Cancer

Scaling computational genomics to millions of individuals with GPUs.

Taylor-Weiner A, Aguet F, Haradhvala NJ, et al. Scaling computational genomics to millions of individuals with GPUs. Genome Biol. 2019;20(1):228. doi:10.1186/s13059-019-1836-7PubMed DOI Google Scholar

A nuclease-polymerase chain reaction enables amplification of probes used for capture-based DNA target enrichment.

Leong KW, Yu F, Adalsteinsson VA, et al. A nuclease-polymerase chain reaction enables amplification of probes used for capture-based DNA target enrichment. Nucleic Acids Res. 2019. doi:10.1093/nar/gkz870PubMed DOI Google Scholar

Passenger Hotspot Mutations in Cancer.

Hess JM, Bernards A, Kim J, et al. Passenger Hotspot Mutations in Cancer. Cancer Cell. 2019;36(3):288-301.e14. doi:10.1016/j.ccell.2019.08.002PubMed DOI Google Scholar

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

Parikh AR, Leshchiner I, Elagina L, et al. Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019;25(9):1415-1421. doi:10.1038/s41591-019-0561-9PubMed DOI Google Scholar

Finding the edge of the seat.

Van Allen EM. Finding the edge of the seat. Nat Med. 2019;25(9):1328. doi:10.1038/s41591-019-0557-5PubMed DOI Google Scholar

CHIPing away at breast cancer.

Sperling AS, Ebert BL. CHIPing away at breast cancer. J Natl Cancer Inst. 2019. doi:10.1093/jnci/djz158PubMed DOI Google Scholar

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.

Reitman ZJ, Paolella BR, Bergthold G, et al. Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells. Nat Commun. 2019;10(1):3731. doi:10.1038/s41467-019-11493-2PubMed DOI Google Scholar

A dominant-negative effect drives selection of missense mutations in myeloid malignancies.

Boettcher S, Miller PG, Sharma R, et al. A dominant-negative effect drives selection of missense mutations in myeloid malignancies. Science. 2019;365(6453):599-604. doi:10.1126/science.aax3649PubMed DOI Google Scholar

Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma.

Sethi N, Kikuchi O, McFarland J, et al. Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma. JCI Insight. 2019;4(15). doi:10.1172/jci.insight.128439PubMed DOI Google Scholar

Towards Immunotherapy for Pediatric Brain Tumors.

Wang SS, Bandopadhayay P, Jenkins MR. Towards Immunotherapy for Pediatric Brain Tumors. Trends Immunol. 2019;40(8):748-761. doi:10.1016/j.it.2019.05.009PubMed DOI Google Scholar