Stanley Center for Psychiatric Research
Predicting functional effects of missense variants in voltage-gated sodium and calcium channels. Sci Transl Med. 2020;12(556). doi:10.1126/scitranslmed.aay6848.
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome. Sci Transl Med. 2020;12(544). doi:10.1126/scitranslmed.aam8572.
Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits. Transl Psychiatry. 2020;10(1):29. doi:10.1038/s41398-020-0685-1.
Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes. Nat Commun. 2019;10(1):4377. doi:10.1038/s41467-019-12372-6.
Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution. Science. 2019;363(6434):1463-1467. doi:10.1126/science.aaw1219.
. Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder. J Psychiatry Neurosci. 2019;44(2):120-131. doi:10.1503/jpn.180032.
Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda. BMJ Open. 2019;9(2):e025469. doi:10.1136/bmjopen-2018-025469.
Clinical implications of the proposed ICD-11 PTSD diagnostic criteria. Psychol Med. 2019;49(3):483-490. doi:10.1017/S0033291718001101.
Amygdalar activity predicts future incident diabetes independently of adiposity. Psychoneuroendocrinology. 2019;100:32-40. doi:10.1016/j.psyneuen.2018.09.024.
Contribution of rare and common variants to intellectual disability in a sub-isolate of Northern Finland. Nat Commun. 2019;10(1):410. doi:10.1038/s41467-018-08262-y.
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity. 2019;50(1):253-271.e6. doi:10.1016/j.immuni.2018.11.004.
The NeuroDev Study: Phenotypic and Genetic Characterization of Neurodevelopmental Disorders in Kenya and South Africa. Neuron. 2019;101(1):15-19. doi:10.1016/j.neuron.2018.12.016.
Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls - CORRIGENDUM. Psychol Med. 2019;49(2):351. doi:10.1017/S0033291718002945.
Reply to 'Selective effects of heterozygous protein-truncating variants'. Nat Genet. 2019;51(1):3-4. doi:10.1038/s41588-018-0301-y.
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet. 2019;51(1):63-75. doi:10.1038/s41588-018-0269-7.
Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia. Am J Psychiatry. 2019;176(1):29-35. doi:10.1176/appi.ajp.2018.17040467.
Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice. Biol Psychiatry. 2018;84(12):917-925. doi:10.1016/j.biopsych.2018.05.011.
Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder. Science. 2018;362(6420). doi:10.1126/science.aat6576.
. The ethics of global psychiatric genomics: Multilayered challenges to integrating genomics in global mental health and disability-A position paper of the Oxford Global Initiative in Neuropsychiatric GenEthics (NeuroGenE). Am J Med Genet B Neuropsychiatr Genet. 2018. doi:10.1002/ajmg.b.32697.
. Associations between childhood maltreatment and risk of myocardial infarction in adulthood: Results from the National Epidemiologic Survey on alcohol and Related Conditions. J Psychiatr Res. 2018. doi:10.1016/j.jpsychires.2018.12.001.
. The critical needs and challenges for genetic architecture studies in Africa. Curr Opin Genet Dev. 2018;53:113-120. doi:10.1016/j.gde.2018.08.005.
Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder. Epigenomics. 2018;10(12):1585-1601. doi:10.2217/epi-2018-0049.
Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018;136(6):857-872. doi:10.1007/s00401-018-1881-4.
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018;21(12):1656-1669. doi:10.1038/s41593-018-0275-1.
Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement. 2018;14(12):1580-1588. doi:10.1016/j.jalz.2018.01.017.
Posttraumatic stress disorder and incidence of thyroid dysfunction in women. Psychol Med. 2018:1-10. doi:10.1017/S0033291718003495.
. Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice. Sci Rep. 2018;8(1):17293. doi:10.1038/s41598-018-35716-6.
Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons. Development. 2018;145(22). doi:10.1242/dev.168617.
. Aggregated SOD1 causes selective death of cultured human motor neurons. Sci Rep. 2018;8(1):16393. doi:10.1038/s41598-018-34759-z.
Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations. Nat Genet. 2018;50(11):1600-1607. doi:10.1038/s41588-018-0231-8.
Guideline-based and bioinformatic reassessment of lesion-associated gene and variant pathogenicity in focal human epilepsies. Epilepsia. 2018;59(11):2145-2152. doi:10.1111/epi.14579.
Phenome-wide association studies across large population cohorts support drug target validation. Nat Commun. 2018;9(1):4285. doi:10.1038/s41467-018-06540-3.
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. Neuron. 2018;100(1):120-134.e6. doi:10.1016/j.neuron.2018.09.017.
. Microglia and the Brain: Complementary Partners in Development and Disease. Annu Rev Cell Dev Biol. 2018;34:523-544. doi:10.1146/annurev-cellbio-100616-060509.
Posttraumatic stress disorder and development of premenstrual syndrome in a longitudinal cohort of women. Arch Womens Ment Health. 2018. doi:10.1007/s00737-018-0916-0.
Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects. Nat Commun. 2018;9(1):4038. doi:10.1038/s41467-018-06159-4.
. New tricks for an ancient system: Physiological and pathological roles of complement in the CNS. Mol Immunol. 2018;102:3-13. doi:10.1016/j.molimm.2018.06.264.
Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018). Twin Res Hum Genet. 2018;21(5):394-397. doi:10.1017/thg.2018.46.
. Gene therapy for neurological disorders: progress and prospects. Nat Rev Drug Discov. 2018;17(10):767. doi:10.1038/nrd.2018.158.
Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol. 2018;217(10):3747-3765. doi:10.1083/jcb.201802057.
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk.
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk. Nat Genet. 2018;50(10):1483-1493. doi:10.1038/s41588-018-0196-7.
The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families. Cephalalgia. 2018;38(12):1849-1863. doi:10.1177/0333102418761041.
Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis. Transl Psychiatry. 2018;8(1):204. doi:10.1038/s41398-018-0229-0.
De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis. Cell Rep. 2018;24(13):3441-3454.e12. doi:10.1016/j.celrep.2018.08.082.
Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychol Med. 2018:1-8. doi:10.1017/S0033291718002039.
. Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells. Proc Natl Acad Sci U S A. 2018;115(36):E8368-E8377. doi:10.1073/pnas.1802568115.
Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study. Lancet Neurol. 2018;17(9):773-781. doi:10.1016/S1474-4422(18)30251-5.
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol Psychiatry. 2018. doi:10.1038/s41380-018-0112-7.
Genetic Influences on Patient-Oriented Outcomes in Traumatic Brain Injury: A Living Systematic Review of Non-Apolipoprotein E Single-Nucleotide Polymorphisms. J Neurotrauma. 2018. doi:10.1089/neu.2017.5583.
Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain. Cell. 2018;174(4):1015-1030.e16. doi:10.1016/j.cell.2018.07.028.
Molecular genetic overlap between migraine and major depressive disorder. Eur J Hum Genet. 2018;26(8):1202-1216. doi:10.1038/s41431-018-0150-2.
A synthetic-diploid benchmark for accurate variant-calling evaluation. Nat Methods. 2018;15(8):595-597. doi:10.1038/s41592-018-0054-7.
Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum. J Physiol. 2018;596(16):3695-3707. doi:10.1113/JP275936.
Rare coding variants in genes encoding GABA receptors in genetic generalised epilepsies: an exome-based case-control study. Lancet Neurol. 2018;17(8):699-708. doi:10.1016/S1474-4422(18)30215-1.
Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol. 2018;75(8):989-998. doi:10.1001/jamaneurol.2018.0821.
. Developing neurons are innately inclined to learn on the job. Nature. 2018;560(7716):39-40. doi:10.1038/d41586-018-05737-2.
. Genetics Sheds New Light on Congenital Hydrocephalus Biology. Neuron. 2018;99(2):246-247. doi:10.1016/j.neuron.2018.07.008.
Layer I Interneurons Sharpen Sensory Maps during Neonatal Development. Neuron. 2018;99(1):98-116.e7. doi:10.1016/j.neuron.2018.06.002.
Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function. Mol Psychiatry. 2018. doi:10.1038/s41380-018-0113-6.
. Viral Strategies for Targeting the Central and Peripheral Nervous Systems. Annu Rev Neurosci. 2018;41:323-348. doi:10.1146/annurev-neuro-080317-062048.
. Age at first birth in women is genetically associated with increased risk of schizophrenia. Sci Rep. 2018;8(1):10168. doi:10.1038/s41598-018-28160-z.
Toward Precision Medicine for Neurological and Neuropsychiatric Disorders. Cell Stem Cell. 2018;23(1):21-24. doi:10.1016/j.stem.2018.05.019.
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun. 2018;6(1):55. doi:10.1186/s40478-018-0555-8.
. Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry. 2018;57(26):3916-3924. doi:10.1021/acs.biochem.8b00367.
Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. J Clin Invest. 2018;128(7):3008-3023. doi:10.1172/JCI95231.
Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons. Nat Biomed Eng. 2018;2(7):540-554. doi:10.1038/s41551-018-0219-9.
De novo variants in neurodevelopmental disorders with epilepsy. Nat Genet. 2018;50(7):1048-1053. doi:10.1038/s41588-018-0143-7.
Types of Trauma, Posttraumatic Stress Disorder, and Academic Performance in a Population of University Students. J Nerv Ment Dis. 2018;206(7):507-512. doi:10.1097/NMD.0000000000000842.
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet. 2018;50(7):937-943. doi:10.1038/s41588-018-0155-3.
Comprehensive comparative analysis of 5'-end RNA-sequencing methods. Nat Methods. 2018;15(7):505-511. doi:10.1038/s41592-018-0014-2.
Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations. Nature. 2018;559(7714):350-355. doi:10.1038/s41586-018-0321-x.
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet. 2018;50(7):912-919. doi:10.1038/s41588-018-0152-6.
. Mixed-model association for biobank-scale datasets. Nat Genet. 2018;50(7):906-908. doi:10.1038/s41588-018-0144-6.
. Childhood interpersonal violence and adult alcohol, cannabis, and tobacco use disorders: variation by race/ethnicity?. Psychol Med. 2018;48(9):1540-1550. doi:10.1017/S0033291717003208.
Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. Nat Genet. 2018;50(7):1041-1047. doi:10.1038/s41588-018-0148-2.
Prevalence of rearrangements in the 22q11.2 region and population-based risk of neuropsychiatric and developmental disorders in a Danish population: a case-cohort study. Lancet Psychiatry. 2018;5(7):573-580. doi:10.1016/S2215-0366(18)30168-8.
Progress in Understanding and Treating SCN2A-Mediated Disorders. Trends Neurosci. 2018;41(7):442-456. doi:10.1016/j.tins.2018.03.011.
. Depressive Symptoms, Antidepressant Use, and Hypertension in Young Adulthood. Epidemiology. 2018;29(4):547-555. doi:10.1097/EDE.0000000000000840.
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes Dev. 2018;32(13-14):929-943. doi:10.1101/gad.313932.118.
Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotides. Genome Res. 2018;28(7):968-974. doi:10.1101/gr.231902.117.
GeNets: a unified web platform for network-based genomic analyses. Nat Methods. 2018;15(7):543-546. doi:10.1038/s41592-018-0039-6.
The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection. Cell. 2018;174(1):44-58.e17. doi:10.1016/j.cell.2018.04.019.
Analysis of shared heritability in common disorders of the brain. Science. 2018;360(6395). doi:10.1126/science.aap8757.
A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry. 2018;83(12):1044-1053. doi:10.1016/j.biopsych.2017.11.026.
Cell. 2018;173(7):1705-1715.e16. doi:10.1016/j.cell.2018.05.046.
Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum. Am J Hum Genet. 2018;102(6):1204-1211. doi:10.1016/j.ajhg.2018.05.002.
. Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood. Am J Hum Genet. 2018;102(6):1185-1194. doi:10.1016/j.ajhg.2018.03.021.
Traumatic stress and accelerated DNA methylation age: A meta-analysis. Psychoneuroendocrinology. 2018;92:123-134. doi:10.1016/j.psyneuen.2017.12.007.
A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease. Nat Neurosci. 2018;21(6):811-819. doi:10.1038/s41593-018-0154-9.
Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Elife. 2018;7. doi:10.7554/eLife.33385.
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Rep. 2018;23(8):2509-2523. doi:10.1016/j.celrep.2018.04.066.
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Cell. 2018;173(5):1265-1279.e19. doi:10.1016/j.cell.2018.03.037.
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron. 2018;98(4):743-753.e4. doi:10.1016/j.neuron.2018.04.014.
Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland. Am J Hum Genet. 2018;102(5):760-775. doi:10.1016/j.ajhg.2018.03.003.
Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits. Nat Genet. 2018;50(5):737-745. doi:10.1038/s41588-018-0108-x.
. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(5):693-698. doi:10.1038/s41588-018-0099-7.
Early Risk and Resiliency Factors Predict Chronic Posttraumatic Stress Disorder in Caregivers of Patients Admitted to a Neuroscience ICU. Crit Care Med. 2018;46(5):713-719. doi:10.1097/CCM.0000000000002988.
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa. Mol Psychiatry. 2018;23(5):1169-1180. doi:10.1038/mp.2017.88.
Distinguishing postpartum and antepartum depressive trajectories in a large population-based cohort: the impact of exposure to adversity and offspring gender. Psychol Med. 2018;48(7):1139-1147. doi:10.1017/S0033291717002549.
An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder. Nat Genet. 2018;50(5):727-736. doi:10.1038/s41588-018-0107-y.
Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study.
Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study. Nat Commun. 2018;9(1):1612. doi:10.1038/s41467-018-03910-9.
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment. ACS Chem Biol. 2018;13(4):1038-1047. doi:10.1021/acschembio.8b00168.
Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Mol Cell. 2018;70(2):211-227.e8. doi:10.1016/j.molcel.2018.03.012.
In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images. Cell. 2018;173(3):792-803.e19. doi:10.1016/j.cell.2018.03.040.
. A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors. ACS Chem Neurosci. 2018;9(4):684-690. doi:10.1021/acschemneuro.7b00485.
. Thalamic Reticular Dysfunction as a Circuit Endophenotype in Neurodevelopmental Disorders. Neuron. 2018;98(2):282-295. doi:10.1016/j.neuron.2018.03.021.
The ethics of experimenting with human brain tissue. Nature. 2018;556(7702):429-432. doi:10.1038/d41586-018-04813-x.
Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nat Genet. 2018;50(4):538-548. doi:10.1038/s41588-018-0092-1.
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters. Nat Chem Biol. 2018;14(4):352-360. doi:10.1038/s41589-018-0004-9.
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nat Genet. 2018;50(4):621-629. doi:10.1038/s41588-018-0081-4.
Developmental diversification of cortical inhibitory interneurons. Nature. 2018;555(7697):457-462. doi:10.1038/nature25999.
Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice. Neuron. 2018;97(6):1394. doi:10.1016/j.neuron.2018.03.006.
Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins. Cell Rep. 2018;22(12):3351-3361. doi:10.1016/j.celrep.2018.02.081.
Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers. Sci Rep. 2018;8(1):4467. doi:10.1038/s41598-018-22790-z.
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018;10(431). doi:10.1126/scitranslmed.aam8460.
Advancing neuropsychiatric genetics training and collaboration in Africa. Lancet Glob Health. 2018;6(3):e246-e247. doi:10.1016/S2214-109X(18)30042-1.
Posttraumatic stress disorder onset and inflammatory and endothelial function biomarkers in women. Brain Behav Immun. 2018;69:203-209. doi:10.1016/j.bbi.2017.11.013.
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Mol Psychiatry. 2018;23(3):666-673. doi:10.1038/mp.2017.77.
Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data. Elife. 2018;7. doi:10.7554/eLife.28728.
Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism. Cell Rep. 2018;22(7):1695-1709. doi:10.1016/j.celrep.2018.01.007.
Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat Genet. 2018;50(2):229-237. doi:10.1038/s41588-017-0009-4.
Recovery from DSM-IV post-traumatic stress disorder in the WHO World Mental Health surveys. Psychol Med. 2018;48(3):437-450. doi:10.1017/S0033291717001817.
Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study. Cephalalgia. 2018;38(2):312-322. doi:10.1177/0333102417690111.
. Windows of opportunity: timing in neurodevelopmental disorders. Curr Opin Neurobiol. 2018;48:59-63. doi:10.1016/j.conb.2017.10.014.
ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties. Mol Psychiatry. 2018;23(2):263-270. doi:10.1038/mp.2016.198.
. Using intracellular markers to identify a novel set of surface markers for live cell purification from a heterogeneous hIPSC culture. Sci Rep. 2018;8(1):804. doi:10.1038/s41598-018-19291-4.
. The Intergenerational Impact of Prenatal Stress: Time to Focus on Prevention?. Biol Psychiatry. 2018;83(2):92-93. doi:10.1016/j.biopsych.2017.11.004.
Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon. Development. 2018;145(1). doi:10.1242/dev.154583.
. Organoids required! A new path to understanding human brain development and disease. Nat Methods. 2018;15(1):27-29. doi:10.1038/nmeth.4557.
NetSig: network-based discovery from cancer genomes. Nat Methods. 2018;15(1):61-66. doi:10.1038/nmeth.4514.
Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat Neurosci. 2018;21(1):120-129. doi:10.1038/s41593-017-0029-5.
Post-traumatic stress disorder associated with sexual assault among women in the WHO World Mental Health Surveys. Psychol Med. 2018;48(1):155-167. doi:10.1017/S0033291717001593.
. Report on the National Eye Institute's Audacious Goals Initiative: Creating a Cellular Environment for Neuroregeneration. eNeuro. 2018;5(2). doi:10.1523/ENEURO.0035-18.2018.
. Using Droplet Digital PCR to Analyze Allele-Specific RNA Expression. Methods Mol Biol. 2018;1768:401-422. doi:10.1007/978-1-4939-7778-9_23.
. Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease. Curr Top Dev Biol. 2018;129:99-122. doi:10.1016/bs.ctdb.2018.03.002.
Using Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration. eNeuro. 2018;5(3). doi:10.1523/ENEURO.0001-18.2018.
. Analyzing Copy Number Variation with Droplet Digital PCR. Methods Mol Biol. 2018;1768:143-160. doi:10.1007/978-1-4939-7778-9_9.
Reproductive period and epigenetic modifications of the oxidative phosphorylation pathway in the human prefrontal cortex. PLoS One. 2018;13(7):e0199073. doi:10.1371/journal.pone.0199073.
. Functional Topography and Development of Inhibitory Reticulothalamic Barreloid Projections. Front Neuroanat. 2018;12:87. doi:10.3389/fnana.2018.00087.
. Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes. Methods Mol Biol. 2018;1787:235-252. doi:10.1007/978-1-4939-7847-2_18.
. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Mol Neurobiol. 2017;54(10):8090-8109. doi:10.1007/s12035-016-0261-0.
A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017;216(11):3655-3675. doi:10.1083/jcb.201705085.
. Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1. J Neurosci. 2017;37(44):10541-10553. doi:10.1523/JNEUROSCI.2679-16.2017.
RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114(41):E8788-E8797. doi:10.1073/pnas.1714175114.
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017;13(10):1102-1108. doi:10.1038/nchembio.2458.
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017;357(6356):1156-1160. doi:10.1126/science.aah5043.
Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease. J Neurosci. 2017;37(37):9037-9053. doi:10.1523/JNEUROSCI.0811-17.2017.
. Microglia emerge as central players in brain disease. Nat Med. 2017;23(9):1018-1027. doi:10.1038/nm.4397.
Reconstructing cell cycle and disease progression using deep learning. Nat Commun. 2017;8(1):463. doi:10.1038/s41467-017-00623-3.
Data-analysis strategies for image-based cell profiling. Nat Methods. 2017;14(9):849-863. doi:10.1038/nmeth.4397.
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem Cell Reports. 2017;9(2):667-680. doi:10.1016/j.stemcr.2017.06.008.
. Animal models for neuropsychiatric disorders: prospects for circuit intervention. Curr Opin Neurobiol. 2017;45:59-65. doi:10.1016/j.conb.2017.03.010.
Erratum: Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2017;22(8):1223. doi:10.1038/mp.2016.246.
. InDrops and Drop-seq technologies for single-cell sequencing. Lab Chip. 2017;17(15):2540-2541. doi:10.1039/c7lc90070h.
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem Cell Reports. 2017;9(1):1-4. doi:10.1016/j.stemcr.2017.05.029.
. The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression. J Neurochem. 2017;142(1):89-102. doi:10.1111/jnc.14045.
Corrigendum: Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci. 2017;20(7):1033. doi:10.1038/nn0717-1033b.
Addendum: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2017;20(7):1033. doi:10.1038/nn0717-1033d.
Corrigendum: A viral strategy for targeting and manipulating interneurons across vertebrate species.
Corrigendum: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2017;20(7):1033. doi:10.1038/nn0717-1033c.
Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource. Nat Commun. 2017;8:15930. doi:10.1038/ncomms15930.
Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. J Med Chem. 2017;60(12):4983-5001. doi:10.1021/acs.jmedchem.7b00395.
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017;9(392). doi:10.1126/scitranslmed.aaf6295.
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature. 2017;545(7653):229-233. doi:10.1038/nature22312.
Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545(7652):48-53. doi:10.1038/nature22047.
. Genetic and activity-dependent mechanisms underlying interneuron diversity. Nat Rev Neurosci. 2017;18(5):299-309. doi:10.1038/nrn.2017.30.
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism. J Clin Invest. 2017;127(5):1978-1990. doi:10.1172/JCI87997.
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. Cell Rep. 2017;19(2):335-350. doi:10.1016/j.celrep.2017.03.052.
Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia. Neuron. 2017;94(1):138-152.e5. doi:10.1016/j.neuron.2017.03.017.
Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts. J Pharmacol Exp Ther. 2017;361(1):140-150. doi:10.1124/jpet.116.237701.
. The Path to New Therapies for Schizophrenia and Bipolar Illness. FASEB J. 2017;31(4):1254-1259. doi:10.1096/fj.201700028.
. SHANK proteins: roles at the synapse and in autism spectrum disorder. Nat Rev Neurosci. 2017;18(3):147-157. doi:10.1038/nrn.2016.183.
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. Mol Psychiatry. 2017;22(3):417-429. doi:10.1038/mp.2016.98.
A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017;20(3):484-496. doi:10.1038/nn.4495.
Comparative Analysis Highlights Variable Genome Content of Wheat Rusts and Divergence of the Mating Loci. G3 (Bethesda). 2017;7(2):361-376. doi:10.1534/g3.116.032797.
. Editorial overview: Developmental neuroscience 2017. Curr Opin Neurobiol. 2017;42:A1-A4. doi:10.1016/j.conb.2017.01.003.
. Studying human disease using human neurons. Brain Res. 2017;1656:40-48. doi:10.1016/j.brainres.2016.03.051.
Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541(7638):481-487. doi:10.1038/nature21029.
. Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function. Methods Mol Biol. 2017;1538:155-167. doi:10.1007/978-1-4939-6688-2_12.
A scored human protein-protein interaction network to catalyze genomic interpretation. Nat Methods. 2017;14(1):61-64. doi:10.1038/nmeth.4083.
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat Genet. 2017;49(1):27-35. doi:10.1038/ng.3725.
Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection. Cell Stem Cell. 2016;19(6):703-708. doi:10.1016/j.stem.2016.11.011.
A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2016;19(12):1743-1749. doi:10.1038/nn.4430.
Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome. Elife. 2016;5. doi:10.7554/eLife.19090.
Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome. Proc Natl Acad Sci U S A. 2016;113(46):E7287-E7296. doi:10.1073/pnas.1615330113.
Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia. Cancer Cell. 2016;30(5):750-763. doi:10.1016/j.ccell.2016.10.005.
Balancing selection shapes density-dependent foraging behaviour. Nature. 2016;539(7628):254-258. doi:10.1038/nature19848.
. Increasing the neurological-disease toolbox using iPSC-derived microglia. Nat Med. 2016;22(11):1206-1207. doi:10.1038/nm.4226.
. The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat Med. 2016;22(11):1220-1228. doi:10.1038/nm.4214.
. Back to basics: luring industry back into neuroscience. Nat Neurosci. 2016;19(11):1383-1384. doi:10.1038/nn.4429.
. Research Into Brain Disorders as an Example of Targeted Science. JAMA. 2016;316(16):1673-1674. doi:10.1001/jama.2016.12412.
. A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity. Sci Rep. 2016;6:34233. doi:10.1038/srep34233.
Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding.
Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding. Elife. 2016;5. doi:10.7554/eLife.18716.
. Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?. Biol Psychiatry. 2016;80(8):599-608. doi:10.1016/j.biopsych.2015.10.003.
Activity of caffeic acid phenethyl ester in Caenorhabditis elegans. Future Med Chem. 2016. doi:10.4155/fmc-2016-0085.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg Med Chem. 2016;24(18):4008-4015. doi:10.1016/j.bmc.2016.06.040.
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2016;21(9):1290-7. doi:10.1038/mp.2015.165.
. Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Res. 2016;17(2):430-432. doi:10.1016/j.scr.2016.09.009.
. Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Res. 2016;17(2):441-443. doi:10.1016/j.scr.2016.09.008.
Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci. 2016;19(9):1123-30. doi:10.1038/nn.4362.
Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Cell. 2016;166(5):1295-1307.e21. doi:10.1016/j.cell.2016.07.041.
Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016;166(5):1308-1323.e30. doi:10.1016/j.cell.2016.07.054.
. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2016;38:5B.6.1-5B.6.60. doi:10.1002/cpsc.15.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016;55(33):9601-5. doi:10.1002/anie.201603797.
Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons. Neuropharmacology. 2016;107:396-410. doi:10.1016/j.neuropharm.2016.03.037.
Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife. 2016;5. doi:10.7554/eLife.15224.
. Microglia: Phagocytosing to Clear, Sculpt, and Eliminate. Dev Cell. 2016;38(2):126-8. doi:10.1016/j.devcel.2016.07.006.
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 2016;11(7):1952-63. doi:10.1021/acschembio.6b00306.
Unbiased Deep Sequencing of RNA Viruses from Clinical Samples. J Vis Exp. 2016;(113). doi:10.3791/54117.
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet. 2016;48(7):803-10. doi:10.1038/ng.3572.
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry. 2016;73(7):695-704. doi:10.1001/jamapsychiatry.2016.0350.
A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016;534(7608):538-43. doi:10.1038/nature18283.
Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nat Commun. 2016;7:12019. doi:10.1038/ncomms12019.
Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System. Stem Cell Reports. 2016;6(6):993-1008. doi:10.1016/j.stemcr.2016.05.010.
Exome Sequencing of Familial Bipolar Disorder. JAMA Psychiatry. 2016;73(6):590-7. doi:10.1001/jamapsychiatry.2016.0251.
. Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers. J Neurosci. 2016;36(21):5709-23. doi:10.1523/JNEUROSCI.4366-15.2016.
Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies. Sci Rep. 2016;6:25888. doi:10.1038/srep25888.
Adult axolotls can regenerate original neuronal diversity in response to brain injury. Elife. 2016;5. doi:10.7554/eLife.13998.
Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016;352(6286):712-716. doi:10.1126/science.aad8373.
. Neurobiology of social behavior abnormalities in autism and Williams syndrome. Nat Neurosci. 2016;19(6):647-55. doi:10.1038/nn.4276.
. Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice. Nature. 2016;532(7597):58-63. doi:10.1038/nature17427.
Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016;19(4):542-53. doi:10.1038/nn.4273.
Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nat Commun. 2016;7:10962. doi:10.1038/ncomms10962.
. Stressed out? Healing Tips for Newly Reprogrammed Neurons. Cell Stem Cell. 2016;18(3):297-9. doi:10.1016/j.stem.2016.02.008.
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature. 2016;530(7591):481-4. doi:10.1038/nature16971.
Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts. Nat Commun. 2016;7:10740. doi:10.1038/ncomms10740.
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol. 2016;11(2):363-74. doi:10.1021/acschembio.5b00640.
. Cellular neuroscience. Differences among astrocytes. Science. 2016;351(6275):813. doi:10.1126/science.aaf2849.
Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016;36(7):2247-60. doi:10.1523/JNEUROSCI.2528-15.2016.
Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530(7589):177-83. doi:10.1038/nature16549.
. CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors. Curr Biol. 2016;26(3):296-308. doi:10.1016/j.cub.2015.11.071.
. Seq-ing the cortex one neuron at a time. Nat Neurosci. 2016;19(2):179-81. doi:10.1038/nn.4230.
. New insights on the role of microglia in synaptic pruning in health and disease. Curr Opin Neurobiol. 2016;36:128-34. doi:10.1016/j.conb.2015.12.004.
. Diversity Matters: A Revised Guide to Myelination. Trends Cell Biol. 2016;26(2):135-147. doi:10.1016/j.tcb.2015.09.002.
Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3. Mol Psychiatry. 2016;21(2):159-68. doi:10.1038/mp.2015.173.
Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. J Biol Chem. 2016;291(4):1948-56. doi:10.1074/jbc.M115.705319.
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects. Neuron. 2016;89(1):147-62. doi:10.1016/j.neuron.2015.11.023.
Striatal magnetic resonance spectroscopy abnormalities in young adult SAPAP3 knockout mice. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016;1(1):39-48. doi:10.1016/j.bpsc.2015.10.001.
. Learning From Animal Models of Obsessive-Compulsive Disorder. Biol Psychiatry. 2016;79(1):7-16. doi:10.1016/j.biopsych.2015.04.020.
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015;5(6):933-945. doi:10.1016/j.stemcr.2015.10.011.
. Tracks through the genome to physiological events. Exp Physiol. 2015;100(12):1429-40. doi:10.1113/EP085129.
. Homeotic Transformations of Neuronal Cell Identities. Trends Neurosci. 2015;38(12):751-62. doi:10.1016/j.tins.2015.10.005.
Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy. Cell Stem Cell. 2015;17(5):569-84. doi:10.1016/j.stem.2015.08.003.
Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons. Neuron. 2015;88(3):475-83. doi:10.1016/j.neuron.2015.10.006.
. Do glia drive synaptic and cognitive impairment in disease?. Nat Neurosci. 2015;18(11):1539-1545. doi:10.1038/nn.4142.
. Microglia: Dynamic Mediators of Synapse Development and Plasticity. Trends Immunol. 2015;36(10):605-13. doi:10.1016/j.it.2015.08.008.
Genome Sequences of Three Phytopathogenic Species of the Magnaporthaceae Family of Fungi. G3 (Bethesda). 2015;5(12):2539-45. doi:10.1534/g3.115.020057.
Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. J Neurosci. 2015;35(38):13029-42. doi:10.1523/JNEUROSCI.1698-15.2015.
. Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders. Cell Stem Cell. 2015;17(3):253-4. doi:10.1016/j.stem.2015.08.013.
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nat Methods. 2015;12(9):885-92. doi:10.1038/nmeth.3507.
. Modeling psychiatric disorders for developing effective treatments. Nat Med. 2015;21(9):979-88. doi:10.1038/nm.3935.
. Microglia function during brain development: New insights from animal models. Brain Res. 2015;1617:7-17. doi:10.1016/j.brainres.2014.11.032.
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus. Cell. 2015;162(4):738-50. doi:10.1016/j.cell.2015.07.020.
Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia. Transl Psychiatry. 2015;5:e607. doi:10.1038/tp.2015.99.
. Microglia Function in Central Nervous System Development and Plasticity. Cold Spring Harb Perspect Biol. 2015;7(10):a020545. doi:10.1101/cshperspect.a020545.
. From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell Stem Cell. 2015;17(1):8-10. doi:10.1016/j.stem.2015.06.013.
. Focus on induced pluripotency and cellular reprogramming. EMBO J. 2015;34(11):1435. doi:10.15252/embj.201591615.
Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain. Proc Natl Acad Sci U S A. 2015;112(22):6855-62. doi:10.1073/pnas.1411263112.
Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus. Cell Rep. 2015;11(6):875-883. doi:10.1016/j.celrep.2015.04.007.
Brains, genes, and primates. Neuron. 2015;86(3):617-31. doi:10.1016/j.neuron.2015.03.021.
CRISPR germline engineering--the community speaks. Nat Biotechnol. 2015;33(5):478-86. doi:10.1038/nbt.3227.
Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism. Chem Biol. 2015;22(4):439-445. doi:10.1016/j.chembiol.2015.03.014.
. Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages. Immunity. 2015;42(4):600-2. doi:10.1016/j.immuni.2015.04.002.
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell. 2015;160(6):1246-60. doi:10.1016/j.cell.2015.02.038.
. Seven actionable strategies for advancing women in science, engineering, and medicine. Cell Stem Cell. 2015;16(3):221-4. doi:10.1016/j.stem.2015.02.012.
Discovery of novel rhabdoviruses in the blood of healthy individuals from West Africa. PLoS Negl Trop Dis. 2015;9(3):e0003631. doi:10.1371/journal.pntd.0003631.
Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development. 2015;142(4):633-43. doi:10.1242/dev.117978.
NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma. Mol Cancer. 2015;14:2. doi:10.1186/1476-4598-14-2.
. Striatal circuits, habits, and implications for obsessive-compulsive disorder. Curr Opin Neurobiol. 2015;30:59-65. doi:10.1016/j.conb.2014.08.008.
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015;20(2):162-9. doi:10.1038/mp.2014.143.
Erratum: Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015;20(2):284. doi:10.1038/mp.2014.181.
. Cerebral cortex assembly: generating and reprogramming projection neuron diversity. Trends Neurosci. 2015;38(2):117-25. doi:10.1016/j.tins.2014.11.003.
The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015;6:6121. doi:10.1038/ncomms7121.
Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons. J Neurosci. 2015;35(3):1291-306. doi:10.1523/JNEUROSCI.2126-14.2015.
DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 2015;85(2):275-288. doi:10.1016/j.neuron.2014.12.024.
A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015;33(1):58-63. doi:10.1038/nbt.3070.
. Building blocks of the cerebral cortex: from development to the dish. Wiley Interdiscip Rev Dev Biol. 2015;4(5):529-44. doi:10.1002/wdev.192.
. Generating neuronal diversity in the mammalian cerebral cortex. Annu Rev Cell Dev Biol. 2015;31:699-720. doi:10.1146/annurev-cellbio-100814-125353.
Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015;18(1):17-24. doi:10.1038/nn.3886.
Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015;6(1):804-815. doi:10.1039/C4SC02130D.
. A perspective on stem cell modeling of amyotrophic lateral sclerosis. Cell Cycle. 2015;14(23):3679-88. doi:10.1080/15384101.2015.1093712.
Astrocytes refine cortical connectivity at dendritic spines. Elife. 2014;3. doi:10.7554/eLife.04047.
Genetic variation in human DNA replication timing. Cell. 2014;159(5):1015-1026. doi:10.1016/j.cell.2014.10.025.
iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell Rep. 2014;9(4):1173-82. doi:10.1016/j.celrep.2014.10.023.
Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition. J Neurosci. 2014;34(43):14328-37. doi:10.1523/JNEUROSCI.1010-14.2014.
An unbiased approach to identify endogenous substrates of "histone" deacetylase 8. ACS Chem Biol. 2014;9(10):2210-6. doi:10.1021/cb500492r.
In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. J Med Chem. 2014;57(19):7999-8009. doi:10.1021/jm500872p.
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Mol Psychiatry. 2014;19(9):1017-24. doi:10.1038/mp.2013.138.
. Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron. 2014;83(4):894-905. doi:10.1016/j.neuron.2014.06.033.
Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. Science. 2014;345(6197):688-93. doi:10.1126/science.1250127.
. Genetic validation of a therapeutic target in a mouse model of ALS. Sci Transl Med. 2014;6(248):248ra104. doi:10.1126/scitranslmed.3009351.
. Brains in metamorphosis: reprogramming cell identity within the central nervous system. Curr Opin Neurobiol. 2014;27:208-14. doi:10.1016/j.conb.2014.04.007.
Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014;17(8):1046-54. doi:10.1038/nn.3757.
Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014;10(8):632-639. doi:10.1038/nchembio.1552.
Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'. Mol Psychiatry. 2014;19(8):859-61. doi:10.1038/mp.2013.125.
DNA methylation dynamics of the human preimplantation embryo. Nature. 2014;511(7511):611-5. doi:10.1038/nature13581.
Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. ACS Chem Neurosci. 2014;5(7):588-96. doi:10.1021/cn500021p.
Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure. J Virol. 2014;88(13):7286-93. doi:10.1128/JVI.00038-14.
Copy number variation in schizophrenia in Sweden. Mol Psychiatry. 2014;19(7):762-73. doi:10.1038/mp.2014.40.
. Studies toward the total synthesis of dihydrolycolucine. Preparation of AB and CEF ring fragments. J Org Chem. 2014;79(12):5740-5. doi:10.1021/jo500878v.
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet. 2014;23(12):3316-26. doi:10.1093/hmg/ddu025.
Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses. Cell Rep. 2014;7(5):1601-1613. doi:10.1016/j.celrep.2014.04.047.
. An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. J Vis Exp. 2014;(88). doi:10.3791/51482.
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014;14(6):781-95. doi:10.1016/j.stem.2014.03.004.
Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families. Am J Hum Genet. 2014;94(6):870-83. doi:10.1016/j.ajhg.2014.05.004.
. Genome-scale neurogenetics: methodology and meaning. Nat Neurosci. 2014;17(6):756-63. doi:10.1038/nn.3716.
Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment. Stem Cells Transl Med. 2014;3(5):575-85. doi:10.5966/sctm.2013-0153.
Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. Biol Psychiatry. 2014;75(8):623-30. doi:10.1016/j.biopsych.2013.01.008.
Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.
Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014;7(1):1-11. doi:10.1016/j.celrep.2014.03.019.
Selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions. Curr Biol. 2014;24(6):693-8. doi:10.1016/j.cub.2014.02.011.
Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder. Genome Biol. 2014;15(3):R25. doi:10.1186/gb-2014-15-3-r25.
A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506(7487):185-90. doi:10.1038/nature12975.
De novo mutations in schizophrenia implicate synaptic networks. Nature. 2014;506(7487):179-84. doi:10.1038/nature12929.
. Nanog-independent reprogramming to iPSCs with canonical factors. Stem Cell Reports. 2014;2(2):119-26. doi:10.1016/j.stemcr.2013.12.010.
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 2014;81(3):536-543. doi:10.1016/j.neuron.2013.12.018.
. How to make spinal motor neurons. Development. 2014;141(3):491-501. doi:10.1242/dev.097410.
Development of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neurons. J Biomol Screen. 2014;19(2):205-14. doi:10.1177/1087057113505905.
. Development-inspired reprogramming of the mammalian central nervous system. Science. 2014;343(6170):1239882. doi:10.1126/science.1239882.
Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell. 2014;156(1-2):261-76. doi:10.1016/j.cell.2013.12.020.
Flow of cortical activity underlying a tactile decision in mice. Neuron. 2014;81(1):179-94. doi:10.1016/j.neuron.2013.10.020.
. Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics. Methods Mol Biol. 2014;1183:221-42. doi:10.1007/978-1-4939-1096-0_14.
Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA. PLoS One. 2014;9(5):e96094. doi:10.1371/journal.pone.0096094.
. The role of muscle microRNAs in repairing the neuromuscular junction. PLoS One. 2014;9(3):e93140. doi:10.1371/journal.pone.0093140.
. Recombineering strategies for developing next generation BAC transgenic tools for optogenetics and beyond. Front Behav Neurosci. 2014;8:111. doi:10.3389/fnbeh.2014.00111.
Enhanced methods for unbiased deep sequencing of Lassa and Ebola RNA viruses from clinical and biological samples. Genome Biol. 2014;15(11):519. doi:10.1186/PREACCEPT-1698056557139770.
Selective HDAC inhibition for the disruption of latent HIV-1 infection. PLoS One. 2014;9(8):e102684. doi:10.1371/journal.pone.0102684.
Fast modulation of visual perception by basal forebrain cholinergic neurons. Nat Neurosci. 2013;16(12):1857-1863. doi:10.1038/nn.3552.
. Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Proc Natl Acad Sci U S A. 2013;110(47):E4548-56. doi:10.1073/pnas.1318860110.
. Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology. Neuron. 2013;80(3):578-87. doi:10.1016/j.neuron.2013.10.046.
. Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience. Behav Brain Res. 2013;255:3-18. doi:10.1016/j.bbr.2013.02.037.
. Small molecule inhibitors of zinc-dependent histone deacetylases. Neurotherapeutics. 2013;10(4):589-604. doi:10.1007/s13311-013-0226-1.
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013;45(10):1150-9. doi:10.1038/ng.2742.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013;45(9):984-94. doi:10.1038/ng.2711.
. Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia. Future Med Chem. 2013;5(13):1491-508. doi:10.4155/fmc.13.141.
FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neurosci Lett. 2013;550:119-24. doi:10.1016/j.neulet.2013.06.016.
. Validating therapeutic targets through human genetics. Nat Rev Drug Discov. 2013;12(8):581-94. doi:10.1038/nrd4051.
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex. J Neurosci. 2013;33(27):10938-49. doi:10.1523/JNEUROSCI.5362-12.2013.
Class I HDAC imaging using [ (3)H]CI-994 autoradiography. Epigenetics. 2013;8(7):756-64. doi:10.4161/epi.25202.
ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domains. J Neurosci. 2013;33(25):10427-38. doi:10.1523/JNEUROSCI.0395-13.2013.
Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013;56(11):4816-20. doi:10.1021/jm400390r.
Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2013;110(24):9806-11. doi:10.1073/pnas.1301509110.
. Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science. 2013;340(6137):1243-6. doi:10.1126/science.1232380.
Optical inhibition of motor nerve and muscle activity in vivo. Muscle Nerve. 2013;47(6):916-21. doi:10.1002/mus.23696.
Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chem Biol. 2013;20(5):713-25. doi:10.1016/j.chembiol.2013.03.020.
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem. 2013;56(4):1772-6. doi:10.1021/jm301355j.
Cortical control of affective networks. J Neurosci. 2013;33(3):1116-29. doi:10.1523/JNEUROSCI.0092-12.2013.
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS One. 2013;8(8):e71323. doi:10.1371/journal.pone.0071323.
Next-generation transgenic mice for optogenetic analysis of neural circuits. Front Neural Circuits. 2013;7:160. doi:10.3389/fncir.2013.00160.
Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. Am J Nucl Med Mol Imaging. 2013;4(1):29-38.
Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Cell Rep. 2012;2(5):1329-39. doi:10.1016/j.celrep.2012.09.030.
Imaging neural activity using Thy1-GCaMP transgenic mice. Neuron. 2012;76(2):297-308. doi:10.1016/j.neuron.2012.07.011.
. Cellular and synaptic network defects in autism. Curr Opin Neurobiol. 2012;22(5):866-72. doi:10.1016/j.conb.2012.02.015.
Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries. J Org Chem. 2012;77(17):7187-211. doi:10.1021/jo300974j.
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry. 2012;17(9):880-6. doi:10.1038/mp.2012.73.
Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron. 2012;75(4):675-87. doi:10.1016/j.neuron.2012.06.023.
. Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice. J Neurosci. 2012;32(32):10887-94. doi:10.1523/JNEUROSCI.1732-12.2012.
Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. Chem Biol. 2012;19(6):669-73. doi:10.1016/j.chembiol.2012.05.010.
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. Proc Natl Acad Sci U S A. 2012;109(14):5364-9. doi:10.1073/pnas.1201079109.
. A transcription activator-like effector toolbox for genome engineering. Nat Protoc. 2012;7(1):171-92. doi:10.1038/nprot.2011.431.
Discovery of Potent and Highly Selective Inhibitors of GSK3b. Bethesda, MD: National Center for Biotechnology Information (US); 2012. Available at: https://www.ncbi.nlm.nih.gov/books/NBK133436/.
. Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders. Annu Rev Neurosci. 2012;35:49-71. doi:10.1146/annurev-neuro-062111-150442.
. Imaging synaptic inhibition with the genetically encoded chloride indicator Clomeleon. Cold Spring Harb Protoc. 2011;2011(12):1492-7. doi:10.1101/pdb.prot066985.
. Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics. Curr Opin Neurobiol. 2011;21(6):842-8. doi:10.1016/j.conb.2011.04.010.
. Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. J Neurosci. 2011;31(46):16685-91. doi:10.1523/JNEUROSCI.2533-11.2011.
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011;480(7377):372-5. doi:10.1038/nature10594.
. Unfolding neurodevelopmental disorders: found in translation. Nat Med. 2011;17(11):1352-3. doi:10.1038/nm.2553.
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Mol Psychiatry. 2011;16(11):1117-29. doi:10.1038/mp.2010.96.
. SnapShot: Autism and the synapse. Cell. 2011;147(3):706, 706.e1. doi:10.1016/j.cell.2011.10.015.
Advancing drug discovery for schizophrenia. Ann N Y Acad Sci. 2011;1236:30-43. doi:10.1111/j.1749-6632.2011.06216.x.
The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biol Ther. 2011;12(6):484-93. doi:10.4161/cbt.12.6.15956.
. Neuroscience: When lights take the circuits out. Nature. 2011;477(7363):165-6. doi:10.1038/477165a.
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods. 2011;8(9):745-52.
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chem Biol. 2011;18(7):891-906. doi:10.1016/j.chembiol.2011.03.017.
. Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles. Nat Neurosci. 2011;14(9):1118-20. doi:10.1038/nn.2880.
. Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. J Neurosci. 2011;31(26):9563-73. doi:10.1523/JNEUROSCI.1701-11.2011.
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology. 2011;36(7):1397-411. doi:10.1038/npp.2011.24.
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature. 2011;472(7344):437-42. doi:10.1038/nature09965.
. Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders. J Child Psychol Psychiatry. 2011;52(4):442-75. doi:10.1111/j.1469-7610.2011.02380.x.
Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron. 2011;69(3):445-52. doi:10.1016/j.neuron.2010.12.038.
A system for performing high throughput assays of synaptic function. PLoS One. 2011;6(10):e25999. doi:10.1371/journal.pone.0025999.
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry. 2011;16(1):2-4. doi:10.1038/mp.2009.107.
Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell. 2010;18(5):436-47. doi:10.1016/j.ccr.2010.10.022.
Medicine. The future of psychiatric research: genomes and neural circuits. Science. 2010;327(5973):1580-1. doi:10.1126/science.1188654.
Characterization of plant-derived saponin natural products against Candida albicans. ACS Chem Biol. 2010;5(3):321-32. doi:10.1021/cb900243b.
Support of association between BRD1 and both schizophrenia and bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet. 2010;153B(2):582-591. doi:10.1002/ajmg.b.31023.
. Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling. ACS Chem Neurosci. 2010;1(4):325-342. doi:10.1021/cn900046a.
Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay. PLoS One. 2009;4(9):e7025. doi:10.1371/journal.pone.0007025.
. Tripping the HCN breaker. Neuron. 2009;62(6):747-50. doi:10.1016/j.neuron.2009.06.003.
A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder. Am J Psychiatry. 2009;166(6):718-25. doi:10.1176/appi.ajp.2009.08111633.
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet. 2009;5(6):e1000534. doi:10.1371/journal.pgen.1000534.
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008;40(9):1056-8. doi:10.1038/ng.209.
Whole-genome association study of bipolar disorder. Mol Psychiatry. 2008;13(6):558-69. doi:10.1038/sj.mp.4002151.
. Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia. Am J Hum Genet. 2006;79(5):903-9. doi:10.1086/508942.
. Recurrence risks for schizophrenia in a Swedish national cohort. Psychol Med. 2006;36(10):1417-25. doi:10.1017/S0033291706008385.
A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase. J Biomol Screen. 2006;11(5):481-7. doi:10.1177/1087057106288181.
. Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations. Biol Psychiatry. 2006;59(11):1039-45. doi:10.1016/j.biopsych.2006.02.022.
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006;16(4):964-8. doi:10.1016/j.bmcl.2005.10.088.
. Cure therapeutics and strategic prevention: raising the bar for mental health research. Mol Psychiatry. 2006;11(1):11-7. doi:10.1038/sj.mp.4001777.
. Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?. Harv Rev Psychiatry. 2006;14(2):64-77. doi:10.1080/10673220600642960.
Anthrax lethal factor inhibition. Proc Natl Acad Sci U S A. 2005;102(22):7958-63. doi:10.1073/pnas.0502159102.
Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex. Neuron. 2005;45(6):861-72. doi:10.1016/j.neuron.2005.02.006.
. Program to improve cognitive functioning in patients with schizophrenia: reflections. Schizophr Res. 2004;72(1):75-7. doi:10.1016/j.schres.2004.09.005.
. High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors. J Biomol Screen. 2004;9(2):132-40. doi:10.1177/1087057103261039.
. Effect of pH on ionic exchange and function in rat and rabbit myocardium. Am J Physiol. 1975;229(3):570-81.