Obesity

Variant-to-function approaches for adipose tissue: Insights into cardiometabolic disorders.

Metz S, Belanich JR, Claussnitzer M, Kilpeläinen TO. Variant-to-function approaches for adipose tissue: Insights into cardiometabolic disorders. Cell genomics. 2025:100844. doi:10.1016/j.xgen.2025.100844Google Scholar DOI PubMed

Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data.

Costanzo MC, Akolkar B, Claussnitzer M, et al. Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data. Diabetes. 2025. doi:10.2337/db25-0042Google Scholar DOI PubMed

Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease.

Yoshiji S, Lu T, Butler-Laporte G, et al. Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease. Nature genetics. 2025. doi:10.1038/s41588-024-02052-7Google Scholar DOI PubMed

Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue.

Emont MP, Essene AL, Gulko A, et al. Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue. Molecular metabolism. 2025:102126. doi:10.1016/j.molmet.2025.102126Google Scholar DOI PubMed

Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.

Yan S, Santoro A, Niphakis MJ, et al. Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels. Nature communications. 2024;15(1):4605. doi:10.1038/s41467-024-48220-5Google Scholar DOI PubMed

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.

Holman CD, Sakers AP, Calhoun RP, et al. Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming. eLife. 2024;12. doi:10.7554/eLife.87756Google Scholar DOI PubMed

An integrative framework to prioritize genes in more than 500 loci associated with body mass index.

Hemerich D, Svenstrup V, Obrero VD, et al. An integrative framework to prioritize genes in more than 500 loci associated with body mass index. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.04.016Google Scholar DOI PubMed

Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice.

Lee J, Wellenstein K, Rahnavard A, et al. Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(28):e2318691121. doi:10.1073/pnas.2318691121Google Scholar DOI PubMed

Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood.

St Fleur RG, Tanofsky-Kraff M, Yanovski JA, et al. Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood. International journal of obesity (2005). 2024. doi:10.1038/s41366-024-01700-6Google Scholar DOI PubMed

Control of lipolysis by a population of oxytocinergic sympathetic neurons.

Li E, Wang L, Wang D, et al. Control of lipolysis by a population of oxytocinergic sympathetic neurons. Nature. 2024;625(7993):175-180. doi:10.1038/s41586-023-06830-xGoogle Scholar DOI PubMed