Cardiovascular disease

A Bayesian framework for longitudinal EHR and genetic discovery.

Urbut SM, Ding Y, Nakao T, et al. A Bayesian framework for longitudinal EHR and genetic discovery. Nature. 2026. doi:10.1038/s41586-026-10780-5Google Scholar DOI PubMed

Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants.

Marston NA, Kany S, Melloni GEM, et al. Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants. Nature medicine. 2026. doi:10.1038/s41591-026-04439-xGoogle Scholar DOI PubMed

An integrated cell atlas of 2.4 million cardiac cells across 209 individuals in health and disease.

Datar Y, Chaffin M, Simonson B, Mandia A, Ellinor PT. An integrated cell atlas of 2.4 million cardiac cells across 209 individuals in health and disease. Nature cardiovascular research. 2026. doi:10.1038/s44161-026-00831-5Google Scholar DOI PubMed

Single Cell Analysis of Human Heart Failure With Preserved Ejection Fraction.

Hahn VS, Chaffin M, Simonson B, et al. Single Cell Analysis of Human Heart Failure With Preserved Ejection Fraction. Circulation research. 2026. doi:10.1161/CIRCRESAHA.125.327433Google Scholar DOI PubMed

Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations.

Koyama S, Yu Z, Choi SH, et al. Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations. Nature genetics. 2026. doi:10.1038/s41588-026-02613-yGoogle Scholar DOI PubMed

The Inherited Basis of Coronary Artery Disease

Schunkert H, Natarajan P, Samani NJ. The Inherited Basis of Coronary Artery Disease. New England Journal of Medicine. 2026;(394). doi:10.1056/NEJMra2405153Google Scholar DOI

Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions.

Misra A, Jowell A, Haidermota S, et al. Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions. Journal of the American College of Cardiology. 2026. doi:10.1016/j.jacc.2026.03.035Google Scholar DOI PubMed

Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum.

Hemeryck J, De Moor N, Ezzat D, et al. Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum. JAMA cardiology. 2026. doi:10.1001/jamacardio.2026.0363Google Scholar DOI PubMed

An integrated germline and somatic genomic model for coronary artery disease.

Yang X, Kim MS, Zhu X, et al. An integrated germline and somatic genomic model for coronary artery disease. Nature communications. 2026. doi:10.1038/s41467-026-70379-2Google Scholar DOI PubMed

Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice.

Yin X, Bickerton C, MacDonald B, et al. Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice. Liver international : official journal of the International Association for the Study of the Liver. 2026;46(2):e70507. doi:10.1111/liv.70507Google Scholar DOI PubMed