Stanley Center for Psychiatric Research
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome. Sci Transl Med. 2020;12(544). doi:10.1126/scitranslmed.aam8572.
Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits. Transl Psychiatry. 2020;10(1):29. doi:10.1038/s41398-020-0685-1.
Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes. Nat Commun. 2019;10(1):4377. doi:10.1038/s41467-019-12372-6.
Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution. Science. 2019;363(6434):1463-1467. doi:10.1126/science.aaw1219.
. Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder. J Psychiatry Neurosci. 2019;44(2):120-131. doi:10.1503/jpn.180032.
Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda. BMJ Open. 2019;9(2):e025469. doi:10.1136/bmjopen-2018-025469.
Clinical implications of the proposed ICD-11 PTSD diagnostic criteria. Psychol Med. 2019;49(3):483-490. doi:10.1017/S0033291718001101.
Amygdalar activity predicts future incident diabetes independently of adiposity. Psychoneuroendocrinology. 2019;100:32-40. doi:10.1016/j.psyneuen.2018.09.024.
Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland. Nat Commun. 2019;10(1):410. doi:10.1038/s41467-018-08262-y.
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity. 2019;50(1):253-271.e6. doi:10.1016/j.immuni.2018.11.004.
The NeuroDev Study: Phenotypic and Genetic Characterization of Neurodevelopmental Disorders in Kenya and South Africa. Neuron. 2019;101(1):15-19. doi:10.1016/j.neuron.2018.12.016.
Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia. Am J Psychiatry. 2019;176(1):29-35. doi:10.1176/appi.ajp.2018.17040467.
Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls - CORRIGENDUM. Psychol Med. 2019;49(2):351. doi:10.1017/S0033291718002945.
Reply to 'Selective effects of heterozygous protein-truncating variants'. Nat Genet. 2019;51(1):3-4. doi:10.1038/s41588-018-0301-y.
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet. 2019;51(1):63-75. doi:10.1038/s41588-018-0269-7.
Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice. Biol Psychiatry. 2018;84(12):917-925. doi:10.1016/j.biopsych.2018.05.011.
Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder. Science. 2018;362(6420). doi:10.1126/science.aat6576.
. The ethics of global psychiatric genomics: Multilayered challenges to integrating genomics in global mental health and disability-A position paper of the Oxford Global Initiative in Neuropsychiatric GenEthics (NeuroGenE). Am J Med Genet B Neuropsychiatr Genet. 2018. doi:10.1002/ajmg.b.32697.
. Associations between childhood maltreatment and risk of myocardial infarction in adulthood: Results from the National Epidemiologic Survey on alcohol and Related Conditions. J Psychiatr Res. 2018. doi:10.1016/j.jpsychires.2018.12.001.
Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder. Epigenomics. 2018;10(12):1585-1601. doi:10.2217/epi-2018-0049.
Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018;136(6):857-872. doi:10.1007/s00401-018-1881-4.
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018;21(12):1656-1669. doi:10.1038/s41593-018-0275-1.
Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement. 2018;14(12):1580-1588. doi:10.1016/j.jalz.2018.01.017.
. The critical needs and challenges for genetic architecture studies in Africa. Curr Opin Genet Dev. 2018;53:113-120. doi:10.1016/j.gde.2018.08.005.
Posttraumatic stress disorder and incidence of thyroid dysfunction in women. Psychol Med. 2018:1-10. doi:10.1017/S0033291718003495.
. Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice. Sci Rep. 2018;8(1):17293. doi:10.1038/s41598-018-35716-6.
Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons. Development. 2018;145(22). doi:10.1242/dev.168617.
. Aggregated SOD1 causes selective death of cultured human motor neurons. Sci Rep. 2018;8(1):16393. doi:10.1038/s41598-018-34759-z.
Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations. Nat Genet. 2018;50(11):1600-1607. doi:10.1038/s41588-018-0231-8.
Guideline-based and bioinformatic reassessment of lesion-associated gene and variant pathogenicity in focal human epilepsies. Epilepsia. 2018;59(11):2145-2152. doi:10.1111/epi.14579.
Phenome-wide association studies across large population cohorts support drug target validation. Nat Commun. 2018;9(1):4285. doi:10.1038/s41467-018-06540-3.
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. Neuron. 2018;100(1):120-134.e6. doi:10.1016/j.neuron.2018.09.017.
. Microglia and the Brain: Complementary Partners in Development and Disease. Annu Rev Cell Dev Biol. 2018;34:523-544. doi:10.1146/annurev-cellbio-100616-060509.
Posttraumatic stress disorder and development of premenstrual syndrome in a longitudinal cohort of women. Arch Womens Ment Health. 2018. doi:10.1007/s00737-018-0916-0.
Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects. Nat Commun. 2018;9(1):4038. doi:10.1038/s41467-018-06159-4.
. New tricks for an ancient system: Physiological and pathological roles of complement in the CNS. Mol Immunol. 2018;102:3-13. doi:10.1016/j.molimm.2018.06.264.
Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018). Twin Res Hum Genet. 2018;21(5):394-397. doi:10.1017/thg.2018.46.
. Gene therapy for neurological disorders: progress and prospects. Nat Rev Drug Discov. 2018;17(10):767. doi:10.1038/nrd.2018.158.
Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol. 2018;217(10):3747-3765. doi:10.1083/jcb.201802057.
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk.
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk. Nat Genet. 2018;50(10):1483-1493. doi:10.1038/s41588-018-0196-7.
The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families. Cephalalgia. 2018;38(12):1849-1863. doi:10.1177/0333102418761041.
Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis. Transl Psychiatry. 2018;8(1):204. doi:10.1038/s41398-018-0229-0.
De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis. Cell Rep. 2018;24(13):3441-3454.e12. doi:10.1016/j.celrep.2018.08.082.
Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychol Med. 2018:1-8. doi:10.1017/S0033291718002039.
. Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells. Proc Natl Acad Sci U S A. 2018;115(36):E8368-E8377. doi:10.1073/pnas.1802568115.
Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study. Lancet Neurol. 2018;17(9):773-781. doi:10.1016/S1474-4422(18)30251-5.
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol Psychiatry. 2018. doi:10.1038/s41380-018-0112-7.
Genetic Influences on Patient-Oriented Outcomes in Traumatic Brain Injury: A Living Systematic Review of Non-Apolipoprotein E Single-Nucleotide Polymorphisms. J Neurotrauma. 2018. doi:10.1089/neu.2017.5583.
Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain. Cell. 2018;174(4):1015-1030.e16. doi:10.1016/j.cell.2018.07.028.
Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum. J Physiol. 2018;596(16):3695-3707. doi:10.1113/JP275936.
Rare coding variants in genes encoding GABA receptors in genetic generalised epilepsies: an exome-based case-control study. Lancet Neurol. 2018;17(8):699-708. doi:10.1016/S1474-4422(18)30215-1.
Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol. 2018;75(8):989-998. doi:10.1001/jamaneurol.2018.0821.
. Developing neurons are innately inclined to learn on the job. Nature. 2018;560(7716):39-40. doi:10.1038/d41586-018-05737-2.
Molecular genetic overlap between migraine and major depressive disorder. Eur J Hum Genet. 2018;26(8):1202-1216. doi:10.1038/s41431-018-0150-2.
A synthetic-diploid benchmark for accurate variant-calling evaluation. Nat Methods. 2018;15(8):595-597. doi:10.1038/s41592-018-0054-7.
. Genetics Sheds New Light on Congenital Hydrocephalus Biology. Neuron. 2018;99(2):246-247. doi:10.1016/j.neuron.2018.07.008.
Layer I Interneurons Sharpen Sensory Maps during Neonatal Development. Neuron. 2018;99(1):98-116.e7. doi:10.1016/j.neuron.2018.06.002.
Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function. Mol Psychiatry. 2018. doi:10.1038/s41380-018-0113-6.
. Viral Strategies for Targeting the Central and Peripheral Nervous Systems. Annu Rev Neurosci. 2018;41:323-348. doi:10.1146/annurev-neuro-080317-062048.
Toward Precision Medicine for Neurological and Neuropsychiatric Disorders. Cell Stem Cell. 2018;23(1):21-24. doi:10.1016/j.stem.2018.05.019.
. Age at first birth in women is genetically associated with increased risk of schizophrenia. Sci Rep. 2018;8(1):10168. doi:10.1038/s41598-018-28160-z.
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun. 2018;6(1):55. doi:10.1186/s40478-018-0555-8.
. Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry. 2018;57(26):3916-3924. doi:10.1021/acs.biochem.8b00367.
Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. J Clin Invest. 2018;128(7):3008-3023. doi:10.1172/JCI95231.
Prevalence of rearrangements in the 22q11.2 region and population-based risk of neuropsychiatric and developmental disorders in a Danish population: a case-cohort study. Lancet Psychiatry. 2018;5(7):573-580. doi:10.1016/S2215-0366(18)30168-8.
Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. Nat Genet. 2018;50(7):1041-1047. doi:10.1038/s41588-018-0148-2.
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes Dev. 2018;32(13-14):929-943. doi:10.1101/gad.313932.118.
Progress in Understanding and Treating SCN2A-Mediated Disorders. Trends Neurosci. 2018;41(7):442-456. doi:10.1016/j.tins.2018.03.011.
. Depressive Symptoms, Antidepressant Use, and Hypertension in Young Adulthood. Epidemiology. 2018;29(4):547-555. doi:10.1097/EDE.0000000000000840.
Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotides. Genome Res. 2018;28(7):968-974. doi:10.1101/gr.231902.117.
GeNets: a unified web platform for network-based genomic analyses. Nat Methods. 2018;15(7):543-546. doi:10.1038/s41592-018-0039-6.
Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons. Nat Biomed Eng. 2018;2(7):540-554. doi:10.1038/s41551-018-0219-9.
De novo variants in neurodevelopmental disorders with epilepsy. Nat Genet. 2018;50(7):1048-1053. doi:10.1038/s41588-018-0143-7.
Types of Trauma, Posttraumatic Stress Disorder, and Academic Performance in a Population of University Students. J Nerv Ment Dis. 2018;206(7):507-512. doi:10.1097/NMD.0000000000000842.
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet. 2018;50(7):937-943. doi:10.1038/s41588-018-0155-3.
Comprehensive comparative analysis of 5'-end RNA-sequencing methods. Nat Methods. 2018;15(7):505-511. doi:10.1038/s41592-018-0014-2.
Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations. Nature. 2018;559(7714):350-355. doi:10.1038/s41586-018-0321-x.
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet. 2018;50(7):912-919. doi:10.1038/s41588-018-0152-6.
. Mixed-model association for biobank-scale datasets. Nat Genet. 2018;50(7):906-908. doi:10.1038/s41588-018-0144-6.
. Childhood interpersonal violence and adult alcohol, cannabis, and tobacco use disorders: variation by race/ethnicity?. Psychol Med. 2018;48(9):1540-1550. doi:10.1017/S0033291717003208.
The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection. Cell. 2018;174(1):44-58.e17. doi:10.1016/j.cell.2018.04.019.
Analysis of shared heritability in common disorders of the brain. Science. 2018;360(6395). doi:10.1126/science.aap8757.
A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry. 2018;83(12):1044-1053. doi:10.1016/j.biopsych.2017.11.026.
Cell. 2018;173(7):1705-1715.e16. doi:10.1016/j.cell.2018.05.046.
Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum. Am J Hum Genet. 2018;102(6):1204-1211. doi:10.1016/j.ajhg.2018.05.002.
. Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood. Am J Hum Genet. 2018;102(6):1185-1194. doi:10.1016/j.ajhg.2018.03.021.
Traumatic stress and accelerated DNA methylation age: A meta-analysis. Psychoneuroendocrinology. 2018;92:123-134. doi:10.1016/j.psyneuen.2017.12.007.
A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease. Nat Neurosci. 2018;21(6):811-819. doi:10.1038/s41593-018-0154-9.
Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Elife. 2018;7. doi:10.7554/eLife.33385.
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Rep. 2018;23(8):2509-2523. doi:10.1016/j.celrep.2018.04.066.
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Cell. 2018;173(5):1265-1279.e19. doi:10.1016/j.cell.2018.03.037.
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron. 2018;98(4):743-753.e4. doi:10.1016/j.neuron.2018.04.014.
Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland. Am J Hum Genet. 2018;102(5):760-775. doi:10.1016/j.ajhg.2018.03.003.
Distinguishing postpartum and antepartum depressive trajectories in a large population-based cohort: the impact of exposure to adversity and offspring gender. Psychol Med. 2018;48(7):1139-1147. doi:10.1017/S0033291717002549.
. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(5):693-698. doi:10.1038/s41588-018-0099-7.
Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits. Nat Genet. 2018;50(5):737-745. doi:10.1038/s41588-018-0108-x.
Early Risk and Resiliency Factors Predict Chronic Posttraumatic Stress Disorder in Caregivers of Patients Admitted to a Neuroscience ICU. Crit Care Med. 2018;46(5):713-719. doi:10.1097/CCM.0000000000002988.
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa. Mol Psychiatry. 2018;23(5):1169-1180. doi:10.1038/mp.2017.88.
An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder. Nat Genet. 2018;50(5):727-736. doi:10.1038/s41588-018-0107-y.
Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study.
Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study. Nat Commun. 2018;9(1):1612. doi:10.1038/s41467-018-03910-9.
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment. ACS Chem Biol. 2018;13(4):1038-1047. doi:10.1021/acschembio.8b00168.
Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Mol Cell. 2018;70(2):211-227.e8. doi:10.1016/j.molcel.2018.03.012.
In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images. Cell. 2018;173(3):792-803.e19. doi:10.1016/j.cell.2018.03.040.
. Thalamic Reticular Dysfunction as a Circuit Endophenotype in Neurodevelopmental Disorders. Neuron. 2018;98(2):282-295. doi:10.1016/j.neuron.2018.03.021.
. A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors. ACS Chem Neurosci. 2018;9(4):684-690. doi:10.1021/acschemneuro.7b00485.
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nat Genet. 2018;50(4):621-629. doi:10.1038/s41588-018-0081-4.
The ethics of experimenting with human brain tissue. Nature. 2018;556(7702):429-432. doi:10.1038/d41586-018-04813-x.
Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nat Genet. 2018;50(4):538-548. doi:10.1038/s41588-018-0092-1.
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters. Nat Chem Biol. 2018;14(4):352-360. doi:10.1038/s41589-018-0004-9.
Developmental diversification of cortical inhibitory interneurons. Nature. 2018;555(7697):457-462. doi:10.1038/nature25999.
Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice. Neuron. 2018;97(6):1394. doi:10.1016/j.neuron.2018.03.006.
Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins. Cell Rep. 2018;22(12):3351-3361. doi:10.1016/j.celrep.2018.02.081.
Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers. Sci Rep. 2018;8(1):4467. doi:10.1038/s41598-018-22790-z.
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018;10(431). doi:10.1126/scitranslmed.aam8460.
Posttraumatic stress disorder onset and inflammatory and endothelial function biomarkers in women. Brain Behav Immun. 2018;69:203-209. doi:10.1016/j.bbi.2017.11.013.
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Mol Psychiatry. 2018;23(3):666-673. doi:10.1038/mp.2017.77.
Advancing neuropsychiatric genetics training and collaboration in Africa. Lancet Glob Health. 2018;6(3):e246-e247. doi:10.1016/S2214-109X(18)30042-1.
Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data. Elife. 2018;7. doi:10.7554/eLife.28728.
Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism. Cell Rep. 2018;22(7):1695-1709. doi:10.1016/j.celrep.2018.01.007.
Recovery from DSM-IV post-traumatic stress disorder in the WHO World Mental Health surveys. Psychol Med. 2018;48(3):437-450. doi:10.1017/S0033291717001817.
Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study. Cephalalgia. 2018;38(2):312-322. doi:10.1177/0333102417690111.
. Windows of opportunity: timing in neurodevelopmental disorders. Curr Opin Neurobiol. 2018;48:59-63. doi:10.1016/j.conb.2017.10.014.
ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties. Mol Psychiatry. 2018;23(2):263-270. doi:10.1038/mp.2016.198.
Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat Genet. 2018;50(2):229-237. doi:10.1038/s41588-017-0009-4.
. Using intracellular markers to identify a novel set of surface markers for live cell purification from a heterogeneous hIPSC culture. Sci Rep. 2018;8(1):804. doi:10.1038/s41598-018-19291-4.
. The Intergenerational Impact of Prenatal Stress: Time to Focus on Prevention?. Biol Psychiatry. 2018;83(2):92-93. doi:10.1016/j.biopsych.2017.11.004.
Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon. Development. 2018;145(1). doi:10.1242/dev.154583.
. Organoids required! A new path to understanding human brain development and disease. Nat Methods. 2018;15(1):27-29. doi:10.1038/nmeth.4557.
. Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease. Curr Top Dev Biol. 2018;129:99-122. doi:10.1016/bs.ctdb.2018.03.002.
. Analyzing Copy Number Variation with Droplet Digital PCR. Methods Mol Biol. 2018;1768:143-160. doi:10.1007/978-1-4939-7778-9_9.
Using Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration. eNeuro. 2018;5(3). doi:10.1523/ENEURO.0001-18.2018.
Reproductive period and epigenetic modifications of the oxidative phosphorylation pathway in the human prefrontal cortex. PLoS One. 2018;13(7):e0199073. doi:10.1371/journal.pone.0199073.
. Functional Topography and Development of Inhibitory Reticulothalamic Barreloid Projections. Front Neuroanat. 2018;12:87. doi:10.3389/fnana.2018.00087.
. Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes. Methods Mol Biol. 2018;1787:235-252. doi:10.1007/978-1-4939-7847-2_18.
NetSig: network-based discovery from cancer genomes. Nat Methods. 2018;15(1):61-66. doi:10.1038/nmeth.4514.
Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat Neurosci. 2018;21(1):120-129. doi:10.1038/s41593-017-0029-5.
Post-traumatic stress disorder associated with sexual assault among women in the WHO World Mental Health Surveys. Psychol Med. 2018;48(1):155-167. doi:10.1017/S0033291717001593.
. Report on the National Eye Institute's Audacious Goals Initiative: Creating a Cellular Environment for Neuroregeneration. eNeuro. 2018;5(2). doi:10.1523/ENEURO.0035-18.2018.
. Using Droplet Digital PCR to Analyze Allele-Specific RNA Expression. Methods Mol Biol. 2018;1768:401-422. doi:10.1007/978-1-4939-7778-9_23.
. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Mol Neurobiol. 2017;54(10):8090-8109. doi:10.1007/s12035-016-0261-0.
A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017;216(11):3655-3675. doi:10.1083/jcb.201705085.
. Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1. J Neurosci. 2017;37(44):10541-10553. doi:10.1523/JNEUROSCI.2679-16.2017.
RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114(41):E8788-E8797. doi:10.1073/pnas.1714175114.
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017;13(10):1102-1108. doi:10.1038/nchembio.2458.
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017;357(6356):1156-1160. doi:10.1126/science.aah5043.
Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease. J Neurosci. 2017;37(37):9037-9053. doi:10.1523/JNEUROSCI.0811-17.2017.
. Microglia emerge as central players in brain disease. Nat Med. 2017;23(9):1018-1027. doi:10.1038/nm.4397.
Reconstructing cell cycle and disease progression using deep learning. Nat Commun. 2017;8(1):463. doi:10.1038/s41467-017-00623-3.
Data-analysis strategies for image-based cell profiling. Nat Methods. 2017;14(9):849-863. doi:10.1038/nmeth.4397.
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem Cell Reports. 2017;9(2):667-680. doi:10.1016/j.stemcr.2017.06.008.
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2017;22(8):1223. doi:10.1038/mp.2016.246.
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