Infectious Disease and Microbiome Program, Infectious Disease and Microbiome

Deep learning-enabled discovery of antibiotics effective against Neisseria gonorrhoeae.

Anahtar MN, Valeri JA, Modaresi SM, et al. Deep learning-enabled discovery of antibiotics effective against Neisseria gonorrhoeae. Science translational medicine. 2026;18(854):eads4699. doi:10.1126/scitranslmed.ads4699Google Scholar DOI PubMed

Rapid development and field evaluation of a portable CRISPR-based assay for Mpox during the 2025 Sierra Leone outbreak.

Gopal N, Abay T, Payne C, et al. Rapid development and field evaluation of a portable CRISPR-based assay for Mpox during the 2025 Sierra Leone outbreak. Nature communications. 2026. doi:10.1038/s41467-026-74034-8Google Scholar DOI PubMed

Unravelling bacterial complexity at high resolution with single-cell transcriptomics.

Clatworthy AE, DiNatale VP, Burgos-Robles E, Lopes F, Smillie C, Hung DT. Unravelling bacterial complexity at high resolution with single-cell transcriptomics. Nature microbiology. 2026. doi:10.1038/s41564-026-02333-3Google Scholar DOI PubMed

Large-Scale Chemical-Genetic Interaction Profiling Identifies a Small-Molecule Inhibitor of Mycobacterium tuberculosis Polyketide Synthase 13

Gomez JE, Solomon MY, Hunt DK, et al. Large-Scale Chemical-Genetic Interaction Profiling Identifies a Small-Molecule Inhibitor of Mycobacterium tuberculosis Polyketide Synthase 13. ACS infectious diseases. 2026. doi:10.1021/acsinfecdis.6c00136Google Scholar DOI PubMed

An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut.

Spiga L, Fansler RT, Wu Y, et al. An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut. Cell. 2026. doi:10.1016/j.cell.2026.04.012Google Scholar DOI PubMed

An infant nasal microbial gene atlas uncovers intervention-driven microbiome shifts and salt-resistant pathogen expansion.

Steinberg R, Pust MM, Arias-Rojas A, et al. An infant nasal microbial gene atlas uncovers intervention-driven microbiome shifts and salt-resistant pathogen expansion. Cell host & microbe. 2026. doi:10.1016/j.chom.2026.03.019Google Scholar DOI PubMed

Microbiota-mediated induction of beige adipocytes in response to dietary cues.

Tanoue T, Nagayama M, Roochana AJA, et al. Microbiota-mediated induction of beige adipocytes in response to dietary cues. Nature. 2026. doi:10.1038/s41586-026-10205-3Google Scholar DOI PubMed

Population genomics of Anopheles darlingi, the principal South American malaria vector mosquito.

Tennessen JA, Brosula R, Chabanol E, et al. Population genomics of Anopheles darlingi, the principal South American malaria vector mosquito. Science (New York, N.Y.). 2026;391(6792):1373-1378. doi:10.1126/science.adw9761Google Scholar DOI PubMed

Identifying microbial protease allergens through protein language model-guided homology.

Thurimella K, Wu E, Li C, et al. Identifying microbial protease allergens through protein language model-guided homology. Cell systems. 2026:101510. doi:10.1016/j.cels.2025.101510Google Scholar DOI PubMed

Coffee and Tea Intake, Dementia Risk, and Cognitive Function.

Zhang Y, Liu Y, Li Y, et al. Coffee and Tea Intake, Dementia Risk, and Cognitive Function. JAMA. 2026. doi:10.1001/jama.2025.27259Google Scholar DOI PubMed