Stanley Center for Psychiatric Research

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding.

Goode TD, Bernstein MX, Totty MS, et al. A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding. Neuron. 2026. doi:10.1016/j.neuron.2026.01.025DOI PubMed Google Scholar

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Wu SJ, Dai M, Yang SP, et al. Pyramidal neurons proportionately alter cortical interneuron subtypes. Nature. 2026. doi:10.1038/s41586-025-09996-8DOI PubMed Google Scholar

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus.

Mandell KAP, Simmons SK, Nadig A, et al. Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus. Translational psychiatry. 2025;15(1):345. doi:10.1038/s41398-025-03563-5DOI PubMed Google Scholar

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder.

Song BJ, Ge Y, Nicolella A, et al. Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder. Nature communications. 2025;16(1):10793. doi:10.1038/s41467-025-66504-2DOI PubMed Google Scholar

A concerted neuron-astrocyte program declines in ageing and schizophrenia.

Ling E, Nemesh J, Goldman M, et al. A concerted neuron-astrocyte program declines in ageing and schizophrenia. Nature. 2024. doi:10.1038/s41586-024-07109-5DOI PubMed Google Scholar

Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart.

Ma R, Conley SD, Kosicki M, et al. Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.11.20.24317557DOI PubMed Google Scholar

Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity.

Tervi A, Ramste M, Abner E, et al. Genetic and functional analysis of Raynaud’s syndrome implicates loci in vasculature and immunity. Cell genomics. 2024:100630. doi:10.1016/j.xgen.2024.100630DOI PubMed Google Scholar

Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice.

Farsi Z, Nicolella A, Simmons SK, et al. Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice. Neuron. 2023. doi:10.1016/j.neuron.2023.08.004DOI PubMed Google Scholar

Spatial atlas of the mouse central nervous system at molecular resolution.

Shi H, He Y, Zhou Y, et al. Spatial atlas of the mouse central nervous system at molecular resolution. Nature. 2023. doi:10.1038/s41586-023-06569-5DOI PubMed Google Scholar

Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.

Huang Q, Chen AT, Chan KY, et al. Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS biology. 2023;21(7):e3002112. doi:10.1371/journal.pbio.3002112DOI PubMed Google Scholar