You are here

Home » Publications

Stanley Center for Psychiatric Research

Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.
Porter NJ, Wagner FF, Christianson DW. Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry. 2018;57(26):3916-3924. doi:10.1021/acs.biochem.8b00367.
Progress in Understanding and Treating SCN2A-Mediated Disorders.
Sanders SJ, Campbell AJ, Cottrell JR, et al. Progress in Understanding and Treating SCN2A-Mediated Disorders. Trends Neurosci. 2018;41(7):442-456. doi:10.1016/j.tins.2018.03.011.
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.
Weïwer M, Xu Q, Gale JP, et al. Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment. ACS Chem Biol. 2018;13(4):1038-1047. doi:10.1021/acschembio.8b00168.
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Wagner FF, Benajiba L, Campbell AJ, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018;10(431). doi:10.1126/scitranslmed.aam8460.
Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes.
Pan JQ, Baez-Nieto D, Allen A, Wang H-R, Cottrell JR. Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes. Methods Mol Biol. 2018;1787:235-252. doi:10.1007/978-1-4939-7847-2_18.
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.
Lenihan JA, Saha O, Heimer-McGinn V, Cryan JF, Feng G, Young PW. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Mol Neurobiol. 2017;54(10):8090-8109. doi:10.1007/s12035-016-0261-0.
A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.
Feinberg K, Kolaj A, Wu C, et al. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017;216(11):3655-3675. doi:10.1083/jcb.201705085.
Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1.
Schecter RW, Maher EE, Welsh CA, Stevens B, Erisir A, Bear MF. Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1. J Neurosci. 2017;37(44):10541-10553. doi:10.1523/JNEUROSCI.2679-16.2017.
RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.
Ofengeim D, Mazzitelli S, Ito Y, et al. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114(41):E8788-E8797. doi:10.1073/pnas.1714175114.
Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease.
Kim J, Hughes EG, Shetty AS, et al. Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease. J Neurosci. 2017;37(37):9037-9053. doi:10.1523/JNEUROSCI.0811-17.2017.
Microglia emerge as central players in brain disease.
Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med. 2017;23(9):1018-1027. doi:10.1038/nm.4397.
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Tripathi P, Rodriguez-Muela N, Klim JR, et al. Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem Cell Reports. 2017;9(2):667-680. doi:10.1016/j.stemcr.2017.06.008.
Animal models for neuropsychiatric disorders: prospects for circuit intervention.
Kaiser T, Zhou Y, Feng G. Animal models for neuropsychiatric disorders: prospects for circuit intervention. Curr Opin Neurobiol. 2017;45:59-65. doi:10.1016/j.conb.2017.03.010.
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.
Song J, Bergen SE, Di Florio A, et al. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2017;22(8):1223. doi:10.1038/mp.2016.246.
InDrops and Drop-seq technologies for single-cell sequencing.
Klein AM, Macosko E. InDrops and Drop-seq technologies for single-cell sequencing. Lab Chip. 2017;17(15):2540-2541. doi:10.1039/c7lc90070h.
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.
Andrews PW, Ben-David U, Benvenisty N, et al. Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem Cell Reports. 2017;9(1):1-4. doi:10.1016/j.stemcr.2017.05.029.
The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression.
Lammert DB, Middleton FA, Pan J, Olson EC, Howell BW. The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression. J Neurochem. 2017;142(1):89-102. doi:10.1111/jnc.14045.
Addendum: A viral strategy for targeting and manipulating interneurons across vertebrate species.
Dimidschstein J, Chen Q, Tremblay R, et al. Addendum: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2017;20(7):1033. doi:10.1038/nn0717-1033d.
Corrigendum: A viral strategy for targeting and manipulating interneurons across vertebrate species.
Dimidschstein J, Chen Q, Tremblay R, et al. Corrigendum: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2017;20(7):1033. doi:10.1038/nn0717-1033c.
Corrigendum: Opportunities and challenges in modeling human brain disorders in transgenic primates.
Jennings C, Landman R, Zhou Y, et al. Corrigendum: Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci. 2017;20(7):1033. doi:10.1038/nn0717-1033b.
Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource.
Purcell SM, Manoach DS, Demanuele C, et al. Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource. Nat Commun. 2017;8:15930. doi:10.1038/ncomms15930.
Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases.
Palomo V, Perez DI, Roca C, et al. Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. J Med Chem. 2017;60(12):4983-5001. doi:10.1021/acs.jmedchem.7b00395.
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.
Shi Q, Chowdhury S, Ma R, et al. Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017;9(392). doi:10.1126/scitranslmed.aaf6295.
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Merkle FT, Ghosh S, Kamitaki N, et al. Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature. 2017;545(7653):229-233. doi:10.1038/nature22312.
Cell diversity and network dynamics in photosensitive human brain organoids.
Quadrato G, Nguyen T, Macosko EZ, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545(7652):48-53. doi:10.1038/nature22047.
Genetic and activity-dependent mechanisms underlying interneuron diversity.
Wamsley B, Fishell G. Genetic and activity-dependent mechanisms underlying interneuron diversity. Nat Rev Neurosci. 2017;18(5):299-309. doi:10.1038/nrn.2017.30.
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.
Wang W, Li C, Chen Q, et al. Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism. J Clin Invest. 2017;127(5):1978-1990. doi:10.1172/JCI87997.
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.
Platt RJ, Zhou Y, Slaymaker IM, et al. Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. Cell Rep. 2017;19(2):335-350. doi:10.1016/j.celrep.2017.03.052.
Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia.
Wallace ML, Saunders A, Huang KWui, et al. Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia. Neuron. 2017;94(1):138-152.e5. doi:10.1016/j.neuron.2017.03.017.
Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.
Schuetze KB, Stratton MS, Blakeslee WW, et al. Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts. J Pharmacol Exp Ther. 2017;361(1):140-150. doi:10.1124/jpet.116.237701.
The Path to New Therapies for Schizophrenia and Bipolar Illness.
Scolnick EM. The Path to New Therapies for Schizophrenia and Bipolar Illness. FASEB J. 2017;31(4):1254-1259. doi:10.1096/fj.201700028.
A molecular census of arcuate hypothalamus and median eminence cell types.
Campbell JN, Macosko EZ, Fenselau H, et al. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017;20(3):484-496. doi:10.1038/nn.4495.
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.
Kim MJ, Biag J, Fass DM, et al. Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. Mol Psychiatry. 2017;22(3):417-429. doi:10.1038/mp.2016.98.
SHANK proteins: roles at the synapse and in autism spectrum disorder.
Monteiro P, Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder. Nat Rev Neurosci. 2017;18(3):147-157. doi:10.1038/nrn.2016.183.
Comparative Analysis Highlights Variable Genome Content of Wheat Rusts and Divergence of the Mating Loci.
Cuomo CA, Bakkeren G, Khalil HBadr, et al. Comparative Analysis Highlights Variable Genome Content of Wheat Rusts and Divergence of the Mating Loci. G3 (Bethesda). 2017;7(2):361-376. doi:10.1534/g3.116.032797.
Studying human disease using human neurons.
Ahfeldt T, Litterman NK, Rubin LL. Studying human disease using human neurons. Brain Res. 2017;1656:40-48. doi:10.1016/j.brainres.2016.03.051.
Editorial overview: Developmental neuroscience 2017.
Arlotta P, Vanderhaeghen P. Editorial overview: Developmental neuroscience 2017. Curr Opin Neurobiol. 2017;42:A1-A4. doi:10.1016/j.conb.2017.01.003.
Neurotoxic reactive astrocytes are induced by activated microglia.
Liddelow SA, Guttenplan KA, Clarke LE, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541(7638):481-487. doi:10.1038/nature21029.
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.
Marshall CR, Howrigan DP, Merico D, et al. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat Genet. 2017;49(1):27-35. doi:10.1038/ng.3725.
Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function.
Hong S, Wilton DK, Stevens B, Richardson DS. Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function. Methods Mol Biol. 2017;1538:155-167. doi:10.1007/978-1-4939-6688-2_12.
A scored human protein-protein interaction network to catalyze genomic interpretation.
Li T, Wernersson R, Hansen RB, et al. A scored human protein-protein interaction network to catalyze genomic interpretation. Nat Methods. 2017;14(1):61-64. doi:10.1038/nmeth.4083.
A viral strategy for targeting and manipulating interneurons across vertebrate species.
Dimidschstein J, Chen Q, Tremblay R, et al. A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2016;19(12):1743-1749. doi:10.1038/nn.4430.
Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection.
Wells MF, Salick MR, Wiskow O, et al. Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection. Cell Stem Cell. 2016;19(6):703-708. doi:10.1016/j.stem.2016.11.011.
Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome.
Hamilton EP, Kapusta A, Huvos PE, et al. Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome. Elife. 2016;5. doi:10.7554/eLife.19090.
Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome.
Banerjee A, Rikhye RV, Breton-Provencher V, et al. Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome. Proc Natl Acad Sci U S A. 2016;113(46):E7287-E7296. doi:10.1073/pnas.1615330113.
Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.
Wang L, Brooks AN, Fan J, et al. Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia. Cancer Cell. 2016;30(5):750-763. doi:10.1016/j.ccell.2016.10.005.
Balancing selection shapes density-dependent foraging behaviour.
Greene JS, Brown M, Dobosiewicz M, et al. Balancing selection shapes density-dependent foraging behaviour. Nature. 2016;539(7628):254-258. doi:10.1038/nature19848.
Increasing the neurological-disease toolbox using iPSC-derived microglia.
Hammond TR, Stevens B. Increasing the neurological-disease toolbox using iPSC-derived microglia. Nat Med. 2016;22(11):1206-1207. doi:10.1038/nm.4226.
The promises and challenges of human brain organoids as models of neuropsychiatric disease.
Quadrato G, Brown J, Arlotta P. The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat Med. 2016;22(11):1220-1228. doi:10.1038/nm.4214.
Back to basics: luring industry back into neuroscience.
Hyman SE. Back to basics: luring industry back into neuroscience. Nat Neurosci. 2016;19(11):1383-1384. doi:10.1038/nn.4429.
Research Into Brain Disorders as an Example of Targeted Science.
Hyman SE, Landis SC, Leshner AI. Research Into Brain Disorders as an Example of Targeted Science. JAMA. 2016;316(16):1673-1674. doi:10.1001/jama.2016.12412.
A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity.
Andrade A, Hope J, Allen A, Yorgan V, Lipscombe D, Pan JQ. A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity. Sci Rep. 2016;6:34233. doi:10.1038/srep34233.
Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding.
Chen N, Sugihara H, Kim J, et al. Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding. Elife. 2016;5. doi:10.7554/eLife.18716.
Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?
Manoach DS, Pan JQ, Purcell SM, Stickgold R. Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?. Biol Psychiatry. 2016;80(8):599-608. doi:10.1016/j.biopsych.2015.10.003.
Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.
Coleman JJ, Komura T, Munro J, et al. Activity of caffeic acid phenethyl ester in Caenorhabditis elegans. Future Med Chem. 2016. doi:10.4155/fmc-2016-0085.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Wagner FF, Weïwer M, Steinbacher S, et al. Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg Med Chem. 2016;24(18):4008-4015. doi:10.1016/j.bmc.2016.06.040.
Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9.
Herring A, Messana A, Bara AM, Hazelbaker DZ, Eggan K, Barrett LE. Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Res. 2016;17(2):430-432. doi:10.1016/j.scr.2016.09.009.
Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9.
Bara AM, Messana A, Herring A, Hazelbaker DZ, Eggan K, Barrett LE. Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Res. 2016;17(2):441-443. doi:10.1016/j.scr.2016.09.008.
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.
Song J, Bergen SE, Di Florio A, et al. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2016;21(9):1290-7. doi:10.1038/mp.2015.165.
Opportunities and challenges in modeling human brain disorders in transgenic primates.
Jennings CG, Landman R, Zhou Y, et al. Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci. 2016;19(9):1123-30. doi:10.1038/nn.4362.
Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics.
Shekhar K, Lapan SW, Whitney IE, et al. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016;166(5):1308-1323.e30. doi:10.1016/j.cell.2016.07.054.
Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.
Loh KH, Stawski PS, Draycott AS, et al. Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Cell. 2016;166(5):1295-1307.e21. doi:10.1016/j.cell.2016.07.041.
Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells.
Santos DP, Kiskinis E, Eggan K, Merkle FT. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2016;38:5B.6.1-5B.6.60. doi:10.1002/cpsc.15.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Liang SH, Chen JMichael, Normandin MD, et al. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016;55(33):9601-5. doi:10.1002/anie.201603797.
Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons.
Zhao B, Zhu J, Dai D, et al. Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons. Neuropharmacology. 2016;107:396-410. doi:10.1016/j.neuropharm.2016.03.037.
Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression.
Schafer DP, Heller CT, Gunner G, et al. Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife. 2016;5. doi:10.7554/eLife.15224.
Microglia: Phagocytosing to Clear, Sculpt, and Eliminate.
Hong S, Stevens B. Microglia: Phagocytosing to Clear, Sculpt, and Eliminate. Dev Cell. 2016;38(2):126-8. doi:10.1016/j.devcel.2016.07.006.
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.
Wagner FF, Bishop JA, Gale JP, et al. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 2016;11(7):1952-63. doi:10.1021/acschembio.6b00306.
Unbiased Deep Sequencing of RNA Viruses from Clinical Samples.
Matranga CB, Gladden-Young A, Qu J, et al. Unbiased Deep Sequencing of RNA Viruses from Clinical Samples. J Vis Exp. 2016;(113). doi:10.3791/54117.
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.
Han B, Pouget JG, Slowikowski K, et al. A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet. 2016;48(7):803-10. doi:10.1038/ng.3572.
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.
Stein MB, Chen C-Y, Ursano RJ, et al. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry. 2016;73(7):695-704. doi:10.1001/jamapsychiatry.2016.0350.
A complement-microglial axis drives synapse loss during virus-induced memory impairment.
Vasek MJ, Garber C, Dorsey D, et al. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016;534(7608):538-43. doi:10.1038/nature18283.
Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System.
Rigamonti A, Repetti GG, Sun C, et al. Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System. Stem Cell Reports. 2016;6(6):993-1008. doi:10.1016/j.stemcr.2016.05.010.
Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures.
Lu Y, Zhong C, Wang L, et al. Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nat Commun. 2016;7:12019. doi:10.1038/ncomms12019.
Exome Sequencing of Familial Bipolar Disorder.
Goes FS, Pirooznia M, Parla JS, et al. Exome Sequencing of Familial Bipolar Disorder. JAMA Psychiatry. 2016;73(6):590-7. doi:10.1001/jamapsychiatry.2016.0251.
Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers.
Berglund K, Wen L, Dunbar RL, Feng G, Augustine GJ. Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers. J Neurosci. 2016;36(21):5709-23. doi:10.1523/JNEUROSCI.4366-15.2016.
Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies.
Ma Y, Li J, Wang G, et al. Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies. Sci Rep. 2016;6:25888. doi:10.1038/srep25888.
Adult axolotls can regenerate original neuronal diversity in response to brain injury.
Amamoto R, Huerta VGisselle L, Takahashi E, et al. Adult axolotls can regenerate original neuronal diversity in response to brain injury. Elife. 2016;5. doi:10.7554/eLife.13998.
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
Hong S, Beja-Glasser VF, Nfonoyim BM, et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016;352(6286):712-716. doi:10.1126/science.aad8373.
Use of the MS2 aptamer and coat protein for RNA localization in yeast: A response to "MS2 coat proteins bound to yeast mRNAs block 5' to 3' degradation and trap mRNA decay products: implications for the localization of mRNAs by MS2-MCP system".
Haimovich G, Zabezhinsky D, Haas B, et al. Use of the MS2 aptamer and coat protein for RNA localization in yeast: A response to "MS2 coat proteins bound to yeast mRNAs block 5' to 3' degradation and trap mRNA decay products: implications for the localization of mRNAs by MS2-MCP system". RNA. 2016;22(5):660-6. doi:10.1261/rna.055095.115.
Neurobiology of social behavior abnormalities in autism and Williams syndrome.
Barak B, Feng G. Neurobiology of social behavior abnormalities in autism and Williams syndrome. Nat Neurosci. 2016;19(6):647-55. doi:10.1038/nn.4276.
Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice.
Wells MF, Wimmer RD, L Schmitt I, Feng G, Halassa MM. Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice. Nature. 2016;532(7597):58-63. doi:10.1038/nature17427.
Modeling ALS with motor neurons derived from human induced pluripotent stem cells.
Sances S, Bruijn LI, Chandran S, et al. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016;19(4):542-53. doi:10.1038/nn.4273.
Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures.
Lu Y, Zhong C, Wang L, et al. Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nat Commun. 2016;7:10962. doi:10.1038/ncomms10962.
Stressed out? Healing Tips for Newly Reprogrammed Neurons.
Quadrato G, Zhang AC, Arlotta P. Stressed out? Healing Tips for Newly Reprogrammed Neurons. Cell Stem Cell. 2016;18(3):297-9. doi:10.1016/j.stem.2016.02.008.
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.
Mei Y, Monteiro P, Zhou Y, et al. Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature. 2016;530(7591):481-4. doi:10.1038/nature16971.
Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.
Ma L, Chen Z, Huang DWei, et al. Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts. Nat Commun. 2016;7:10740. doi:10.1038/ncomms10740.
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.
Wagner FF, Lundh M, Kaya T, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol. 2016;11(2):363-74. doi:10.1021/acschembio.5b00640.
Cellular neuroscience. Differences among astrocytes.
Stevens B, Muthukumar AK. Cellular neuroscience. Differences among astrocytes. Science. 2016;351(6275):813. doi:10.1126/science.aaf2849.
Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.
Zhang Q, Gao X, Li C, et al. Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016;36(7):2247-60. doi:10.1523/JNEUROSCI.2528-15.2016.
Schizophrenia risk from complex variation of complement component 4.
Sekar A, Bialas AR, de Rivera H, et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530(7589):177-83. doi:10.1038/nature16549.
CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors.
Loebrich S, Benoit MRobert, Konopka JAleksandra, Cottrell JRichard, Gibson J, Nedivi E. CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors. Curr Biol. 2016;26(3):296-308. doi:10.1016/j.cub.2015.11.071.
Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3.
Lu C, Chen Q, Zhou T, et al. Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3. Mol Psychiatry. 2016;21(2):159-68. doi:10.1038/mp.2015.173.
Seq-ing the cortex one neuron at a time.
Chen H-H, Arlotta P. Seq-ing the cortex one neuron at a time. Nat Neurosci. 2016;19(2):179-81. doi:10.1038/nn.4230.
New insights on the role of microglia in synaptic pruning in health and disease.
Hong S, Dissing-Olesen L, Stevens B. New insights on the role of microglia in synaptic pruning in health and disease. Curr Opin Neurobiol. 2016;36:128-34. doi:10.1016/j.conb.2015.12.004.
Diversity Matters: A Revised Guide to Myelination.
Tomassy GSrubek, Dershowitz LBowe, Arlotta P. Diversity Matters: A Revised Guide to Myelination. Trends Cell Biol. 2016;26(2):135-147. doi:10.1016/j.tcb.2015.09.002.
Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis.
Cottrell JR, Li B, Kyung JWon, et al. Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. J Biol Chem. 2016;291(4):1948-56. doi:10.1074/jbc.M115.705319.
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.
Zhou Y, Kaiser T, Monteiro P, et al. Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects. Neuron. 2016;89(1):147-62. doi:10.1016/j.neuron.2015.11.023.
Striatal magnetic resonance spectroscopy abnormalities in young adult SAPAP3 knockout mice.
Mintzopoulos D, Gillis TE, Robertson HR, et al. Striatal magnetic resonance spectroscopy abnormalities in young adult SAPAP3 knockout mice. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016;1(1):39-48. doi:10.1016/j.bpsc.2015.10.001.
Learning From Animal Models of Obsessive-Compulsive Disorder.
Monteiro P, Feng G. Learning From Animal Models of Obsessive-Compulsive Disorder. Biol Psychiatry. 2016;79(1):7-16. doi:10.1016/j.biopsych.2015.04.020.
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.
Brennand KJ, M Marchetto C, Benvenisty N, et al. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015;5(6):933-945. doi:10.1016/j.stemcr.2015.10.011.
Homeotic Transformations of Neuronal Cell Identities.
Arlotta P, Hobert O. Homeotic Transformations of Neuronal Cell Identities. Trends Neurosci. 2015;38(12):751-62. doi:10.1016/j.tins.2015.10.005.
Tracks through the genome to physiological events.
Lipscombe D, Pan JQ, Schorge S. Tracks through the genome to physiological events. Exp Physiol. 2015;100(12):1429-40. doi:10.1113/EP085129.
Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy.
Ng S-Y, Soh BSeng, Rodriguez-Muela N, et al. Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy. Cell Stem Cell. 2015;17(5):569-84. doi:10.1016/j.stem.2015.08.003.
Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons.
Ye Z, Mostajo-Radji MA, Brown JR, et al. Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons. Neuron. 2015;88(3):475-83. doi:10.1016/j.neuron.2015.10.006.
Do glia drive synaptic and cognitive impairment in disease?
Chung W-S, Welsh CA, Barres BA, Stevens B. Do glia drive synaptic and cognitive impairment in disease?. Nat Neurosci. 2015;18(11):1539-1545. doi:10.1038/nn.4142.
Microglia: Dynamic Mediators of Synapse Development and Plasticity.
Wu Y, Dissing-Olesen L, MacVicar BA, Stevens B. Microglia: Dynamic Mediators of Synapse Development and Plasticity. Trends Immunol. 2015;36(10):605-13. doi:10.1016/j.it.2015.08.008.
Genome Sequences of Three Phytopathogenic Species of the Magnaporthaceae Family of Fungi.
Okagaki LH, Nunes CC, Sailsbery J, et al. Genome Sequences of Three Phytopathogenic Species of the Magnaporthaceae Family of Fungi. G3 (Bethesda). 2015;5(12):2539-45. doi:10.1534/g3.115.020057.
Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline.
Shi Q, Colodner KJ, Matousek SB, et al. Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. J Neurosci. 2015;35(38):13029-42. doi:10.1523/JNEUROSCI.1698-15.2015.
Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.
Hyman SE. Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders. Cell Stem Cell. 2015;17(3):253-4. doi:10.1016/j.stem.2015.08.013.
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.
Paull D, Sevilla A, Zhou H, et al. Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nat Methods. 2015;12(9):885-92. doi:10.1038/nmeth.3507.
Modeling psychiatric disorders for developing effective treatments.
Kaiser T, Feng G. Modeling psychiatric disorders for developing effective treatments. Nat Med. 2015;21(9):979-88. doi:10.1038/nm.3935.
Microglia function during brain development: New insights from animal models.
Bilimoria PM, Stevens B. Microglia function during brain development: New insights from animal models. Brain Res. 2015;1617:7-17. doi:10.1016/j.brainres.2014.11.032.
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.
Andersen KG, B Shapiro J, Matranga CB, et al. Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus. Cell. 2015;162(4):738-50. doi:10.1016/j.cell.2015.07.020.
Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia.
Rees E, Kirov G, Walters JT, et al. Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia. Transl Psychiatry. 2015;5:e607. doi:10.1038/tp.2015.99.
Microglia Function in Central Nervous System Development and Plasticity.
Schafer DP, Stevens B. Microglia Function in Central Nervous System Development and Plasticity. Cold Spring Harb Perspect Biol. 2015;7(10):a020545. doi:10.1101/cshperspect.a020545.
From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.
McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K. From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell Stem Cell. 2015;17(1):8-10. doi:10.1016/j.stem.2015.06.013.
Focus on induced pluripotency and cellular reprogramming.
Schwarz-Romond T, Kiskinis E, Eggan K. Focus on induced pluripotency and cellular reprogramming. EMBO J. 2015;34(11):1435. doi:10.15252/embj.201591615.
Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain.
Goff LA, Groff AF, Sauvageau M, et al. Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain. Proc Natl Acad Sci U S A. 2015;112(22):6855-62. doi:10.1073/pnas.1411263112.
Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus.
Merkle FT, Neuhausser WM, Santos D, et al. Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus. Cell Rep. 2015;11(6):875-883. doi:10.1016/j.celrep.2015.04.007.
Brains, genes, and primates.
Belmonte JCarlos Izp, Callaway EM, Caddick SJ, et al. Brains, genes, and primates. Neuron. 2015;86(3):617-31. doi:10.1016/j.neuron.2015.03.021.
CRISPR germline engineering--the community speaks.
Bosley KS, Botchan M, Bredenoord AL, et al. CRISPR germline engineering--the community speaks. Nat Biotechnol. 2015;33(5):478-86. doi:10.1038/nbt.3227.
Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.
Olson DE, Sleiman SF, Bourassa MW, et al. Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism. Chem Biol. 2015;22(4):439-445. doi:10.1016/j.chembiol.2015.03.014.
Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages.
Schafer DP, Stevens B. Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages. Immunity. 2015;42(4):600-2. doi:10.1016/j.immuni.2015.04.002.
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.
Chen S, Sanjana NE, Zheng K, et al. Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell. 2015;160(6):1246-60. doi:10.1016/j.cell.2015.02.038.
Seven actionable strategies for advancing women in science, engineering, and medicine.
Smith KA, Arlotta P, Watt FM, Solomon SL. Seven actionable strategies for advancing women in science, engineering, and medicine. Cell Stem Cell. 2015;16(3):221-4. doi:10.1016/j.stem.2015.02.012.
Discovery of novel rhabdoviruses in the blood of healthy individuals from West Africa.
Stremlau MH, Andersen KG, Folarin OA, et al. Discovery of novel rhabdoviruses in the blood of healthy individuals from West Africa. PLoS Negl Trop Dis. 2015;9(3):e0003631. doi:10.1371/journal.pntd.0003631.
Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.
Merkle FT, Maroof A, Wataya T, et al. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development. 2015;142(4):633-43. doi:10.1242/dev.117978.
NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma.
Wang H, Pan J-Q, Luo L, et al. NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma. Mol Cancer. 2015;14:2. doi:10.1186/1476-4598-14-2.
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.
Yoshimizu T, Pan JQ, Mungenast AE, et al. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015;20(2):284. doi:10.1038/mp.2014.181.
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.
Yoshimizu T, Pan JQ, Mungenast AE, et al. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015;20(2):162-9. doi:10.1038/mp.2014.143.
Cerebral cortex assembly: generating and reprogramming projection neuron diversity.
Lodato S, Shetty AS, Arlotta P. Cerebral cortex assembly: generating and reprogramming projection neuron diversity. Trends Neurosci. 2015;38(2):117-25. doi:10.1016/j.tins.2014.11.003.
Striatal circuits, habits, and implications for obsessive-compulsive disorder.
Burguière E, Monteiro P, Mallet L, Feng G, Graybiel AM. Striatal circuits, habits, and implications for obsessive-compulsive disorder. Curr Opin Neurobiol. 2015;30:59-65. doi:10.1016/j.conb.2014.08.008.
Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.
Toma JS, Shettar BC, Chipman PH, et al. Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons. J Neurosci. 2015;35(3):1291-306. doi:10.1523/JNEUROSCI.2126-14.2015.
DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.
Molyneaux BJ, Goff LA, Brettler AC, et al. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 2015;85(2):275-288. doi:10.1016/j.neuron.2014.12.024.
The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.
Giera S, Deng Y, Luo R, et al. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015;6:6121. doi:10.1038/ncomms7121.
A perspective on stem cell modeling of amyotrophic lateral sclerosis.
A de Boer S, Eggan K. A perspective on stem cell modeling of amyotrophic lateral sclerosis. Cell Cycle. 2015;14(23):3679-88. doi:10.1080/15384101.2015.1093712.
A comparison of non-integrating reprogramming methods.
Schlaeger TM, Daheron L, Brickler TR, et al. A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015;33(1):58-63. doi:10.1038/nbt.3070.
Building blocks of the cerebral cortex: from development to the dish.
Harris J, Tomassy GSrubek, Arlotta P. Building blocks of the cerebral cortex: from development to the dish. Wiley Interdiscip Rev Dev Biol. 2015;4(5):529-44. doi:10.1002/wdev.192.
Generating neuronal diversity in the mammalian cerebral cortex.
Lodato S, Arlotta P. Generating neuronal diversity in the mammalian cerebral cortex. Annu Rev Cell Dev Biol. 2015;31:699-720. doi:10.1146/annurev-cellbio-100814-125353.
Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.
Wainger BJ, Buttermore ED, Oliveira JT, et al. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015;18(1):17-24. doi:10.1038/nn.3886.
Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers.
Wagner FF, Zhang Y-L, Fass DM, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015;6(1):804-815. doi:10.1039/C4SC02130D.
Astrocytes refine cortical connectivity at dendritic spines.
W Risher C, Patel S, Kim IHwan, et al. Astrocytes refine cortical connectivity at dendritic spines. Elife. 2014;3. doi:10.7554/eLife.04047.
iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease.
Woodard CM, Campos BA, Kuo S-H, et al. iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell Rep. 2014;9(4):1173-82. doi:10.1016/j.celrep.2014.10.023.
Genetic variation in human DNA replication timing.
Koren A, Handsaker RE, Kamitaki N, et al. Genetic variation in human DNA replication timing. Cell. 2014;159(5):1015-1026. doi:10.1016/j.cell.2014.10.025.
Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.
Sleiman SF, Olson DE, Bourassa MW, et al. Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition. J Neurosci. 2014;34(43):14328-37. doi:10.1523/JNEUROSCI.1010-14.2014.
An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.
Olson DE, Udeshi ND, Wolfson NA, et al. An unbiased approach to identify endogenous substrates of "histone" deacetylase 8. ACS Chem Biol. 2014;9(10):2210-6. doi:10.1021/cb500492r.
In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs.
Wang C, Schroeder FA, Wey H-Y, et al. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. J Med Chem. 2014;57(19):7999-8009. doi:10.1021/jm500872p.
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
Ruderfer DM, Fanous AH, Ripke S, et al. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Mol Psychiatry. 2014;19(9):1017-24. doi:10.1038/mp.2013.138.
Sensory integration in mouse insular cortex reflects GABA circuit maturation.
Gogolla N, Takesian AE, Feng G, Fagiolini M, Hensch TK. Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron. 2014;83(4):894-905. doi:10.1016/j.neuron.2014.06.033.
Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.
Naryshkin NA, Weetall M, Dakka A, et al. Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. Science. 2014;345(6197):688-93. doi:10.1126/science.1250127.
Genetic validation of a therapeutic target in a mouse model of ALS.
A de Boer S, Koszka K, Kiskinis E, Suzuki N, Davis-Dusenbery BN, Eggan K. Genetic validation of a therapeutic target in a mouse model of ALS. Sci Transl Med. 2014;6(248):248ra104. doi:10.1126/scitranslmed.3009351.
Brains in metamorphosis: reprogramming cell identity within the central nervous system.
Arlotta P, Berninger B. Brains in metamorphosis: reprogramming cell identity within the central nervous system. Curr Opin Neurobiol. 2014;27:208-14. doi:10.1016/j.conb.2014.04.007.
Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.
Lodato S, Molyneaux BJ, Zuccaro E, et al. Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014;17(8):1046-54. doi:10.1038/nn.3757.
Notch inhibition allows oncogene-independent generation of iPS cells.
Ichida JK, TCW J, Williams LA, et al. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014;10(8):632-639. doi:10.1038/nchembio.1552.
Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'.
Robinson EB, Howrigan D, Yang J, et al. Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'. Mol Psychiatry. 2014;19(8):859-61. doi:10.1038/mp.2013.125.
DNA methylation dynamics of the human preimplantation embryo.
Smith ZD, Chan MM, Humm KC, et al. DNA methylation dynamics of the human preimplantation embryo. Nature. 2014;511(7511):611-5. doi:10.1038/nature13581.
Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.
Seo YJun, Kang Y, Muench L, et al. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. ACS Chem Neurosci. 2014;5(7):588-96. doi:10.1021/cn500021p.
Copy number variation in schizophrenia in Sweden.
Szatkiewicz JP, O'Dushlaine C, Chen G, et al. Copy number variation in schizophrenia in Sweden. Mol Psychiatry. 2014;19(7):762-73. doi:10.1038/mp.2014.40.
Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure.
Grad YH, Newman R, Zody M, et al. Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure. J Virol. 2014;88(13):7286-93. doi:10.1128/JVI.00038-14.
Studies toward the total synthesis of dihydrolycolucine. Preparation of AB and CEF ring fragments.
Cash BM, Prevost N, Wagner FF, Comins DL. Studies toward the total synthesis of dihydrolycolucine. Preparation of AB and CEF ring fragments. J Org Chem. 2014;79(12):5740-5. doi:10.1021/jo500878v.
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis.
Morris DW, Pearson RD, Cormican P, et al. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet. 2014;23(12):3316-26. doi:10.1093/hmg/ddu025.
Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses.
Kim J, Lee S, Tsuda S, et al. Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses. Cell Rep. 2014;7(5):1601-1613. doi:10.1016/j.celrep.2014.04.047.
An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons.
Schafer DP, Lehrman EK, Heller CT, Stevens B. An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. J Vis Exp. 2014;(88). doi:10.3791/51482.
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.
Kiskinis E, Sandoe J, Williams LA, et al. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014;14(6):781-95. doi:10.1016/j.stem.2014.03.004.
Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families.
Blumenthal I, Ragavendran A, Erdin S, et al. Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families. Am J Hum Genet. 2014;94(6):870-83. doi:10.1016/j.ajhg.2014.05.004.
Genome-scale neurogenetics: methodology and meaning.
McCarroll SA, Feng G, Hyman SE. Genome-scale neurogenetics: methodology and meaning. Nat Neurosci. 2014;17(6):756-63. doi:10.1038/nn.3716.
Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment.
Haidet-Phillips AM, Roybon L, Gross SK, et al. Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment. Stem Cells Transl Med. 2014;3(5):575-85. doi:10.5966/sctm.2013-0153.
Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder.
Wan Y, Ade KK, Caffall Z, et al. Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. Biol Psychiatry. 2014;75(8):623-30. doi:10.1016/j.biopsych.2013.01.008.
Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.
Wainger BJ, Kiskinis E, Mellin C, et al. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014;7(1):1-11. doi:10.1016/j.celrep.2014.03.019.
Selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions.
Han Y, Shi Y-feng, Xi W, et al. Selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions. Curr Biol. 2014;24(6):693-8. doi:10.1016/j.cub.2014.02.011.
Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder.
Tang R, Noh HJi, Wang D, et al. Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder. Genome Biol. 2014;15(3):R25. doi:10.1186/gb-2014-15-3-r25.
De novo mutations in schizophrenia implicate synaptic networks.
Fromer M, Pocklington AJ, Kavanagh DH, et al. De novo mutations in schizophrenia implicate synaptic networks. Nature. 2014;506(7487):179-84. doi:10.1038/nature12929.
A polygenic burden of rare disruptive mutations in schizophrenia.
Purcell SM, Moran JL, Fromer M, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506(7487):185-90. doi:10.1038/nature12975.
Nanog-independent reprogramming to iPSCs with canonical factors.
Carter AC, Davis-Dusenbery BN, Koszka K, Ichida JK, Eggan K. Nanog-independent reprogramming to iPSCs with canonical factors. Stem Cell Reports. 2014;2(2):119-26. doi:10.1016/j.stemcr.2013.12.010.
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
Alami NH, Smith RB, Carrasco MA, et al. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 2014;81(3):536-543. doi:10.1016/j.neuron.2013.12.018.
Development of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neurons.
Chan B, Cottrell JR, Li B, et al. Development of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neurons. J Biomol Screen. 2014;19(2):205-14. doi:10.1177/1087057113505905.
How to make spinal motor neurons.
Davis-Dusenbery BN, Williams LA, Klim JR, Eggan K. How to make spinal motor neurons. Development. 2014;141(3):491-501. doi:10.1242/dev.097410.
Development-inspired reprogramming of the mammalian central nervous system.
Amamoto R, Arlotta P. Development-inspired reprogramming of the mammalian central nervous system. Science. 2014;343(6170):1239882. doi:10.1126/science.1239882.
Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.
Gräff J, Joseph NF, Horn ME, et al. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell. 2014;156(1-2):261-76. doi:10.1016/j.cell.2013.12.020.
Flow of cortical activity underlying a tactile decision in mice.
Guo ZV, Li N, Huber D, et al. Flow of cortical activity underlying a tactile decision in mice. Neuron. 2014;81(1):179-94. doi:10.1016/j.neuron.2013.10.020.
The role of muscle microRNAs in repairing the neuromuscular junction.
Valdez G, Heyer MP, Feng G, Sanes JR. The role of muscle microRNAs in repairing the neuromuscular junction. PLoS One. 2014;9(3):e93140. doi:10.1371/journal.pone.0093140.
Recombineering strategies for developing next generation BAC transgenic tools for optogenetics and beyond.
Ting JT, Feng G. Recombineering strategies for developing next generation BAC transgenic tools for optogenetics and beyond. Front Behav Neurosci. 2014;8:111. doi:10.3389/fnbeh.2014.00111.
Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples.
Matranga CB, Andersen KG, Winnicki S, et al. Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples. Genome Biol. 2014;15(11):519. doi:10.1186/PREACCEPT-1698056557139770.
Selective HDAC inhibition for the disruption of latent HIV-1 infection.
Barton KM, Archin NM, Keedy KS, et al. Selective HDAC inhibition for the disruption of latent HIV-1 infection. PLoS One. 2014;9(8):e102684. doi:10.1371/journal.pone.0102684.
Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics.
Ting JT, Daigle TL, Chen Q, Feng G. Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics. Methods Mol Biol. 2014;1183:221-42. doi:10.1007/978-1-4939-1096-0_14.
Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA.
Miranda KC, Bond DT, Levin JZ, et al. Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA. PLoS One. 2014;9(5):e96094. doi:10.1371/journal.pone.0096094.
Fast modulation of visual perception by basal forebrain cholinergic neurons.
Pinto L, Goard MJ, Estandian D, et al. Fast modulation of visual perception by basal forebrain cholinergic neurons. Nat Neurosci. 2013;16(12):1857-1863. doi:10.1038/nn.3552.
Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.
Loebrich S, Djukic B, Tong ZJ, Cottrell JR, Turrigiano GG, Nedivi E. Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Proc Natl Acad Sci U S A. 2013;110(47):E4548-56. doi:10.1073/pnas.1318860110.
Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology.
McCarroll SA, Hyman SE. Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology. Neuron. 2013;80(3):578-87. doi:10.1016/j.neuron.2013.10.046.
Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience.
Ting JT, Feng G. Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience. Behav Brain Res. 2013;255:3-18. doi:10.1016/j.bbr.2013.02.037.
Small molecule inhibitors of zinc-dependent histone deacetylases.
Wagner FF, Weїwer M, Lewis MC, Holson EB. Small molecule inhibitors of zinc-dependent histone deacetylases. Neurotherapeutics. 2013;10(4):589-604. doi:10.1007/s13311-013-0226-1.
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
Ripke S, O'Dushlaine C, Chambert K, et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013;45(10):1150-9. doi:10.1038/ng.2742.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
S Lee H, Ripke S, Neale BM, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013;45(9):984-94. doi:10.1038/ng.2711.
Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia.
Weïwer M, Lewis MC, Wagner FF, Holson EB. Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia. Future Med Chem. 2013;5(13):1491-508. doi:10.4155/fmc.13.141.
FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors.
Schroeder FA, Chonde DB, Riley MM, et al. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neurosci Lett. 2013;550:119-24. doi:10.1016/j.neulet.2013.06.016.
Validating therapeutic targets through human genetics.
Plenge RM, Scolnick EM, Altshuler D. Validating therapeutic targets through human genetics. Nat Rev Drug Discov. 2013;12(8):581-94. doi:10.1038/nrd4051.
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex.
Cottrell JR, Levenson JM, Kim SHyun, et al. Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex. J Neurosci. 2013;33(27):10938-49. doi:10.1523/JNEUROSCI.5362-12.2013.
Class I HDAC imaging using [ (3)H]CI-994 autoradiography.
Wang Y, Zhang Y-L, Hennig K, et al. Class I HDAC imaging using [ (3)H]CI-994 autoradiography. Epigenetics. 2013;8(7):756-64. doi:10.4161/epi.25202.
ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domains.
Kolisnyk B, Guzman MS, Raulic S, et al. ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domains. J Neurosci. 2013;33(25):10427-38. doi:10.1523/JNEUROSCI.0395-13.2013.
Discovery of the first histone deacetylase 6/8 dual inhibitors.
Olson DE, Wagner FF, Kaya T, et al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013;56(11):4816-20. doi:10.1021/jm400390r.
Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.
Ferguson BS, Harrison BC, Jeong MY, et al. Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2013;110(24):9806-11. doi:10.1073/pnas.1301509110.
Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors.
Burguière E, Monteiro P, Feng G, Graybiel AM. Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science. 2013;340(6137):1243-6. doi:10.1126/science.1232380.
Optical inhibition of motor nerve and muscle activity in vivo.
Liske H, Towne C, Anikeeva P, et al. Optical inhibition of motor nerve and muscle activity in vivo. Muscle Nerve. 2013;47(6):916-21. doi:10.1002/mus.23696.
Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation.
Frumm SM, Fan ZPeng, Ross KN, et al. Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chem Biol. 2013;20(5):713-25. doi:10.1016/j.chembiol.2013.03.020.
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.
Wagner FF, Olson DE, Gale JP, et al. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem. 2013;56(4):1772-6. doi:10.1021/jm301355j.
Cortical control of affective networks.
Kumar S, Black SJ, Hultman R, et al. Cortical control of affective networks. J Neurosci. 2013;33(3):1116-29. doi:10.1523/JNEUROSCI.0092-12.2013.
Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.
Wang C, Eessalu TE, Barth VN, et al. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. Am J Nucl Med Mol Imaging. 2013;4(1):29-38.
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.
Schroeder FA, Lewis MC, Fass DM, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS One. 2013;8(8):e71323. doi:10.1371/journal.pone.0071323.
Next-generation transgenic mice for optogenetic analysis of neural circuits.
Asrican B, Augustine GJ, Berglund K, et al. Next-generation transgenic mice for optogenetic analysis of neural circuits. Front Neural Circuits. 2013;7:160. doi:10.3389/fncir.2013.00160.
Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease.
Chen R, Zhang J, Wu Y, et al. Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Cell Rep. 2012;2(5):1329-39. doi:10.1016/j.celrep.2012.09.030.
Imaging neural activity using Thy1-GCaMP transgenic mice.
Chen Q, Cichon J, Wang W, et al. Imaging neural activity using Thy1-GCaMP transgenic mice. Neuron. 2012;76(2):297-308. doi:10.1016/j.neuron.2012.07.011.
Cellular and synaptic network defects in autism.
Peça J, Feng G. Cellular and synaptic network defects in autism. Curr Opin Neurobiol. 2012;22(5):866-72. doi:10.1016/j.conb.2012.02.015.
Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.
Lowe JT, Lee MD, Akella LB, et al. Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries. J Org Chem. 2012;77(17):7187-211. doi:10.1021/jo300974j.
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
Bergen SE, O'Dushlaine CT, Ripke S, et al. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry. 2012;17(9):880-6. doi:10.1038/mp.2012.73.
Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5.
Su SC, Seo J, Pan JQ, et al. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron. 2012;75(4):675-87. doi:10.1016/j.neuron.2012.06.023.
Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice.
Heyer MP, Pani AK, Smeyne RJ, Kenny PJ, Feng G. Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice. J Neurosci. 2012;32(32):10887-94. doi:10.1523/JNEUROSCI.1732-12.2012.
Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis.
Chou DHung-Chieh, Holson EB, Wagner FF, et al. Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. Chem Biol. 2012;19(6):669-73. doi:10.1016/j.chembiol.2012.05.010.
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.
Kubicek S, Gilbert JC, Fomina-Yadlin D, et al. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. Proc Natl Acad Sci U S A. 2012;109(14):5364-9. doi:10.1073/pnas.1201079109.
A transcription activator-like effector toolbox for genome engineering.
Sanjana NE, Cong L, Zhou Y, Cunniff MM, Feng G, Zhang F. A transcription activator-like effector toolbox for genome engineering. Nat Protoc. 2012;7(1):171-92. doi:10.1038/nprot.2011.431.
Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders.
Ting JT, Peça J, Feng G. Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders. Annu Rev Neurosci. 2012;35:49-71. doi:10.1146/annurev-neuro-062111-150442.
Discovery of Potent and Highly Selective Inhibitors of GSK3b
W. An F, Germain AR, Bishop J, et al. Discovery of Potent and Highly Selective Inhibitors of GSK3b. Bethesda, MD: National Center for Biotechnology Information (US); 2012. Available at: https://www.ncbi.nlm.nih.gov/books/NBK133436/.
Imaging synaptic inhibition with the genetically encoded chloride indicator Clomeleon.
Berglund K, Kuner T, Feng G, Augustine GJ. Imaging synaptic inhibition with the genetically encoded chloride indicator Clomeleon. Cold Spring Harb Protoc. 2011;2011(12):1492-7. doi:10.1101/pdb.prot066985.
Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics.
Ting JT, Feng G. Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics. Curr Opin Neurobiol. 2011;21(6):842-8. doi:10.1016/j.conb.2011.04.010.
Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses.
Wan Y, Feng G, Calakos N. Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. J Neurosci. 2011;31(46):16685-91. doi:10.1523/JNEUROSCI.2533-11.2011.
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.
Sun F, Park KK, Belin S, et al. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011;480(7377):372-5. doi:10.1038/nature10594.
Unfolding neurodevelopmental disorders: found in translation.
Ting JT, Feng G. Unfolding neurodevelopmental disorders: found in translation. Nat Med. 2011;17(11):1352-3. doi:10.1038/nm.2553.
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.
Chen X, Lee G, Maher BS, et al. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Mol Psychiatry. 2011;16(11):1117-29. doi:10.1038/mp.2010.96.
SnapShot: Autism and the synapse.
Peça J, Ting J, Feng G. SnapShot: Autism and the synapse. Cell. 2011;147(3):706, 706.e1. doi:10.1016/j.cell.2011.10.015.
Advancing drug discovery for schizophrenia.
Marder SR, Roth B, Sullivan PF, et al. Advancing drug discovery for schizophrenia. Ann N Y Acad Sci. 2011;1236:30-43. doi:10.1111/j.1749-6632.2011.06216.x.
The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.
Wilson AJ, Holson E, Wagner F, et al. The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biol Ther. 2011;12(6):484-93. doi:10.4161/cbt.12.6.15956.
Neuroscience: When lights take the circuits out.
Peça J, Feng G. Neuroscience: When lights take the circuits out. Nature. 2011;477(7363):165-6. doi:10.1038/477165a.
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function.
Zhao S, Ting JT, Atallah HE, et al. Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods. 2011;8(9):745-52.
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
Kuai L, Ong S-E, Madison JM, et al. AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chem Biol. 2011;18(7):891-906. doi:10.1016/j.chembiol.2011.03.017.
Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles.
Halassa MM, Siegle JH, Ritt JT, Ting JT, Feng G, Moore CI. Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles. Nat Neurosci. 2011;14(9):1118-20. doi:10.1038/nn.2880.
Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity.
Chen M, Wan Y, Ade K, Ting J, Feng G, Calakos N. Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. J Neurosci. 2011;31(26):9563-73. doi:10.1523/JNEUROSCI.1701-11.2011.
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.
Pan JQ, Lewis MC, Ketterman JK, et al. AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology. 2011;36(7):1397-411. doi:10.1038/npp.2011.24.
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction.
Peça J, Feliciano C, Ting JT, et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature. 2011;472(7344):437-42. doi:10.1038/nature09965.
Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.
Robertson HR, Feng G. Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders. J Child Psychol Psychiatry. 2011;52(4):442-75. doi:10.1111/j.1469-7610.2011.02380.x.
Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes.
Ren J, Qin C, Hu F, et al. Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron. 2011;69(3):445-52. doi:10.1016/j.neuron.2010.12.038.
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
Liu Y, Blackwood DH, Caesar S, et al. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry. 2011;16(1):2-4. doi:10.1038/mp.2009.107.
A system for performing high throughput assays of synaptic function.
Hempel CM, Sivula M, Levenson JM, et al. A system for performing high throughput assays of synaptic function. PLoS One. 2011;6(10):e25999. doi:10.1371/journal.pone.0025999.
Hdac3 is essential for the maintenance of chromatin structure and genome stability.
Bhaskara S, Knutson SK, Jiang G, et al. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell. 2010;18(5):436-47. doi:10.1016/j.ccr.2010.10.022.
Medicine. The future of psychiatric research: genomes and neural circuits.
Akil H, Brenner S, Kandel E, et al. Medicine. The future of psychiatric research: genomes and neural circuits. Science. 2010;327(5973):1580-1. doi:10.1126/science.1188654.
Characterization of plant-derived saponin natural products against Candida albicans.
Coleman JJ, Okoli I, Tegos GP, et al. Characterization of plant-derived saponin natural products against Candida albicans. ACS Chem Biol. 2010;5(3):321-32. doi:10.1021/cb900243b.
Support of association between BRD1 and both schizophrenia and bipolar affective disorder.
Nyegaard M, Severinsen JE, Als TD, et al. Support of association between BRD1 and both schizophrenia and bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet. 2010;153B(2):582-591. doi:10.1002/ajmg.b.31023.
Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.
Kuai L, Wang X, Madison JM, Schreiber SL, Scolnick EM, Haggarty SJ. Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling. ACS Chem Neurosci. 2010;1(4):325-342. doi:10.1021/cn900046a.
Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.
Okoli I, Coleman JJ, Tampakakis E, et al. Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay. PLoS One. 2009;4(9):e7025. doi:10.1371/journal.pone.0007025.
Tripping the HCN breaker.
Lipscombe D, Pan JQian. Tripping the HCN breaker. Neuron. 2009;62(6):747-50. doi:10.1016/j.neuron.2009.06.003.
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
Raychaudhuri S, Plenge RM, Rossin EJ, et al. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet. 2009;5(6):e1000534. doi:10.1371/journal.pgen.1000534.
A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.
Perlis RH, Smoller JW, Ferreira MAR, et al. A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder. Am J Psychiatry. 2009;166(6):718-25. doi:10.1176/appi.ajp.2009.08111633.
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
Ferreira MAR, O'Donovan MC, Meng YA, et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008;40(9):1056-8. doi:10.1038/ng.209.
Whole-genome association study of bipolar disorder.
Sklar P, Smoller JW, Fan J, et al. Whole-genome association study of bipolar disorder. Mol Psychiatry. 2008;13(6):558-69. doi:10.1038/sj.mp.4002151.
Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
Mutsuddi M, Morris DW, Waggoner SG, Daly MJ, Scolnick EM, Sklar P. Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia. Am J Hum Genet. 2006;79(5):903-9. doi:10.1086/508942.
Recurrence risks for schizophrenia in a Swedish national cohort.
Lichtenstein P, Björk C, Hultman CM, Scolnick E, Sklar P, Sullivan PF. Recurrence risks for schizophrenia in a Swedish national cohort. Psychol Med. 2006;36(10):1417-25. doi:10.1017/S0033291706008385.
A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase.
Brandish PE, Chiu C-S, Schneeweis J, et al. A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase. J Biomol Screen. 2006;11(5):481-7. doi:10.1177/1087057106288181.
Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations.
Scolnick EM. Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations. Biol Psychiatry. 2006;59(11):1039-45. doi:10.1016/j.biopsych.2006.02.022.
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.
Xiong Y, Wiltsie J, Woods A, et al. The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006;16(4):964-8. doi:10.1016/j.bmcl.2005.10.088.
Cure therapeutics and strategic prevention: raising the bar for mental health research.
Insel TR, Scolnick EM. Cure therapeutics and strategic prevention: raising the bar for mental health research. Mol Psychiatry. 2006;11(1):11-7. doi:10.1038/sj.mp.4001777.
Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?
Scolnick EM, Petryshen T, Sklar P. Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?. Harv Rev Psychiatry. 2006;14(2):64-77. doi:10.1080/10673220600642960.
Anthrax lethal factor inhibition.
Shoop WL, Xiong Y, Wiltsie J, et al. Anthrax lethal factor inhibition. Proc Natl Acad Sci U S A. 2005;102(22):7958-63. doi:10.1073/pnas.0502159102.
Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex.
Brandish PE, Su M, Holder DJ, et al. Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex. Neuron. 2005;45(6):861-72. doi:10.1016/j.neuron.2005.02.006.
Program to improve cognitive functioning in patients with schizophrenia: reflections.
Scolnick E. Program to improve cognitive functioning in patients with schizophrenia: reflections. Schizophr Res. 2004;72(1):75-7. doi:10.1016/j.schres.2004.09.005.
High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors.
Zheng W, Brandish PE, D Kolodin G, Scolnick EM, Strulovici B. High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors. J Biomol Screen. 2004;9(2):132-40. doi:10.1177/1087057103261039.
Effect of pH on ionic exchange and function in rat and rabbit myocardium.
Poole-Wilson PA, Langer GA. Effect of pH on ionic exchange and function in rat and rabbit myocardium. Am J Physiol. 1975;229(3):570-81.
Effect of sodium nitrate loading on electrolyte transport by the renal tubule.
Kahn T, Bosch J, Levitt MF, Goldstein MH. Effect of sodium nitrate loading on electrolyte transport by the renal tubule. Am J Physiol. 1975;229(3):746-53.