Metabolism Program

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease.

Marutani E, Miranda M, Durham TJ, et al. Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease. Nature neuroscience. 2025. doi:10.1038/s41593-025-02010-4Google Scholar PubMed DOI

Zhou Y, Ahsan FM, Emans SW, Soukas AA. The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity. Molecular cell. 2025. doi:10.1016/j.molcel.2025.08.035Google Scholar PubMed DOI

Deutsch AJ, Bell AS, Michalek DA, et al. Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score. Diabetes. 2025. doi:10.2337/db25-0772Google Scholar PubMed DOI

Meisel JD, Joshi PR, Spelbring AN, et al. Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency. Nature. 2025. doi:10.1038/s41586-025-09821-2Google Scholar PubMed DOI

Reiner AP, Raffield LM, Franceschini N, et al. Effect of Sickle Cell Trait and Genotype on the Association of Soluble uPAR with Kidney Function Measures in Black Americans. Clinical journal of the American Society of Nephrology : CJASN. 2021;16(2):287-289. doi:10.2215/CJN.12100720Google Scholar PubMed DOI

Sherva R, Gross A, Mukherjee S, et al. Genome-wide association study of rate of cognitive decline in Alzheimer’s disease patients identifies novel genes and pathways. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2020;16(8):1134-1145. doi:10.1002/alz.12106PubMed Central Google Scholar PubMed DOI

PMCID

PMC7924136

Bao XR, Ong SE, Goldberger O, et al. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Elife. 2016;5. doi:10.7554/eLife.10575Google Scholar PubMed DOI

Rees MG, Seashore-Ludlow B, Cheah JH, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nat Chem Biol. 2016;12(2):109-16. doi:10.1038/nchembio.1986Google Scholar PubMed DOI