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Stanley Center for Psychiatric Research

Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Wagner FF, Benajiba L, Campbell AJ, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018;10(431). doi:10.1126/scitranslmed.aam8460.
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.
Lenihan JA, Saha O, Heimer-McGinn V, Cryan JF, Feng G, Young PW. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Mol Neurobiol. 2017;54(10):8090-8109. doi:10.1007/s12035-016-0261-0.
A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.
Feinberg K, Kolaj A, Wu C, et al. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017;216(11):3655-3675. doi:10.1083/jcb.201705085.
Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1.
Schecter RW, Maher EE, Welsh CA, Stevens B, Erisir A, Bear MF. Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1. J Neurosci. 2017;37(44):10541-10553. doi:10.1523/JNEUROSCI.2679-16.2017.
RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.
Ofengeim D, Mazzitelli S, Ito Y, et al. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114(41):E8788-E8797. doi:10.1073/pnas.1714175114.
Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease.
Kim J, Hughes EG, Shetty AS, et al. Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease. J Neurosci. 2017;37(37):9037-9053. doi:10.1523/JNEUROSCI.0811-17.2017.
Microglia emerge as central players in brain disease.
Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med. 2017;23(9):1018-1027. doi:10.1038/nm.4397.
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Tripathi P, Rodriguez-Muela N, Klim JR, et al. Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem Cell Reports. 2017;9(2):667-680. doi:10.1016/j.stemcr.2017.06.008.
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.
Song J, Bergen SE, Di Florio A, et al. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2017;22(8):1223. doi:10.1038/mp.2016.246.
Animal models for neuropsychiatric disorders: prospects for circuit intervention.
Kaiser T, Zhou Y, Feng G. Animal models for neuropsychiatric disorders: prospects for circuit intervention. Curr Opin Neurobiol. 2017;45:59-65. doi:10.1016/j.conb.2017.03.010.
InDrops and Drop-seq technologies for single-cell sequencing.
Klein AM, Macosko E. InDrops and Drop-seq technologies for single-cell sequencing. Lab Chip. 2017;17(15):2540-2541. doi:10.1039/c7lc90070h.
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.
Andrews PW, Ben-David U, Benvenisty N, et al. Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem Cell Reports. 2017;9(1):1-4. doi:10.1016/j.stemcr.2017.05.029.
Addendum: A viral strategy for targeting and manipulating interneurons across vertebrate species.
Dimidschstein J, Chen Q, Tremblay R, et al. Addendum: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2017;20(7):1033. doi:10.1038/nn0717-1033d.
Corrigendum: A viral strategy for targeting and manipulating interneurons across vertebrate species.
Dimidschstein J, Chen Q, Tremblay R, et al. Corrigendum: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2017;20(7):1033. doi:10.1038/nn0717-1033c.
Corrigendum: Opportunities and challenges in modeling human brain disorders in transgenic primates.
Jennings C, Landman R, Zhou Y, et al. Corrigendum: Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci. 2017;20(7):1033. doi:10.1038/nn0717-1033b.
Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource.
Purcell SM, Manoach DS, Demanuele C, et al. Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource. Nat Commun. 2017;8:15930. doi:10.1038/ncomms15930.
Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases.
Palomo V, Perez DI, Roca C, et al. Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. J Med Chem. 2017;60(12):4983-5001. doi:10.1021/acs.jmedchem.7b00395.
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.
Shi Q, Chowdhury S, Ma R, et al. Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017;9(392). doi:10.1126/scitranslmed.aaf6295.
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Merkle FT, Ghosh S, Kamitaki N, et al. Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature. 2017;545(7653):229-233. doi:10.1038/nature22312.
Cell diversity and network dynamics in photosensitive human brain organoids.
Quadrato G, Nguyen T, Macosko EZ, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545(7652):48-53. doi:10.1038/nature22047.
Genetic and activity-dependent mechanisms underlying interneuron diversity.
Wamsley B, Fishell G. Genetic and activity-dependent mechanisms underlying interneuron diversity. Nat Rev Neurosci. 2017;18(5):299-309. doi:10.1038/nrn.2017.30.
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.
Wang W, Li C, Chen Q, et al. Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism. J Clin Invest. 2017;127(5):1978-1990. doi:10.1172/JCI87997.
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.
Platt RJ, Zhou Y, Slaymaker IM, et al. Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. Cell Rep. 2017;19(2):335-350. doi:10.1016/j.celrep.2017.03.052.
Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia.
Wallace ML, Saunders A, Huang KWui, et al. Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia. Neuron. 2017;94(1):138-152.e5. doi:10.1016/j.neuron.2017.03.017.
The Path to New Therapies for Schizophrenia and Bipolar Illness.
Scolnick EM. The Path to New Therapies for Schizophrenia and Bipolar Illness. FASEB J. 2017;31(4):1254-1259. doi:10.1096/fj.201700028.
Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.
Schuetze KB, Stratton MS, Blakeslee WW, et al. Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts. J Pharmacol Exp Ther. 2017;361(1):140-150. doi:10.1124/jpet.116.237701.
A molecular census of arcuate hypothalamus and median eminence cell types.
Campbell JN, Macosko EZ, Fenselau H, et al. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017;20(3):484-496. doi:10.1038/nn.4495.
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.
Kim MJ, Biag J, Fass DM, et al. Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. Mol Psychiatry. 2017;22(3):417-429. doi:10.1038/mp.2016.98.
SHANK proteins: roles at the synapse and in autism spectrum disorder.
Monteiro P, Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder. Nat Rev Neurosci. 2017;18(3):147-157. doi:10.1038/nrn.2016.183.
Comparative Analysis Highlights Variable Genome Content of Wheat Rusts and Divergence of the Mating Loci.
Cuomo CA, Bakkeren G, Khalil HBadr, et al. Comparative Analysis Highlights Variable Genome Content of Wheat Rusts and Divergence of the Mating Loci. G3 (Bethesda). 2017;7(2):361-376. doi:10.1534/g3.116.032797.
Studying human disease using human neurons.
Ahfeldt T, Litterman NK, Rubin LL. Studying human disease using human neurons. Brain Res. 2017;1656:40-48. doi:10.1016/j.brainres.2016.03.051.
Editorial overview: Developmental neuroscience 2017.
Arlotta P, Vanderhaeghen P. Editorial overview: Developmental neuroscience 2017. Curr Opin Neurobiol. 2017;42:A1-A4. doi:10.1016/j.conb.2017.01.003.
Neurotoxic reactive astrocytes are induced by activated microglia.
Liddelow SA, Guttenplan KA, Clarke LE, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541(7638):481-487. doi:10.1038/nature21029.
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.
Marshall CR, Howrigan DP, Merico D, et al. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat Genet. 2017;49(1):27-35. doi:10.1038/ng.3725.
Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function.
Hong S, Wilton DK, Stevens B, Richardson DS. Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function. Methods Mol Biol. 2017;1538:155-167. doi:10.1007/978-1-4939-6688-2_12.
A scored human protein-protein interaction network to catalyze genomic interpretation.
Li T, Wernersson R, Hansen RB, et al. A scored human protein-protein interaction network to catalyze genomic interpretation. Nat Methods. 2017;14(1):61-64. doi:10.1038/nmeth.4083.
Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection.
Wells MF, Salick MR, Wiskow O, et al. Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection. Cell Stem Cell. 2016;19(6):703-708. doi:10.1016/j.stem.2016.11.011.
A viral strategy for targeting and manipulating interneurons across vertebrate species.
Dimidschstein J, Chen Q, Tremblay R, et al. A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci. 2016;19(12):1743-1749. doi:10.1038/nn.4430.
Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome.
Hamilton EP, Kapusta A, Huvos PE, et al. Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome. Elife. 2016;5. doi:10.7554/eLife.19090.
Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome.
Banerjee A, Rikhye RV, Breton-Provencher V, et al. Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome. Proc Natl Acad Sci U S A. 2016;113(46):E7287-E7296. doi:10.1073/pnas.1615330113.
Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.
Wang L, Brooks AN, Fan J, et al. Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia. Cancer Cell. 2016;30(5):750-763. doi:10.1016/j.ccell.2016.10.005.
Balancing selection shapes density-dependent foraging behaviour.
Greene JS, Brown M, Dobosiewicz M, et al. Balancing selection shapes density-dependent foraging behaviour. Nature. 2016;539(7628):254-258. doi:10.1038/nature19848.
Increasing the neurological-disease toolbox using iPSC-derived microglia.
Hammond TR, Stevens B. Increasing the neurological-disease toolbox using iPSC-derived microglia. Nat Med. 2016;22(11):1206-1207. doi:10.1038/nm.4226.
The promises and challenges of human brain organoids as models of neuropsychiatric disease.
Quadrato G, Brown J, Arlotta P. The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat Med. 2016;22(11):1220-1228. doi:10.1038/nm.4214.
Back to basics: luring industry back into neuroscience.
Hyman SE. Back to basics: luring industry back into neuroscience. Nat Neurosci. 2016;19(11):1383-1384. doi:10.1038/nn.4429.
Research Into Brain Disorders as an Example of Targeted Science.
Hyman SE, Landis SC, Leshner AI. Research Into Brain Disorders as an Example of Targeted Science. JAMA. 2016;316(16):1673-1674. doi:10.1001/jama.2016.12412.
A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity.
Andrade A, Hope J, Allen A, Yorgan V, Lipscombe D, Pan JQ. A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity. Sci Rep. 2016;6:34233. doi:10.1038/srep34233.
Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding.
Chen N, Sugihara H, Kim J, et al. Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding. Elife. 2016;5. doi:10.7554/eLife.18716.
Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?
Manoach DS, Pan JQ, Purcell SM, Stickgold R. Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?. Biol Psychiatry. 2016;80(8):599-608. doi:10.1016/j.biopsych.2015.10.003.
Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.
Coleman JJ, Komura T, Munro J, et al. Activity of caffeic acid phenethyl ester in Caenorhabditis elegans. Future Med Chem. 2016. doi:10.4155/fmc-2016-0085.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Wagner FF, Weïwer M, Steinbacher S, et al. Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg Med Chem. 2016;24(18):4008-4015. doi:10.1016/j.bmc.2016.06.040.
Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9.
Herring A, Messana A, Bara AM, Hazelbaker DZ, Eggan K, Barrett LE. Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Res. 2016;17(2):430-432. doi:10.1016/j.scr.2016.09.009.
Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9.
Bara AM, Messana A, Herring A, Hazelbaker DZ, Eggan K, Barrett LE. Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Res. 2016;17(2):441-443. doi:10.1016/j.scr.2016.09.008.
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.
Song J, Bergen SE, Di Florio A, et al. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2016;21(9):1290-7. doi:10.1038/mp.2015.165.
Opportunities and challenges in modeling human brain disorders in transgenic primates.
Jennings CG, Landman R, Zhou Y, et al. Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci. 2016;19(9):1123-30. doi:10.1038/nn.4362.
Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.
Loh KH, Stawski PS, Draycott AS, et al. Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Cell. 2016;166(5):1295-1307.e21. doi:10.1016/j.cell.2016.07.041.
Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics.
Shekhar K, Lapan SW, Whitney IE, et al. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016;166(5):1308-1323.e30. doi:10.1016/j.cell.2016.07.054.
Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells.
Santos DP, Kiskinis E, Eggan K, Merkle FT. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2016;38:5B.6.1-5B.6.60. doi:10.1002/cpsc.15.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Liang SH, Chen JMichael, Normandin MD, et al. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016;55(33):9601-5. doi:10.1002/anie.201603797.
Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons.
Zhao B, Zhu J, Dai D, et al. Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons. Neuropharmacology. 2016;107:396-410. doi:10.1016/j.neuropharm.2016.03.037.
Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression.
Schafer DP, Heller CT, Gunner G, et al. Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife. 2016;5. doi:10.7554/eLife.15224.
Microglia: Phagocytosing to Clear, Sculpt, and Eliminate.
Hong S, Stevens B. Microglia: Phagocytosing to Clear, Sculpt, and Eliminate. Dev Cell. 2016;38(2):126-8. doi:10.1016/j.devcel.2016.07.006.
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.
Wagner FF, Bishop JA, Gale JP, et al. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 2016;11(7):1952-63. doi:10.1021/acschembio.6b00306.
Unbiased Deep Sequencing of RNA Viruses from Clinical Samples.
Matranga CB, Gladden-Young A, Qu J, et al. Unbiased Deep Sequencing of RNA Viruses from Clinical Samples. J Vis Exp. 2016;(113). doi:10.3791/54117.
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.
Stein MB, Chen C-Y, Ursano RJ, et al. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry. 2016;73(7):695-704. doi:10.1001/jamapsychiatry.2016.0350.
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.
Han B, Pouget JG, Slowikowski K, et al. A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet. 2016;48(7):803-10. doi:10.1038/ng.3572.
A complement-microglial axis drives synapse loss during virus-induced memory impairment.
Vasek MJ, Garber C, Dorsey D, et al. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016;534(7608):538-43. doi:10.1038/nature18283.
Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System.
Rigamonti A, Repetti GG, Sun C, et al. Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System. Stem Cell Reports. 2016;6(6):993-1008. doi:10.1016/j.stemcr.2016.05.010.
Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures.
Lu Y, Zhong C, Wang L, et al. Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nat Commun. 2016;7:12019. doi:10.1038/ncomms12019.
Exome Sequencing of Familial Bipolar Disorder.
Goes FS, Pirooznia M, Parla JS, et al. Exome Sequencing of Familial Bipolar Disorder. JAMA Psychiatry. 2016;73(6):590-7. doi:10.1001/jamapsychiatry.2016.0251.
Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers.
Berglund K, Wen L, Dunbar RL, Feng G, Augustine GJ. Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers. J Neurosci. 2016;36(21):5709-23. doi:10.1523/JNEUROSCI.4366-15.2016.
Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies.
Ma Y, Li J, Wang G, et al. Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies. Sci Rep. 2016;6:25888. doi:10.1038/srep25888.
Adult axolotls can regenerate original neuronal diversity in response to brain injury.
Amamoto R, Huerta VGisselle L, Takahashi E, et al. Adult axolotls can regenerate original neuronal diversity in response to brain injury. Elife. 2016;5. doi:10.7554/eLife.13998.
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
Hong S, Beja-Glasser VF, Nfonoyim BM, et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016;352(6286):712-716. doi:10.1126/science.aad8373.
Use of the MS2 aptamer and coat protein for RNA localization in yeast: A response to "MS2 coat proteins bound to yeast mRNAs block 5' to 3' degradation and trap mRNA decay products: implications for the localization of mRNAs by MS2-MCP system".
Haimovich G, Zabezhinsky D, Haas B, et al. Use of the MS2 aptamer and coat protein for RNA localization in yeast: A response to "MS2 coat proteins bound to yeast mRNAs block 5' to 3' degradation and trap mRNA decay products: implications for the localization of mRNAs by MS2-MCP system". RNA. 2016;22(5):660-6. doi:10.1261/rna.055095.115.
Neurobiology of social behavior abnormalities in autism and Williams syndrome.
Barak B, Feng G. Neurobiology of social behavior abnormalities in autism and Williams syndrome. Nat Neurosci. 2016;19(6):647-55. doi:10.1038/nn.4276.
Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice.
Wells MF, Wimmer RD, L Schmitt I, Feng G, Halassa MM. Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice. Nature. 2016;532(7597):58-63. doi:10.1038/nature17427.
Modeling ALS with motor neurons derived from human induced pluripotent stem cells.
Sances S, Bruijn LI, Chandran S, et al. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016;19(4):542-53. doi:10.1038/nn.4273.
Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures.
Lu Y, Zhong C, Wang L, et al. Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nat Commun. 2016;7:10962. doi:10.1038/ncomms10962.
Stressed out? Healing Tips for Newly Reprogrammed Neurons.
Quadrato G, Zhang AC, Arlotta P. Stressed out? Healing Tips for Newly Reprogrammed Neurons. Cell Stem Cell. 2016;18(3):297-9. doi:10.1016/j.stem.2016.02.008.
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.
Mei Y, Monteiro P, Zhou Y, et al. Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature. 2016;530(7591):481-4. doi:10.1038/nature16971.
Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.
Ma L, Chen Z, Huang DWei, et al. Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts. Nat Commun. 2016;7:10740. doi:10.1038/ncomms10740.
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.
Wagner FF, Lundh M, Kaya T, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol. 2016;11(2):363-74. doi:10.1021/acschembio.5b00640.
Cellular neuroscience. Differences among astrocytes.
Stevens B, Muthukumar AK. Cellular neuroscience. Differences among astrocytes. Science. 2016;351(6275):813. doi:10.1126/science.aaf2849.
Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.
Zhang Q, Gao X, Li C, et al. Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016;36(7):2247-60. doi:10.1523/JNEUROSCI.2528-15.2016.
Schizophrenia risk from complex variation of complement component 4.
Sekar A, Bialas AR, de Rivera H, et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530(7589):177-83. doi:10.1038/nature16549.
CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors.
Loebrich S, Benoit MRobert, Konopka JAleksandra, Cottrell JRichard, Gibson J, Nedivi E. CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors. Curr Biol. 2016;26(3):296-308. doi:10.1016/j.cub.2015.11.071.
Seq-ing the cortex one neuron at a time.
Chen H-H, Arlotta P. Seq-ing the cortex one neuron at a time. Nat Neurosci. 2016;19(2):179-81. doi:10.1038/nn.4230.
New insights on the role of microglia in synaptic pruning in health and disease.
Hong S, Dissing-Olesen L, Stevens B. New insights on the role of microglia in synaptic pruning in health and disease. Curr Opin Neurobiol. 2016;36:128-34. doi:10.1016/j.conb.2015.12.004.
Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3.
Lu C, Chen Q, Zhou T, et al. Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3. Mol Psychiatry. 2016;21(2):159-68. doi:10.1038/mp.2015.173.
Diversity Matters: A Revised Guide to Myelination.
Tomassy GSrubek, Dershowitz LBowe, Arlotta P. Diversity Matters: A Revised Guide to Myelination. Trends Cell Biol. 2016;26(2):135-147. doi:10.1016/j.tcb.2015.09.002.
Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis.
Cottrell JR, Li B, Kyung JWon, et al. Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. J Biol Chem. 2016;291(4):1948-56. doi:10.1074/jbc.M115.705319.
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.
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