Center of Excellence in Genomic Science

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.

Villani AC, Satija R, Reynolds G, et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science. 2017;356(6335). doi:10.1126/science.aah4573DOI Google Scholar PubMed

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput.

Gierahn TM, Wadsworth MH, Hughes TK, et al. Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput. Nat Methods. 2017;14(4):395-398. doi:10.1038/nmeth.4179DOI Google Scholar PubMed

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28.

Smargon AA, Cox DBT, Pyzocha NK, et al. Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28. Mol Cell. 2017;65(4):618-630.e7. doi:10.1016/j.molcel.2016.12.023DOI Google Scholar PubMed

Scaling single-cell genomics from phenomenology to mechanism.

Tanay A, Regev A. Scaling single-cell genomics from phenomenology to mechanism. Nature. 2017;541(7637):331-338. doi:10.1038/nature21350DOI Google Scholar PubMed

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.

Dixit A, Parnas O, Li B, et al. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016;167(7):1853-1866.e17. doi:10.1016/j.cell.2016.11.038DOI Google Scholar PubMed

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.

Adamson B, Norman TM, Jost M, et al. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016;167(7):1867-1882.e21. doi:10.1016/j.cell.2016.11.048DOI Google Scholar PubMed

Writ large: Genomic dissection of the effect of cellular environment on immune response.

Yosef N, Regev A. Writ large: Genomic dissection of the effect of cellular environment on immune response. Science. 2016;354(6308):64-68. doi:10.1126/science.aaf5453DOI Google Scholar PubMed

High-resolution interrogation of functional elements in the noncoding genome.

Sanjana NE, Wright J, Zheng K, et al. High-resolution interrogation of functional elements in the noncoding genome. Science. 2016;353(6307):1545-1549. doi:10.1126/science.aaf7613DOI Google Scholar PubMed

Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction.

Genshaft AS, Li S, Gallant CJ, et al. Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction. Genome Biol. 2016;17(1):188. doi:10.1186/s13059-016-1045-6DOI Google Scholar PubMed

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.

Abudayyeh OO, Gootenberg JS, Konermann S, et al. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science. 2016;353(6299):aaf5573. doi:10.1126/science.aaf5573DOI Google Scholar PubMed