Stanley Center for Psychiatric Research

A concerted neuron-astrocyte program declines in ageing and schizophrenia.

Ling E, Nemesh J, Goldman M, et al. A concerted neuron-astrocyte program declines in ageing and schizophrenia. Nature. 2024. doi:10.1038/s41586-024-07109-5Google Scholar PubMed DOI

Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice.

Farsi Z, Nicolella A, Simmons SK, et al. Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice. Neuron. 2023. doi:10.1016/j.neuron.2023.08.004Google Scholar PubMed DOI

Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.

Aryal S, Bonanno K, Song B, et al. Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model. Cell reports. 2023;42(5):112497. doi:10.1016/j.celrep.2023.112497Google Scholar PubMed DOI

Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.

Huang Q, Chen AT, Chan KY, et al. Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS biology. 2023;21(7):e3002112. doi:10.1371/journal.pbio.3002112Google Scholar PubMed DOI

Shifting the trajectory of therapeutic development for neurological and psychiatric disorders.

Krainc D, Martin WJ, Casey B, et al. Shifting the trajectory of therapeutic development for neurological and psychiatric disorders. Science translational medicine. 2023;15(720):eadg4775. doi:10.1126/scitranslmed.adg4775Google Scholar PubMed DOI

The molecular cytoarchitecture of the adult mouse brain.

Langlieb J, Sachdev NS, Balderrama KS, et al. The molecular cytoarchitecture of the adult mouse brain. Nature. 2023;624(7991):333-342. doi:10.1038/s41586-023-06818-7Google Scholar PubMed DOI

Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease.

Zeng H, Huang J, Zhou H, et al. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease. Nature neuroscience. 2023. doi:10.1038/s41593-022-01251-xGoogle Scholar PubMed DOI

Spatial atlas of the mouse central nervous system at molecular resolution.

Shi H, He Y, Zhou Y, et al. Spatial atlas of the mouse central nervous system at molecular resolution. Nature. 2023. doi:10.1038/s41586-023-06569-5Google Scholar PubMed DOI

Pyramidal neuron subtype diversity governs microglia states in the neocortex.

Stogsdill JA, Kim K, Binan L, Farhi SL, Levin JZ, Arlotta P. Pyramidal neuron subtype diversity governs microglia states in the neocortex. Nature. 2022. doi:10.1038/s41586-022-05056-7Google Scholar PubMed DOI

Improving polygenic prediction in ancestrally diverse populations.

Ruan Y, Lin YF, Feng YCA, et al. Improving polygenic prediction in ancestrally diverse populations. Nat Genet. 2022. doi:10.1038/s41588-022-01054-7Google Scholar PubMed DOI