R., Hopewell JC, Thompson JF, Li M., Thorleifsson G., Newton-Cheh C., Musunuru K., Pirruccello JP, et al. Lancet, 2012/05/17, (2012) Read More / View Supplemental Materials
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Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.Stahl, EA, Wegmann D., Trynka G., Gutierrez-Achury J., Do R., Voight BF, Kraft P., Chen R., Kallberg HJ, Kurreeman FA, Diabetes Genetics Replication and Meta-analysis Consortium, Myocardial Infarction Genetics Consortium, Kathiresan S., Wijmenga C., Gregersen PK, Alfredsson L., Siminovitch KA, Worthington J., de Bakker PI, Raychaudhuri S., et al. Nature genetics, 2012/03/25, (2012) Read More / View Supplemental Materials
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Genetics of human cardiovascular disease.Kathiresan, S., and Srivastava D. Cell, 2012/03/16, Volume 148, Issue 6, p.1242-57, (2012) Read More / View Supplemental Materials
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Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project.Musunuru, K., Romaine SP, Lettre G., Wilson JG, Volcik KA, Tsai MY, Taylor HA Jr, Schreiner PJ, Rotter JI, Rich SS, Redline S., Psaty BM, Papanicolaou GJ, Ordovas JM, Liu K., Krauss RM, Glazer NL, Gabriel SB, Fornage M., Cupples LA, et al. PloS one, 2012/01/01, Volume 7, Issue 5, p.e36473, (2012) Read More / View Supplemental Materials
Abstract
2011
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction.Shea, J., Agarwala V., Philippakis AA, Maguire J., Banks E., DePristo M., Thomson B., Guiducci C., Onofrio RC, Kathiresan S., Gabriel S., Burtt NP, Daly M. J., Groop L., Altshuler D., and Myocardial Infarction Genetics Consortium Nature genetics, 2011/07/24, Volume 43, Issue 8, p.801-5, (2011) Read More / View Supplemental Materials
Abstract
2010
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Speliotes, EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G., Jackson AU, Allen HL, Lindgren CM, Luan J., Mägi R., Randall JC, Vedantam S., Winkler TW, Qi L., Workalemahu T., Heid IM, Steinthorsdottir V., Stringham HM, Weedon MN, Wheeler E., et al. Nature genetics, 2010/11/01, Volume 42, Issue 11, p.937-48, (2010) Read More / View Supplemental Materials
Abstract
Candidate gene association resource (CARe): design, methods, and proof of concept.Musunuru, K., Lettre G., Young T., Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q., Chen MH, Lapchyk N., Crenshaw A., Ziaugra L., Rachupka A., Benjamin EJ, Cupples LA, Fornage M., Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh C., et al. Circulation. Cardiovascular genetics, 2010/06/01, Volume 3, Issue 3, p.267-75, (2010) Read More / View Supplemental Materials
Abstract
2008
HapMap and mapping genes for cardiovascular disease.Musunuru, K., and Kathiresan S. Circulation. Cardiovascular genetics, 2008/10/01, Volume 1, Issue 1, p.66-71, (2008) Read More / View Supplemental Materials
Abstract
2007
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.and of Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes BioMedical Rese, Saxena R., Voight BF, Lyssenko V., Burtt NP, de Bakker PI, Chen H., Roix JJ, Kathiresan S., Hirschhorn JN, Daly M. J., Hughes TE, Groop L., Altshuler D., Almgren P., Florez JC, Meyer J., Ardlie K., Bengtsson Boström K., Isomaa B., et al. Science (New York, N.Y.), 2007/06/01, Volume 316, Issue 5829, p.1331-6, (2007) Read More / View Supplemental Materials
Abstract
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