Stanley Center for Psychiatric Research

Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators.

Zhang Y-L, Moran SP, Allen A, et al. Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators. ACS Pharmacol Transl Sci. 2022;5(3):156-168. doi:10.1021/acsptsci.1c00233.DOI Google Scholar PubMed

Characterization of intrinsically disordered regions in proteins informed by human genetic diversity.

Ahmed SS, Rifat ZT, Lohia R, et al. Characterization of intrinsically disordered regions in proteins informed by human genetic diversity. PLoS Comput Biol. 2022;18(3):e1009911. doi:10.1371/journal.pcbi.1009911.DOI Google Scholar PubMed

Predicting functional effects of missense variants in voltage-gated sodium and calcium channels.

Heyne HO, Baez-Nieto D, Iqbal S, et al. Predicting functional effects of missense variants in voltage-gated sodium and calcium channels. Sci Transl Med. 2020;12(556). doi:10.1126/scitranslmed.aay6848.DOI Google Scholar PubMed

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Bis JC, Jian X, Kunkle BW, et al. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol Psychiatry. 2020;25(8):1859-1875. doi:10.1038/s41380-018-0112-7.DOI Google Scholar PubMed

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome.

McCamphill PK, Stoppel LJ, Senter RK, et al. Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome. Sci Transl Med. 2020;12(544). doi:10.1126/scitranslmed.aam8572.DOI Google Scholar PubMed

Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits.

Ghoshal A, Uygun DS, Yang L, et al. Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits. Transl Psychiatry. 2020;10(1):29. doi:10.1038/s41398-020-0685-1.DOI Google Scholar PubMed

Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes.

Guo S-M, Veneziano R, Gordonov S, et al. Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes. Nat Commun. 2019;10(1):4377. doi:10.1038/s41467-019-12372-6.DOI Google Scholar PubMed

Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution.

Rodriques SG, Stickels RR, Goeva A, et al. Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution. Science. 2019;363(6434):1463-1467. doi:10.1126/science.aaw1219.DOI Google Scholar PubMed

Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder

Lei H, Lai J, Sun X, Xu Q, Feng G. Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder. J Psychiatry Neurosci. 2019;44(2):120-131. doi:10.1503/jpn.180032.DOI Google Scholar PubMed

Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda.

Stevenson A, Akena D, Stroud RE, et al. Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda. BMJ Open. 2019;9(2):e025469. doi:10.1136/bmjopen-2018-025469.DOI Google Scholar PubMed