Stanley Center for Psychiatric Research

A concerted neuron-astrocyte program declines in ageing and schizophrenia.

Ling E, Nemesh J, Goldman M, et al. A concerted neuron-astrocyte program declines in ageing and schizophrenia. Nature. 2024. doi:10.1038/s41586-024-07109-5PubMed DOI Google Scholar

Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice.

Farsi Z, Nicolella A, Simmons SK, et al. Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice. Neuron. 2023. doi:10.1016/j.neuron.2023.08.004PubMed DOI Google Scholar

Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.

Aryal S, Bonanno K, Song B, et al. Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model. Cell reports. 2023;42(5):112497. doi:10.1016/j.celrep.2023.112497PubMed DOI Google Scholar

Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.

Huang Q, Chen AT, Chan KY, et al. Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS biology. 2023;21(7):e3002112. doi:10.1371/journal.pbio.3002112PubMed DOI Google Scholar

Shifting the trajectory of therapeutic development for neurological and psychiatric disorders.

Krainc D, Martin WJ, Casey B, et al. Shifting the trajectory of therapeutic development for neurological and psychiatric disorders. Science translational medicine. 2023;15(720):eadg4775. doi:10.1126/scitranslmed.adg4775PubMed DOI Google Scholar

The molecular cytoarchitecture of the adult mouse brain.

Langlieb J, Sachdev NS, Balderrama KS, et al. The molecular cytoarchitecture of the adult mouse brain. Nature. 2023;624(7991):333-342. doi:10.1038/s41586-023-06818-7PubMed DOI Google Scholar

Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease.

Zeng H, Huang J, Zhou H, et al. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease. Nature neuroscience. 2023. doi:10.1038/s41593-022-01251-xPubMed DOI Google Scholar

Spatial atlas of the mouse central nervous system at molecular resolution.

Shi H, He Y, Zhou Y, et al. Spatial atlas of the mouse central nervous system at molecular resolution. Nature. 2023. doi:10.1038/s41586-023-06569-5PubMed DOI Google Scholar

Pyramidal neuron subtype diversity governs microglia states in the neocortex.

Stogsdill JA, Kim K, Binan L, Farhi SL, Levin JZ, Arlotta P. Pyramidal neuron subtype diversity governs microglia states in the neocortex. Nature. 2022. doi:10.1038/s41586-022-05056-7PubMed DOI Google Scholar

Improving polygenic prediction in ancestrally diverse populations.

Ruan Y, Lin YF, Feng YCA, et al. Improving polygenic prediction in ancestrally diverse populations. Nat Genet. 2022. doi:10.1038/s41588-022-01054-7PubMed DOI Google Scholar