Cell Circuits Program

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer.

C Y Chen A, Ji KY, Yerinde C, et al. CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer. Cell. 2026. doi:10.1016/j.cell.2026.07.016Google Scholar PubMed DOI

An affinity reagent-conjugated biotin ligase for amplified cell surface labelling in vitro and in vivo.

Holden B, Mutaher M, Raychowdhury R, et al. An affinity reagent-conjugated biotin ligase for amplified cell surface labelling in vitro and in vivo. Scientific reports. 2026. doi:10.1038/s41598-026-46452-7Google Scholar PubMed DOI

Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression.

Hoover PJ, Eisenhaure TM, Hodgin J, et al. Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression. Annals of the rheumatic diseases. 2026. doi:10.1016/j.ard.2026.03.004Google Scholar PubMed DOI

A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis.

Hoover PJ, Raparia C, Lieb DJ, et al. A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis. The Journal of experimental medicine. 2025;222(11). doi:10.1084/jem.20241873Google Scholar PubMed DOI

Cell populations in human breast cancers are molecularly and biologically distinct with age.

Parsons A, Colón ES, Manjunath M, et al. Cell populations in human breast cancers are molecularly and biologically distinct with age. Nature aging. 2025. doi:10.1038/s43587-025-00984-1Google Scholar PubMed DOI

Multiple overlapping binding sites determine transcription factor occupancy.

Khetan S, Carroll BS, Bulyk ML. Multiple overlapping binding sites determine transcription factor occupancy. Nature. 2025. doi:10.1038/s41586-025-09472-3Google Scholar PubMed DOI

Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance.

Gao Y, Felsky D, Reyes-Dumeyer D, et al. Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2022;18(10):1797-1811. doi:10.1002/alz.12524Google Scholar PubMed PubMed Central DOI

PMCID

PMC9170841

Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans.

Ma Y, Yu L, Olah M, et al. Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer’s disease risk in humans. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2022;18(4):688-699. doi:10.1002/alz.12425Google Scholar PubMed PubMed Central DOI

PMCID

PMC9475136

Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer’s disease risk in humans

Ma Y, Yu L, Olah M, et al. Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer’s disease risk in humans. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2020;16(Suppl 2). doi:10.1002/alz.043533Google Scholar PubMed PubMed Central DOI

PMCID

PMC8362904

An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling.

Mertins P, Przybylski D, Yosef N, et al. An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Rep. 2017;19(13):2853-2866. doi:10.1016/j.celrep.2017.06.016Google Scholar PubMed DOI