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2016
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Lu, Y., Day FR, Gustafsson S., Buchkovich ML, Na J., Bataille V., Cousminer DL, Dastani Z., Drong AW, Esko T., Evans DM, Falchi M., Feitosa MF, Ferreira T., Hedman Å. K., Haring R., Hysi PG, Iles MM, Justice AE, Kanoni S., et al. Nature communications, 2016/02/01, Volume 7, p.10495, (2016) Read More / View Supplemental Materials
Abstract
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.Pattaro, C., Teumer A., Gorski M., Chu AY, Li M., Mijatovic V., Garnaas M., Tin A., Sorice R., Li Y., Taliun D., Olden M., Foster M., Yang Q., Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C., Tayo B., et al. Nature communications, 2016/01/21, Volume 7, p.10023, (2016) Read More / View Supplemental Materials
Abstract
Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.Pers, TH, Timshel P., Ripke S., Lent S., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Sullivan PF, O'Donovan MC, Franke L., and Hirschhorn JN Human molecular genetics, 2016/01/10, (2016) Read More / View Supplemental Materials
Abstract
2015
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.Felix, JF, Bradfield JP, Monnereau C., van der Valk RJ, Stergiakouli E., Chesi A., Gaillard R., Feenstra B., Thiering E., Kreiner-Møller E., Mahajan A., Pitkänen N., Joro R., Cavadino A., Huikari V., Franks S., Groen-Blokhuis MM, Cousminer DL, Marsh JA, Lehtimäki T., et al. Human molecular genetics, 2015/11/24, (2015) Read More / View Supplemental Materials
Abstract
Functional implications of disease-specific variants in loci jointly associated to coeliac disease and rheumatoid arthritis.Gutierrez-Achury, J., Zorro MM, Ricaño-Ponce I., Zhernakova DV, consortium Coeliac Disease Immunochip consortium, RACI, Diogo D., Raychaudhuri S., Franke L., Trynka G., Wijmenga C., and Zhernakova A. Human molecular genetics, 2015/11/05, (2015) Read More / View Supplemental Materials
Abstract
The transcriptional landscape of age in human peripheral blood.Peters, MJ, Joehanes R., Pilling LC, Schurmann C., Conneely KN, Powell J., Reinmaa E., Sutphin GL, Zhernakova A., Schramm K., Wilson YA, Kobes S., Tukiainen T., NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M., Liu Y., Gharib SA, Stranger BE, et al. Nature communications, 2015/10/22, Volume 6, p.8570, (2015) Read More / View Supplemental Materials
Abstract
An integrative systems genetics approach reveals potential causal genes and pathways related to obesity.Kogelman, LJ, Zhernakova DV, Westra HJ, Cirera S., Fredholm M., Franke L., and Kadarmideen HN Genome medicine, 2015/10/20, Volume 7, Issue 1, p.105, (2015) Read More / View Supplemental Materials
Abstract
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.Winkler, TW, Justice AE, Graff M., Barata L., Feitosa MF, Chu S., Czajkowski J., Esko T., Fall T., Kilpeläinen TO, Lu Y., Mägi R., Mihailov E., Pers TH, Rüeger S., Teumer A., Ehret GB, Ferreira T., Heard-Costa NL, Karjalainen J., et al. PLoS genetics, 2015/10/01, Volume 11, Issue 10, p.e1005378, (2015) Read More / View Supplemental Materials
Abstract
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.Kato, N., Loh M., Takeuchi F., Verweij N., Wang X., Zhang W., Kelly TN, Saleheen D., Lehne B., Leach IM, Drong AW, Abbott J., Wahl S., Tan ST, Scott WR, Campanella G., Chadeau-Hyam M., Afzal U., Ahluwalia TS, Bonder MJ, et al. Nature genetics, 2015/09/21, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.Draisma, HH, Pool R., Kobl M., Jansen R., Petersen AK, Vaarhorst AA, Yet I., Haller T., Demirkan A., Esko T., Zhu G., Böhringer S., Beekman M., van Klinken JB, Römisch-Margl W., Prehn C., Adamski J., de Craen AJ, van Leeuwen EM, Amin N., et al. Nature communications, 2015/06/12, Volume 6, p.7208, (2015) Read More / View Supplemental Materials
Abstract
Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.Franke, L., El Bannoudi H., Jansen DT, Kok K., Trynka G., Diogo D., Swertz M., Fransen K., Knevel R., Gutierrez-Achury J., Ärlestig L., Greenberg JD, Kremer J., Pappas DA, Kanterakis A., Weersma RK, van der Helm-van Mil AH, Guryev V., Rantapää-Dahlqvist S., Gregersen PK, et al. European journal of human genetics : EJHG, 2015/05/13, (2015) Read More / View Supplemental Materials
Abstract
The impact of low-frequency and rare variants on lipid levels.Surakka, I., Horikoshi M., Mägi R., Sarin AP, Mahajan A., Lagou V., Marullo L., Ferreira T., Miraglio B., Timonen S., Kettunen J., Pirinen M., Karjalainen J., Thorleifsson G., Hägg S., Hottenga JJ, Isaacs A., Ladenvall C., Beekman M., Esko T., et al. Nature genetics, 2015/05/11, (2015) Read More / View Supplemental Materials
Abstract
Cell Specific eQTL Analysis without Sorting Cells.Westra, HJ, Arends D., Esko T., Peters MJ, Schurmann C., Schramm K., Kettunen J., Yaghootkar H., Fairfax BP, Andiappan AK, Li Y., Fu J., Karjalainen J., Platteel M., Visschedijk M., Weersma RK, Kasela S., Milani L., Tserel L., Peterson P., et al. PLoS genetics, 2015/05/01, Volume 11, Issue 5, p.e1005223, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development.Chan, Y., Salem RM, Hsu YH, McMahon G., Pers TH, Vedantam S., Esko T., Guo MH, Lim ET, GIANT Consortium, Franke L., Smith GD, Strachan DP, and Hirschhorn JN American journal of human genetics, 2015/04/08, (2015) Read More / View Supplemental Materials
Abstract
Genetic studies of body mass index yield new insights for obesity biology.Locke, AE, Kahali B., Berndt SI, Justice AE, Pers TH, Day FR, Powell C., Vedantam S., Buchkovich ML, Yang J., Croteau-Chonka DC, Esko T., Fall T., Ferreira T., Gustafsson S., Kutalik Z., Luan J., Mägi R., Randall JC, Winkler TW, et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.197-206, (2015) Read More / View Supplemental Materials
Abstract
New genetic loci link adipose and insulin biology to body fat distribution.Shungin, D., Winkler TW, Croteau-Chonka DC, Ferreira T., Locke AE, Mägi R., Strawbridge RJ, Pers TH, Fischer K., Justice AE, Workalemahu T., Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C., Gustafsson S., Day FR, Esko T., et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.187-96, (2015) Read More / View Supplemental Materials
Abstract
Biological interpretation of genome-wide association studies using predicted gene functions.Pers, TH, Karjalainen JM, Chan Y., Westra HJ, Wood AR, Yang J., Lui JC, Vedantam S., Gustafsson S., Esko T., Frayling T., Speliotes EK, Genetic Investigation of ANthropometric Traits(GIANT) Consortium, Boehnke M., Raychaudhuri S., Fehrmann RS, Hirschhorn JN, and Franke L. Nature communications, 2015/01/19, Volume 6, p.5890, (2015) Read More / View Supplemental Materials
Abstract
Gene expression analysis identifies global gene dosage sensitivity in cancer.Fehrmann, RS, Karjalainen JM, Krajewska M., Westra HJ, Maloney D., Simeonov A., Pers TH, Hirschhorn JN, Jansen RC, Schultes EA, van Haagen HH, de Vries EG, Te Meerman GJ, Wijmenga C., van Vugt MA, and Franke L. Nature genetics, 2015/01/12, (2015) Read More / View Supplemental Materials
Abstract
2014
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.Benyamin, B., Esko T., Ried JS, Radhakrishnan A., Vermeulen SH, Traglia M., Gögele M., Anderson D., Broer L., Podmore C., Luan J., Kutalik Z., Sanna S., van der Meer P., Tanaka T., Wang F., Westra HJ, Franke L., Mihailov E., Milani L., et al. Nature communications, 2014/10/29, Volume 5, p.4926, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.The Coffee and Caffeine Genetics, Consortium, Cornelis MC, Byrne EM, Esko T., Nalls MA, Ganna A., Paynter N., Monda KL, Amin N., Fischer K., Renstrom F., Ngwa JS, Huikari V., Cavadino A., Nolte IM, Teumer A., Yu K., Marques-Vidal P., Rawal R., Manichaikul A., et al. Molecular psychiatry, 2014/10/07, (2014) Read More / View Supplemental Materials
Abstract
Defining the role of common variation in the genomic and biological architecture of adult human height.Wood, AR, Esko T., Yang J., Vedantam S., Pers TH, Gustafsson S., Chu AY, Estrada K., Luan J., Kutalik Z., Amin N., Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y., Fall T., Fehrmann R., Ferreira T., Jackson AU, Karjalainen J., et al. Nature genetics, 2014/10/05, (2014) Read More / View Supplemental Materials
Abstract
A novel common variant in DCST2 is associated with length in early life and height in adulthood.van der Valk, RJ, Kreiner-Møller E., Kooijman MN, Guxens M., Stergiakouli E., Sääf A., Bradfield JP, Geller F., Hayes MG, Cousminer DL, Körner A., Thiering E., Curtin JA, Myhre R., Huikari V., Joro R., Kerkhof M., Warrington NM, Pitkänen N., Ntalla I., et al. Human molecular genetics, 2014/10/03, (2014) Read More / View Supplemental Materials
Abstract
Hemani et al. reply.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/10/02, Volume 514, Issue 7520, p.E5-6, (2014) Read More / View Supplemental Materials
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.Rietveld, CA, Esko T., Davies G., Pers TH, Turley P., Benyamin B., Chabris CF, Emilsson V., Johnson AD, Lee JJ, de Leeuw C., Marioni RE, Medland SE, Miller MB, Rostapshova O., van der Lee SJ, Vinkhuyzen AA, Amin N., Conley D., Derringer J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/09/08, (2014) Read More / View Supplemental Materials
Abstract
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.Kumar, V., Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A., Giamarellos-Bourboulis E., Karjalainen J., Franke L., Withoff S., Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H., Bauer H., Herrmann BG, Bochud PY, Marchetti O., Perfect JR, Xavier RJ, et al. Nature communications, 2014/09/08, Volume 5, p.4675, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.Geller, F., Feenstra B., Carstensen L., Pers TH, van Rooij IA, Körberg IB, Choudhry S., Karjalainen JM, Schnack TH, Hollegaard MV, Feitz WF, Roeleveld N., Hougaard DM, Hirschhorn JN, Franke L., Baskin LS, Nordenskjöld A., van der Zanden LF, and Melbye M. Nature genetics, 2014/08/10, (2014) Read More / View Supplemental Materials
Abstract
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.Perry, JR, Day F., Elks CE, Sulem P., Thompson DJ, Ferreira T., He C., Chasman DI, Esko T., Thorleifsson G., Albrecht E., Ang WQ, Corre T., Cousminer DL, Feenstra B., Franceschini N., Ganna A., Johnson AD, Kjellqvist S., Lunetta KL, et al. Nature, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.Hoggart, CJ, Venturini G., Mangino M., Gomez F., Ascari G., Zhao JH, Teumer A., Winkler TW, Tšernikova N., Luan J., Mihailov E., Ehret GB, Zhang W., Lamparter D., Esko T., Macé A., Rüeger S., Bochud PY, Barcella M., Dauvilliers Y., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004508, (2014) Read More / View Supplemental Materials
Abstract
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.Arking, DE, Pulit SL, Crotti L., van der Harst P., Munroe PB, Koopmann TT, Sotoodehnia N., Rossin EJ, Morley M., Wang X., Johnson AD, Lundby A., Gudbjartsson DF, Noseworthy PA, Eijgelsheim M., Bradford Y., Tarasov KV, Dörr M., Müller-Nurasyid M., Lahtinen AM, et al. Nature genetics, 2014/06/22, (2014) Read More / View Supplemental Materials
Abstract
Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'Deelen, P., Menelaou A., van Leeuwen EM, Kanterakis A., van Dijk F., Medina-Gomez C., Francioli LC, Hottenga JJ, Karssen LC, Estrada K., Kreiner-Møller E., Rivadeneira F., van Setten J., Gutierrez-Achury J., Westra HJ, Franke L., van Enckevort D., Dijkstra M., Byelas H., van Duijn CM, et al. European journal of human genetics : EJHG, 2014/06/04, (2014) Read More / View Supplemental Materials
Abstract
Detection and replication of epistasis influencing transcription in humans.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/02/26, (2014) Read More / View Supplemental Materials
Abstract
2013
Genetics of rheumatoid arthritis contributes to biology and drug discovery.Okada, Y., Wu D., Trynka G., Raj T., Terao C., Ikari K., Kochi Y., Ohmura K., Suzuki A., Yoshida S., Graham RR, Manoharan A., Ortmann W., Bhangale T., Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
Abstract
Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.Li, G., Diogo D., Wu D., Spoonamore J., Dancik V., Franke L., Kurreeman F., Rossin EJ, Duclos G., Hartland C., Zhou X., Li K., Liu J., De Jager PL, Siminovitch KA, Zhernakova A., Raychaudhuri S., Bowes J., Eyre S., Padyukov L., et al. PLoS genetics, 2013/05/01, Volume 9, Issue 5, p.e1003487, (2013) Read More / View Supplemental Materials
Abstract
  • Showing 1-33 of 33 Results