Brain Health, Psychiatric disease

Search for a genetic cause of variably protease-sensitive prionopathy.

Lian Y, Kotobelli K, Hall S, et al. Search for a genetic cause of variably protease-sensitive prionopathy. PLoS pathogens. 2025;21(8):e1013343. doi:10.1371/journal.ppat.1013343PubMed DOI Google Scholar

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus.

Mandell KAP, Simmons SK, Nadig A, et al. Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus. Translational psychiatry. 2025;15(1):345. doi:10.1038/s41398-025-03563-5PubMed DOI Google Scholar

Cassini: streamlined and scalable method for in situ profiling of RNA and protein.

Lapique N, Kim MT, Thom N, Nadaf NM, Pineda J, Macosko EZ. Cassini: streamlined and scalable method for in situ profiling of RNA and protein. Nature communications. 2025;16(1):8747. doi:10.1038/s41467-025-63798-0PubMed DOI Google Scholar

Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues using STARmap PLUS, RIBOmap and TEMPOmap.

Ren J, Zeng H, Huang J, et al. Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues using STARmap PLUS, RIBOmap and TEMPOmap. Nature protocols. 2025. doi:10.1038/s41596-025-01248-3PubMed DOI Google Scholar

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder.

Song BJ, Ge Y, Nicolella A, et al. Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder. Nature communications. 2025;16(1):10793. doi:10.1038/s41467-025-66504-2PubMed DOI Google Scholar

Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda.

Stevenson A, Akena D, Stroud RE, et al. Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda. BMJ Open. 2019;9(2):e025469. doi:10.1136/bmjopen-2018-025469PubMed DOI Google Scholar

Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.

Stein MB, Chen CY, Ursano RJ, et al. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry. 2016;73(7):695-704. doi:10.1001/jamapsychiatry.2016.0350PubMed DOI Google Scholar

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.

Han B, Pouget JG, Slowikowski K, et al. A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet. 2016;48(7):803-10. doi:10.1038/ng.3572PubMed DOI Google Scholar

Exome Sequencing of Familial Bipolar Disorder.

Goes FS, Pirooznia M, Parla JS, et al. Exome Sequencing of Familial Bipolar Disorder. JAMA Psychiatry. 2016;73(6):590-7. doi:10.1001/jamapsychiatry.2016.0251PubMed DOI Google Scholar

Adult axolotls can regenerate original neuronal diversity in response to brain injury.

Amamoto R, Huerta VGL, Takahashi E, et al. Adult axolotls can regenerate original neuronal diversity in response to brain injury. Elife. 2016;5. doi:10.7554/eLife.13998PubMed DOI Google Scholar