Stanley Center for Psychiatric Research

Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta.

Kast R, Simmons SK, Rome N, et al. Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta. Proceedings of the National Academy of Sciences of the United States of America. 2026;123(18):e2509781123. doi:10.1073/pnas.2509781123Google Scholar PubMed DOI

Srrm2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a genetic mouse model of schizophrenia.

Aryal S, Geng C, Yin MA, et al. Srrm2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a genetic mouse model of schizophrenia. Cell reports. 2026;45(6):117436. doi:10.1016/j.celrep.2026.117436Google Scholar PubMed DOI

Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na channel dynamics in human neurons.

Cui L, Kurganov E, Hawes D, et al. Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na channel dynamics in human neurons. Molecular psychiatry. 2026. doi:10.1038/s41380-026-03587-3Google Scholar PubMed DOI

Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy.

Moon JS, Moutusy SI, Zhang M, et al. Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy. Proceedings of the National Academy of Sciences of the United States of America. 2026;123(14):e2537271123. doi:10.1073/pnas.2537271123Google Scholar PubMed DOI

Putting polygenic scores in context: How intersectional factors affect relative and absolute genetic risk.

Cudic M, Tubbs JD, Ge T, Smoller JW. Putting polygenic scores in context: How intersectional factors affect relative and absolute genetic risk. American journal of human genetics. 2026. doi:10.1016/j.ajhg.2026.03.013Google Scholar PubMed DOI

Experimental and computational methods for allelic imbalance analysis from single-nucleus RNA-seq data.

Simmons SK, Adiconis X, Haywood N, et al. Experimental and computational methods for allelic imbalance analysis from single-nucleus RNA-seq data. Genome biology. 2026. doi:10.1186/s13059-026-04062-6Google Scholar PubMed DOI

Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia.

Zhou T, Ho YY, Hartley ND, et al. Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia. Nature neuroscience. 2026. doi:10.1038/s41593-026-02237-9Google Scholar PubMed DOI

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding.

Goode TD, Bernstein MX, Totty MS, et al. A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding. Neuron. 2026. doi:10.1016/j.neuron.2026.01.025Google Scholar PubMed DOI

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Wu SJ, Dai M, Yang SP, et al. Pyramidal neurons proportionately alter cortical interneuron subtypes. Nature. 2026. doi:10.1038/s41586-025-09996-8Google Scholar PubMed DOI

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder.

Song BJ, Ge Y, Nicolella A, et al. Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder. Nature communications. 2025;16(1):10793. doi:10.1038/s41467-025-66504-2Google Scholar PubMed DOI